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Genome assembly using high throughput data with short reads, arguably, remains an unresolvable task in repetitive genomes, since when the length of a repeat exceeds the read length, it becomes difficult to unambiguously connect the flanking…

Quantitative Methods · Quantitative Biology 2013-07-31 Viraj Deshpande , Eric DK Fung , Son Pham , Vineet Bafna

Motivation: Seed filtering is critical in DNA read mapping, a process where billions of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to identify genomic variants of the donor. Read mappers 1) quickly…

K-mer abundance analysis is widely used for many purposes in nucleotide sequence analysis, including data preprocessing for de novo assembly, repeat detection, and sequencing coverage estimation. We present the khmer software package for…

Genomics · Quantitative Biology 2014-08-07 Qingpeng Zhang , Jason Pell , Rosangela Canino-Koning , Adina Chuang Howe , C. Titus Brown

The prevailing deep learning-based methods of predicting cardiac segmentation involve reconstructed magnetic resonance (MR) images. The heavy dependency of segmentation approaches on image quality significantly limits the acceleration rate…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Yundi Zhang , Nil Stolt-Ansó , Jiazhen Pan , Wenqi Huang , Kerstin Hammernik , Daniel Rueckert

Motivation: Next generation methods of DNA sequencing produce relatively high rate of reading errors, which interfere with de novo genome assembly of newly sequenced organisms and particularly affect the quality of SNP detection important…

Genomics · Quantitative Biology 2019-07-31 Oleg Fokin , Anastasia Bakulina , Igor Seledtsov , Victor Solovyev

BERT is a widely used pre-trained model in natural language processing. However, since BERT is quadratic to the text length, the BERT model is difficult to be used directly on the long-text corpus. In some fields, the collected text data…

Computation and Language · Computer Science 2022-09-27 Yufeng Zhao , Haiying Che

The $k$-means algorithm (Lloyd's algorithm) is a widely used method for clustering unlabeled data. A key bottleneck of the $k$-means algorithm is that each iteration requires time linear in the number of data points, which can be expensive…

The continuous advancement of large language models (LLMs) has brought increasing attention to the critical issue of developing fair and reliable methods for evaluating their performance. Particularly, the emergence of cheating phenomena,…

Computation and Language · Computer Science 2025-02-26 Qingchen Yu , Zifan Zheng , Shichao Song , Zhiyu Li , Feiyu Xiong , Bo Tang , Ding Chen

Large Language Models (LLMs) are transforming information extraction from academic literature, offering new possibilities for knowledge management. This study presents an LLM-based system designed to extract detailed information about…

Information Retrieval · Computer Science 2025-05-29 Jiseung Yoo , Curran Mahowald , Meiyu Li , Wei Ai

By facilitating the generation of samples from arbitrary probability distributions, Markov Chain Monte Carlo (MCMC) is, arguably, \emph{the} tool for the evaluation of Bayesian inference problems that yield non-standard posterior…

Computation · Statistics 2021-05-27 Peter L Green , Robert E Moore , Ryan J Jackson , Jinglai Li , Simon Maskell

Remarkable success has been achieved in the last few years on some limited machine reading comprehension (MRC) tasks. However, it is still difficult to interpret the predictions of existing MRC models. In this paper, we focus on extracting…

Computation and Language · Computer Science 2019-09-25 Hai Wang , Dian Yu , Kai Sun , Jianshu Chen , Dong Yu , David McAllester , Dan Roth

A common problem in large-scale data analysis is to approximate a matrix using a combination of specifically sampled rows and columns, known as CUR decomposition. Unfortunately, in many real-world environments, the ability to sample…

Machine Learning · Statistics 2018-07-10 Urvashi Oswal , Swayambhoo Jain , Kevin S. Xu , Brian Eriksson

Model extraction attacks (MEAs) on large language models (LLMs) have received increasing attention in recent research. However, existing attack methods typically adapt the extraction strategies originally developed for deep neural networks…

Cryptography and Security · Computer Science 2025-05-20 Zi Liang , Qingqing Ye , Yanyun Wang , Sen Zhang , Yaxin Xiao , Ronghua Li , Jianliang Xu , Haibo Hu

RNA-sequencing (RNA-seq) has become an exemplar technology in modern biology and clinical applications over the past decade. It has gained immense popularity in the recent years driven by continuous efforts of the bioinformatics community…

Many efforts have been made to facilitate natural language processing tasks with pre-trained language models (LMs), and brought significant improvements to various applications. To fully leverage the nearly unlimited corpora and capture…

Computation and Language · Computer Science 2018-09-11 Liyuan Liu , Xiang Ren , Jingbo Shang , Jian Peng , Jiawei Han

Big data mining is well known to be an important task for data science, because it can provide useful observations and new knowledge hidden in given large datasets. Proximity-based data analysis is particularly utilized in many real-life…

Databases · Computer Science 2022-11-29 Daichi Amagata , Yusuke Arai , Sumio Fujita , Takahiro Hara

Metric and kernel learning are important in several machine learning applications. However, most existing metric learning algorithms are limited to learning metrics over low-dimensional data, while existing kernel learning algorithms are…

Machine Learning · Computer Science 2009-11-02 Prateek Jain , Brian Kulis , Jason V. Davis , Inderjit S. Dhillon

K-means is one of the most widely used algorithms for clustering in Data Mining applications, which attempts to minimize the sum of the square of the Euclidean distance of the points in the clusters from the respective means of the…

Machine Learning · Computer Science 2016-11-01 Sayantan Dasgupta

Machine Reading Comprehension (MRC) poses a significant challenge in the field of Natural Language Processing (NLP). While mainstream MRC methods predominantly leverage extractive strategies using encoder-only models such as BERT,…

Computation and Language · Computer Science 2024-10-17 Lin Ai , Zheng Hui , Zizhou Liu , Julia Hirschberg

In this paper we present new algorithms for training reduced-size nonlinear representations in the Kernel Dictionary Learning (KDL) problem. Standard KDL has the drawback of a large size of the kernel matrix when the data set is large.…

Signal Processing · Electrical Eng. & Systems 2023-07-19 Denis C. Ilie-Ablachim , Bogdan Dumitrescu
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