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Environmental stochasticity is known to be a destabilizing factor, increasing abundance fluctuations and extinction rates of populations. However, the stability of a community may benefit from the differential response of species to…

Populations and Evolution · Quantitative Biology 2016-02-10 Matan Danino , Nadav M. Shnerb , Sandro Azaele , William E. Kunin , David A. Kessler

Population genetic studies have found evidence for dramatic population growth in recent human history. It is unclear how this recent population growth, combined with the effects of negative natural selection, has affected patterns of…

Populations and Evolution · Quantitative Biology 2014-02-11 Kirk E. Lohmueller

In the first paper of this series, we included the effects of population genetics in the agent-based Monte Carlo code HERITAGE under the hypothesis of neutral phenotypic effects. It implied that mutations (genetic changes) had only neutral…

Popular Physics · Physics 2025-02-12 Frédéric Marin , Camille Beluffi-Marin , Frédéric Fischer

The inheritance of characteristics induced by the environment has often been opposed to the theory of evolution by natural selection. Yet, while evolution by natural selection requires new heritable traits to be produced and transmitted, it…

Populations and Evolution · Quantitative Biology 2015-06-18 Olivier Rivoire , Stanislas Leibler

Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either…

Populations and Evolution · Quantitative Biology 2015-09-29 Áki J. Láruson , Floyd A. Reed

When predicting the fate and consequences of recurring deleterious mutations in self-fertilising populations most models developed make the assumption that populations have discrete non-overlapping generations. This makes them biologically…

Populations and Evolution · Quantitative Biology 2016-04-22 Diala Abu Awad , Viet-Chi Tran , Sylvain Billiard

Cell-to-cell variability is inherent to numerous biological processes, including cell migration. Quantifying and characterizing the variability of migrating cells is challenging, as it requires monitoring many cells for long time windows…

Biological Physics · Physics 2021-05-06 David B. Brückner , Alexandra Fink , Joachim O. Rädler , Chase P. Broedersz

Standard neutral population genetics theory with a strictly fixed population size has important limitations. An alternative model that allows independently fluctuating population sizes and reproduces the standard neutral evolution is…

Populations and Evolution · Quantitative Biology 2017-03-08 Thiparat Chotibut , David R. Nelson

Phenotypically structured equations arise in population biology to describe the interaction of species with their environment that brings the nutrients. This interaction usually leads to selection of the fittest individuals. Models used in…

Analysis of PDEs · Mathematics 2015-06-18 Alexander Lorz , Benoit Perthame

The dynamics of two competing species in a finite size community is one of the most studied problems in population genetics and community ecology. Stochastic fluctuations lead, inevitably, to the extinction of one of the species, but the…

Populations and Evolution · Quantitative Biology 2016-11-30 Matan Danino , David A. Kessler , Nadav M. Shnerb

When can complex ecological interactions drive an entire ecosystem into a persistent non-equilibrium state, where species abundances keep fluctuating without going to extinction? We show that high-diversity spatially-extended systems, in…

Populations and Evolution · Quantitative Biology 2019-08-27 Felix Roy , Matthieu Barbier , Giulio Biroli , Guy Bunin

The dynamics of populations is rich, taking into account that both, the individual's actions and the population's fitness are coupled. The way in which an individual chooses a strategy depends off course on the interaction with other…

Biological Physics · Physics 2007-07-20 Juan G. Diaz Ochoa

In the present article, we investigate the effects of dormancy on an abstract population genetic level. We first provide a short review of seed bank models in population genetics, and the role of dormancy for the interplay of evolutionary…

Probability · Mathematics 2020-12-03 Jochen Blath , Noemi Kurt

We study a family of selection-mutation models of a sexual population structured by a phenotypical trait. The main feature of these models is the asymmetric trait heredity or fecundity between the parents : we assume that each individual…

Analysis of PDEs · Mathematics 2022-04-11 Benoît Perthame , Martin Strugarek , Cécile Taing

Organisms that grow and survive in uncertain environments may need to change their physiological state as the environment changes. When the environment is uncertain, one strategy known as bet-hedging is to make these changes randomly and…

Cell Behavior · Quantitative Biology 2023-04-28 David Lacoste , Olivier Rivoire , David S. Tourigny

The goal of this article is to contribute towards the conceptual and quantitative understanding of the evolutionary benefits for (microbial) populations to maintain a seed bank (consisting of dormant individuals) when facing fluctuating…

Probability · Mathematics 2024-07-02 Jochen Blath , Felix Hermann , Martin Slowik

We present an algorithm for the stochastic simulation of gene expression and heterogeneous population dynamics. The algorithm combines an exact method to simulate molecular-level fluctuations in single cells and a constant-number Monte…

Computational Physics · Physics 2016-08-24 Daniel A. Charlebois , Jukka Intosalmi , Dawn Fraser , Mads Kaern

Game theoretic tools are utilized to analyze a one-locus continuous selection model of sex-specific meiotic drive by considering nonequivalence of the viabilities of reciprocal heterozygotes that might be noticed at an imprinted locus. The…

Populations and Evolution · Quantitative Biology 2015-12-07 Bijan Sarkar

Due to inherent noise in intracellular networks cellular decisions can be random, so genetically identical cells can display different phenotypic behavior even in identical environments. Most previous work in understanding the…

Molecular Networks · Quantitative Biology 2015-06-15 Michael Assaf , Elijah Roberts , Zaida Luthey-Schulten , Nigel Goldenfeld

Cellular behavior is governed by gene regulatory processes that are intrinsically dynamic and nonlinear, and are subject to non-negligible amounts of random fluctuations. Such conditions are ubiquitous in physical systems, where they have…

Molecular Networks · Quantitative Biology 2011-09-21 Jordi Garcia-Ojalvo