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Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any…

Methodology · Statistics 2010-12-21 Xu Han , Weijie Gu , Jianqing Fan

Instrumental variable (IV) methods are central to causal inference from observational data, particularly when a randomized experiment is not feasible. However, of the three conventional core IV identification conditions, only one, IV…

Methodology · Statistics 2025-09-23 Zhonghua Liu , Baoluo Sun , Ting Ye , David Richardson , Eric Tchetgen Tchetgen

Counterfactual explanations can be obtained by identifying the smallest change made to a feature vector to qualitatively influence a prediction; for example, from 'loan rejected' to 'awarded' or from 'high risk of cardiovascular disease' to…

Machine Learning · Computer Science 2020-05-05 Martin Pawelczyk , Johannes Haug , Klaus Broelemann , Gjergji Kasneci

Historically, applications of RFT in fMRI have relied on assumptions of smoothness, stationarity and Gaussianity. The first two assumptions have been addressed in Part 1 of this article series. Here we address the severe non-Gaussianity of…

Applications · Statistics 2023-12-19 Samuel Davenport , Armin Schwartzman , Thomas E. Nichols , Fabian J. E. Telschow

Standard inference about a scalar parameter estimated via GMM amounts to applying a t-test to a particular set of observations. If the number of observations is not very large, then moderately heavy tails can lead to poor behavior of the…

Econometrics · Economics 2020-07-15 Ulrich K. Mueller

Multiple testing plagues many important questions in finance such as fund and factor selection. We propose a new way to calibrate both Type I and Type II errors. Next, using a double-bootstrap method, we establish a t-statistic hurdle that…

Methodology · Statistics 2020-06-09 Campbell R. Harvey , Yan Liu

The most popular multiple testing procedures are stepwise procedures based on $P$-values for individual test statistics. Included among these are the false discovery rate (FDR) controlling procedures of Benjamini--Hochberg [J. Roy. Statist.…

Statistics Theory · Mathematics 2009-06-18 Arthur Cohen , Harold B. Sackrowitz , Minya Xu

Recent work on fact-checking addresses a realistic setting where models incorporate evidence retrieved from the web to decide the veracity of claims. A bottleneck in this pipeline is in retrieving relevant evidence: traditional methods may…

Computation and Language · Computer Science 2024-10-08 Aniruddh Sriram , Fangyuan Xu , Eunsol Choi , Greg Durrett

Consider a linear regression model with regression parameter beta=(beta_1,..., beta_p) and independent normal errors. Suppose the parameter of interest is theta = a^T beta, where a is specified. Define the s-dimensional parameter vector tau…

Statistics Theory · Mathematics 2017-10-18 Paul Kabaila , Davide Farchione

Multicollinearity is relevant to many different fields where linear regression models are applied, and its existence may affect the analysis of ordinary least squares (OLS) estimators from both the numerical and statistical points of views.…

Methodology · Statistics 2020-05-06 Román Salmerón , Catalina García , José García

Consider a linear regression model with n-dimensional response vector, regression parameter \beta = (\beta_1, ..., \beta_p) and independent and identically N(0, \sigma^2) distributed errors. Suppose that the parameter of interest is \theta…

Methodology · Statistics 2017-10-18 Paul Kabaila , Khageswor Giri

In observational studies, treatments are typically not randomized and therefore estimated treatment effects may be subject to confounding bias. The instrumental variable (IV) design plays the role of a quasi-experimental handle since the IV…

Methodology · Statistics 2016-08-30 Lan Liu , Wang Miao , Baoluo Sun , James Robins , Eric Tchetgen Tchetgen

Corrected confidence intervals are developed for the mean of the second component of a bivariate normal process when the first component is being monitored sequentially. This is accomplished by constructing a first approximation to a…

Statistics Theory · Mathematics 2007-06-13 R. C. Weng , D. S. Coad

In applications such as clinical safety analysis, the data of the experiments usually consists of frequency counts. In the analysis of such data, researchers often face the problem of multiple testing based on discrete test statistics,…

Methodology · Statistics 2019-08-15 Yalin Zhu , Wenge Guo

Extant "fast" algorithms for Monte Carlo confidence sets are limited to univariate shift parameters for the one-sample and two-sample problems using the sample mean as the test statistic; moreover, some do not converge reliably and most do…

Computation · Statistics 2025-02-27 Amanda K. Glazer , Philip B. Stark

Foundation model reliability assessment typically requires thousands of evaluation examples, making it computationally expensive and time-consuming for real-world deployment. We introduce microprobe, a novel approach that achieves…

Artificial Intelligence · Computer Science 2025-12-25 Aayam Bansal , Ishaan Gangwani

For a bucket test with a single criterion for success and a fixed number of samples or testing period, requiring a $p$-value less than a specified value of $\alpha$ for the success criterion produces statistical confidence at level $1 -…

Methodology · Statistics 2024-08-05 Eric Bax , Arundhyoti Sarkar , Alex Shtoff

Public data repositories have enabled researchers to compare results across multiple genomic studies in order to replicate findings. A common approach is to first rank genes according to an hypothesis of interest within each study. Then,…

Applications · Statistics 2012-06-29 Loki Natarajan , Minya Pu , Karen Messer

Controlling the false discovery rate (FDR) in high-dimensional variable selection requires balancing rigorous error control with statistical power. Existing methods with provable guarantees are often overly conservative, creating a…

Methodology · Statistics 2026-02-06 Arnau Vilella , Jasin Machkour , Michael Muma , Daniel P. Palomar

We show that confidence intervals in a variance component model, with asymptotically correct uniform coverage probability, can be obtained by inverting certain test-statistics based on the score for the restricted likelihood. The results…

Methodology · Statistics 2024-11-05 Yiqiao Zhang , Karl Oskar Ekvall , Aaron J. Molstad
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