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It is generally acknowledged that claims from observational studies often fail to replicate. An exploratory study was undertaken to assess the reliability of base studies used in meta-analysis of short-term air quality-myocardial infarction…

Applications · Statistics 2019-04-04 S. Stanley Young , Warren B. Kindzierski

Claims from observational studies often fail to replicate. A study was undertaken to assess the reliability of cohort studies used in a highly cited meta-analysis of the association between ambient nitrogen dioxide, NO2, and fine…

Applications · Statistics 2020-10-22 S. Stanley Young , Kai-Chieh Cheng , Jin Hua Chen , Shu-Chuan Chen , Warren B. Kindzierski

Odds ratios or p_values from individual observational studies can be combined to examine a common cause_effect research question in meta_analysis. However, reliability of individual studies used in meta_analysis should not be taken for…

Applications · Statistics 2023-06-06 Warren B. Kindzierski , S. Stanley Young , John D. Dunn

Summary Background Claims made in science papers are coming under increased scrutiny with many claims failing to replicate. Meta-analysis studies that use unreliable observational studies should be in question. We examine the reliability of…

Applications · Statistics 2019-02-05 S. Stanley Young , Mithun Kumar Acharjee , Kumer Das

The current regulatory paradigm is that PM2.5, over time causes lung cancer. This claim is based on cohort studies and meta-analysis that use cohort studies as their base studies. There is a need to evaluate the reliability of this causal…

Applications · Statistics 2020-11-05 S. Stanley Young , Warren Kindzierski

The US EPA and the WHO claim that PM2.5 is causal of all-cause deaths. Both support and fund research on air quality and health effects. WHO funded a massive systematic review and meta-analyses of air quality and health-effect papers. 1,632…

Applications · Statistics 2020-11-03 S. Stanley Young , Warren Kindzierski

Despite considerable number of studies on risk factors for asthma onset, very little is known about their relative importance. To have a full picture of these factors, both categories, personal and environmental data, have to be taken into…

Computers and Society · Computer Science 2016-01-21 Mengfan Tang , Pranav Agrawal , Ramesh Jain

Few studies have linked specific sources of ambient particulate matter smaller than 2.5 $\mu$m (PM2.5) and asthma. In this study, we estimated the contributions of specific sources to PM2.5 and examined their association with daily asthma…

Multi-dimensional meta-analysis (MDMA) is an innovative technique for investigating complex scientific problems influenced by "external" factors, such as social, medical, economic, political or climatic trends. MDMA extends traditional…

General Mathematics · Mathematics 2007-05-23 J. I. Brand , M. S. Hallbeck , S. M. Ryan

Background: Risk ratios or p-values from multiple, independent studies, observational or randomized, can be computationally combined to provide an overall assessment of a research question in meta-analysis. However, an irreproducibility…

Applications · Statistics 2021-11-11 S. Stanley Young , Warren Kindzierski

According to the Lancet report on the global burden of disease published in October 2020, air pollution is among the five highest risk factors for global health, reducing life expectancy on average by 20 months. This paper describes a…

Applications · Statistics 2023-01-18 D K Arvind , S Maiya

Many studies have sought to determine if there is an association between air quality and acute deaths. Many consider it plausible that current levels of air quality cause acute deaths. However, several factors call causation and even…

Applications · Statistics 2015-05-15 Kenneth K. Lopiano , Richard L. Smith , S. Stanley Young

Studies have shown that exposure to air pollution, even at low levels, significantly increases mortality. As regulatory actions are becoming prohibitively expensive, robust evidence to guide the development of targeted interventions to…

Applications · Statistics 2018-02-20 Kwonsang Lee , Dylan S. Small , Francesca Dominici

Laboratory experiments have shown that cardiovascular diseases are positively correlated to the concentration of ambient air pollutants, such as SO2, NO2, PM10, etc. It has also been repeatedly reported in many countries that increased…

Applications · Statistics 2013-08-08 Menghui Li , Dasheng Luo , Chenghua Cao , Xiaochuan Pan , Qixin Wang

Asthma is a chronic disease of the airways of the lungs. It results in inflammation and narrowing of the respiratory passages, which prevents air flow into the airways and leads to frequent bouts of shortness of breath with wheezing…

Signal Processing · Electrical Eng. & Systems 2020-09-28 Rawabi A. Aroud , Anas H. Blasi , Mohammed A. Alsuwaiket

Respiratory ailments are increasing globally at an alarming rate and are currently one of the leading factors of death and infirmity worldwide. Among respiratory diseases, those linked to poor air quality and pollutants are increasing at a…

Quantitative Methods · Quantitative Biology 2025-12-03 Shelby Lacouture , Mitchell Kelley , Noah Plues , Laszlo Hunyadi , Emily Sundman , Annette Sobel , Robert V. Duncan

Estimating the health effects of multiple air pollutants is a crucial problem in public health, but one that is difficult due to unmeasured confounding bias. Motivated by this issue, we develop a framework for partial identification of…

Methodology · Statistics 2025-06-23 Suyeon Kang , Alexander Franks , Michelle Audirac , Danielle Braun , Joseph Antonelli

The Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address whether exposure to levels…

Methodology · Statistics 2020-01-09 Georgia Papadogeorgou , Francesca Dominici

Background: Many researchers have studied the relationship between diet and health. There are papers showing an association between the consumption of sugar-sweetened beverages and Type 2 diabetes. Many meta-analyses use individual studies…

Applications · Statistics 2017-10-09 Karl E. Peace , JingJing Yin , Haresh Rochani , Sarbesh Pandeya , S. Stanley Young

Ambient fine particulate matter less than 2.5 $\mu$m in aerodynamic diameter (PM$_{2.5}$) has been linked to various adverse health outcomes and has, therefore, gained interest in public health. However, the sparsity of air quality monitors…

Applications · Statistics 2018-02-12 Nancy Murray , Howard H. Chang , Heather Holmes , Yang Liu
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