Related papers: Optimizing Radiotherapy Plans for Cancer Treatment…
Radiotherapy dosimetry plays a crucial role in optimizing treatment plans for cancer patients. In this study, we investigate the performance of a dozen standard state-of-the-art open-source optimizers for radiotherapy dosimetry. Our…
Radiation treatment planning involves optimization over a large number of voxels, many of which carry limited information about the clinical problem. We propose an approach to reduce the large optimization problem by only using a…
This work is motivated by multimodality breast cancer imaging data, which is quite challenging in that the signals of discrete tumor-associated microvesicles (TMVs) are randomly distributed with heterogeneous patterns. This imposes a…
Stereotactic body radiotherapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam's-eye-view) known as "apertures". Mathematical methods can be…
We summarize recent results and ongoing activities in mathematical algorithms and computer science methods related to proton computed tomography (pCT) and intensity-modulated particle therapy (IMPT) treatment planning. Proton therapy…
To promote precision medicine, individualized treatment regimes (ITRs) are crucial for optimizing the expected clinical outcome based on patient-specific characteristics. However, existing ITR research has primarily focused on scenarios…
Combinatorial optimization is of general interest for both theoretical study and real-world applications. Fast-developing quantum algorithms provide a different perspective on solving combinatorial optimization problems. In this paper, we…
Intensity modulated proton therapy (IMPT) provides highly conformal dose distributions through the application of multiple, angularly spaced fields, each applying an ad-hoc pattern of spatially varying particle fluences. In particular,…
The complexity of human cancer often results in significant heterogeneity in response to treatment. Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity. Individualized treatment rules (ITRs)…
Radiation therapy is the primary method used to treat cancer in the clinic. Its goal is to deliver a precise dose to the planning target volume (PTV) while protecting the surrounding organs at risk (OARs). However, the traditional workflow…
Skin cancer is one of the most prevalent and preventable types of cancer, yet its early detection remains a challenge, particularly in resource-limited settings where access to specialized healthcare is scarce. This study proposes an…
Purpose: There is growing interest in the use of modern 3D printing technology to implement intensity-modulated radiation therapy (IMRT) on the preclinical scale which is analogous to clinical IMRT. However, current 3D-printed IMRT methods…
Tumors can manifest in various forms and in different areas of the human body. Brain tumors are specifically hard to diagnose and treat because of the complexity of the organ in which they develop. Detecting them in time can lower the…
Tensor networks provide compact and scalable representations of high-dimensional data, enabling efficient computation in fields such as quantum physics, numerical partial differential equations (PDEs), and machine learning. This paper…
Beam orientation optimization (BOO) is a key component in the process of IMRT treatment planning. It determines to what degree one can achieve a good treatment plan quality in the subsequent plan optimization process. In this paper, we have…
Particle physics simulations are the cornerstone of nuclear engineering applications. Among them radiotherapy (RT) is crucial for society, with 50% of cancer patients receiving radiation treatments. For the most precise targeting of tumors,…
With the continued evolution of modern radiation therapy towards high precision delivery of high therapeutic doses to the tumour while optimally sparing surrounding healthy tissue, imaging becomes a crucial component to identify the…
Cancer is one of the most common diseases worldwide, posing a serious threat to human health and leading to the deaths of a large number of people. It was observed during the drug administration in chemotherapy that immune cells, cancer…
Magnetic Resonance Imaging (MRI) is the most commonly used non-intrusive technique for medical image acquisition. Brain tumor segmentation is the process of algorithmically identifying tumors in brain MRI scans. While many approaches have…
Radiologists often mix medical image reading strategies, including inspection of individual modalities and local image regions, using information at different locations from different images independently as well as concurrently. In this…