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This work presents a novel approach for selecting the optimal ensemble-based classification method and features with a primarly focus on achieving generalization, based on the state-of-the-art, to provide diagnostic support for Sickle Cell…

Machine Learning · Computer Science 2026-01-21 Nataša Petrović , Gabriel Moyà-Alcover , Antoni Jaume-i-Capó , Jose Maria Buades Rubio

We introduce a machine learning-based method for fully automated diagnosis of sickle cell disease of poor-quality unstained images of a mobile microscope. Our method is capable of distinguishing between diseased, trait (carrier), and normal…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Sahar A. Nasser , Debjani Paul , Suyash P. Awate

Red blood cell (RBC) deformation is the consequence of several diseases, including sickle cell anemia, which causes recurring episodes of pain and severe pronounced anemia. Monitoring patients with these diseases involves the observation of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Wilkie Delgado-Font , Miriela Escobedo-Nicot , Manuel González-Hidalgo , Silena Herold-Garcia , Antoni Jaume-i-Capó , Arnau Mir

Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer…

Image and Video Processing · Electrical Eng. & Systems 2019-12-17 Wei Qiu , Jiaming Guo , Xiang Li , Mengjia Xu , Mo Zhang , Ning Guo , Quanzheng Li

Sickle cell anemia, which is characterized by abnormal erythrocyte morphology, can be detected using microscopic images. Computational techniques in medicine enhance the diagnosis and treatment efficiency. However, many computational…

Computer Vision and Pattern Recognition · Computer Science 2024-12-25 Victor Júnio Alcântara Cardoso , Rodrigo Moreira , João Fernando Mari , Larissa Ferreira Rodrigues Moreira

Despite fluorescent cell-labelling being widely employed in biomedical studies, some of its drawbacks are inevitable, with unsuitable fluorescent probes or probes inducing a functional change being the main limitations. Consequently, the…

Quantitative Methods · Quantitative Biology 2020-03-03 Yan Ge , Philipp Rosendahl , Claudio Durán , Nicole Töpfner , Sara Ciucci , Jochen Guck , Carlo Vittorio Cannistraci

Pathology deals with the practice of discovering the reasons for disease by analyzing the body samples. The most used way in this field, is to use histology which is basically studying and viewing microscopic structures of cell and tissues.…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Virender Ranga , Shivam Gupta , Priyansh Agrawal , Jyoti Meena

Machine learning (ML) and deep learning (DL) models have been employed to significantly improve analyses of medical imagery, with these approaches used to enhance the accuracy of prediction and classification. Model predictions and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Rabia Asghar , Sanjay Kumar , Paul Hynds , Arslan Shaukat

Identification of abnormalities in red blood cells (RBC) is key to diagnosing a range of medical conditions from anaemia to liver disease. Currently this is done manually, a time-consuming and subjective process. This paper presents an…

Computer Vision and Pattern Recognition · Computer Science 2021-06-02 Annika Wong , Nantheera Anantrasirichai , Thanarat H. Chalidabhongse , Duangdao Palasuwan , Attakorn Palasuwan , David Bull

The shape of erythrocytes or red blood cells is altered in several pathological conditions. Therefore, identifying and quantifying different erythrocyte shapes can help diagnose various diseases and assist in designing a treatment strategy.…

Quantitative Methods · Quantitative Biology 2023-05-04 Manish Bhatia , Balram Meena , Vipin Kumar Rathi , Prayag Tiwari , Amit Kumar Jaiswal , Shagaf M Ansari , Ajay Kumar , Pekka Marttinen

This paper proposes a novel automatic classification framework for the recognition of five types of white blood cells. Segmenting complete white blood cells from blood smears images and extracting advantageous features from them remain…

Computer Vision and Pattern Recognition · Computer Science 2020-09-07 Na Dong , Meng-die Zhai , Jian-fang Chang , Chun-ho Wu

The diagnosis of blood-based diseases often involves identifying and characterizing patient blood samples. Automated methods to detect and classify blood cell subtypes have important medical applications. Automated medical image processing…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Sai Sukruth Bezugam

Reliable cell segmentation and classification from biomedical images is a crucial step for both scientific research and clinical practice. A major challenge for more robust segmentation and classification methods is the large variations in…

Cell Behavior · Quantitative Biology 2017-10-31 Mo Zhang , Xiang Li , Mengjia Xu , Quanzheng Li

Accurate classification of white blood cells in peripheral blood is essential for diagnosing hematological diseases. Due to constantly evolving clinical settings, data sources, and disease classifications, it is necessary to update machine…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Ario Sadafi , Raheleh Salehi , Armin Gruber , Sayedali Shetab Boushehri , Pascal Giehr , Nassir Navab , Carsten Marr

Label-free cell classification is advantageous for supplying pristine cells for further use or examination, yet existing techniques frequently fall short in terms of specificity and speed. In this study, we address these limitations through…

Image and Video Processing · Electrical Eng. & Systems 2025-02-25 Khayrul Islam , Ratul Paul , Shen Wang , Yuwen Zhao , Partho Adhikary , Qiying Li , Xiaochen Qin , Yaling Liu

Predicting if red blood cells (RBC) are infected with the malaria parasite is an important problem in Pathology. Recently, supervised machine learning approaches have been used for this problem, and they have had reasonable success. In…

Computer Vision and Pattern Recognition · Computer Science 2020-10-05 Anik Khan , Kishor Datta Gupta , Deepak Venugopal , Nirman Kumar

Label-free approaches are attractive in cytological imaging due to their flexibility and cost efficiency. They are supported by machine learning methods, which, despite the lack of labeling and the associated lower contrast, can classify…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Stefan Röhrl , Johannes Groll , Manuel Lengl , Simon Schumann , Christian Klenk , Dominik Heim , Martin Knopp , Oliver Hayden , Klaus Diepold

Red blood cells are highly deformable and present in various shapes. In blood cell disorders, only a subset of all cells is morphologically altered and relevant for the diagnosis. However, manually labeling of all cells is laborious,…

Computer Vision and Pattern Recognition · Computer Science 2020-07-24 Ario Sadafi , Asya Makhro , Anna Bogdanova , Nassir Navab , Tingying Peng , Shadi Albarqouni , Carsten Marr

Blood cell classification and counting are vital for the diagnosis of various blood-related diseases, such as anemia, leukemia, and thrombocytopenia. The manual process of blood cell classification and counting is time-consuming, prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Sohag Kumar Mondal , Md. Simul Hasan Talukder , Mohammad Aljaidi , Rejwan Bin Sulaiman , Md Mohiuddin Sarker Tushar , Amjad A Alsuwaylimi

Sickle cell disease (SCD) is a major public health priority throughout much of the world, affecting millions of people. In many regions, particularly those in resource-limited settings, SCD is not consistently diagnosed. In Africa, where…

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