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Reaction networks can display a wide array of dynamics. However, it is possible for different reaction networks to display the same dynamics. This phenomenon is called dynamical equivalence and makes network identification a hard problem to…

Dynamical Systems · Mathematics 2022-05-03 Abhishek Deshpande

We prove that if a given reaction network $\mathcal{N}$ has a weakly reversible deficiency zero realization for all choice of rate constants, then there exists a $\textit{unique}$ weakly reversible deficiency zero network $\mathcal{N}'$…

Molecular Networks · Quantitative Biology 2025-02-26 Neal Buxton , Gheorghe Craciun , Abhishek Deshpande , Casian Pantea

Systems of differential equations with polynomial right-hand sides are very common in applications. On the other hand, their mathematical analysis is very challenging in general, due to the possibility of complex dynamics: multiple basins…

Dynamical Systems · Mathematics 2022-05-31 Gheorghe Craciun , Jiaxin Jin , Polly Y. Yu

Given a dynamical system with polynomial right-hand side, can it be generated by a reaction network that possesses certain properties? This question is important because some network properties may guarantee specific dynamical properties,…

Dynamical Systems · Mathematics 2023-03-17 Gheorghe Craciun , Abhishek Deshpande , Jiaxin Jin

We show that weakly reversible mass-action systems can have a continuum of positive steady states, coming from the zeroes of a multivariate polynomial. Moreover, the same is true of systems whose underlying reaction network is reversible…

Molecular Networks · Quantitative Biology 2022-09-14 Balázs Boros , Gheorghe Craciun , Polly Y. Yu

Mass-action kinetics is frequently used in systems biology to model the behaviour of interacting chemical species. Many important dynamical properties are known to hold for such systems if they are weakly reversible and have a low…

Dynamical Systems · Mathematics 2014-07-15 Matthew D. Johnston , David Siegel , Gábor Szederkényi

Very often, models in biology, chemistry, physics, and engineering are systems of polynomial or power-law ordinary differential equations, arising from a reaction network. Such dynamical systems can be generated by many different reaction…

Dynamical Systems · Mathematics 2020-01-01 Gheorghe Craciun , Jiaxin Jin , Polly Y. Yu

The well-known Deficiency One Theorem gives structural conditions on a chemical reaction network under which, for any set of parameter values, the steady states of the corresponding mass action system may be easily characterized. It is also…

Optimization and Control · Mathematics 2016-03-02 Matthew D. Johnston

A natural condition on the structure of the underlying chemical reaction network, namely weak reversibility, is shown to guarantee the existence of an equilibrium (steady state) in each positive stoichiometric compatibility class for the…

Quantitative Methods · Quantitative Biology 2011-11-14 Jian Deng , Christopher Jones , Martin Feinberg , Adrian Nachman

Systems of differential equations with polynomial right-hand sides are very common in applications. In particular, when restricted to the positive orthant, they appear naturally (according to the law of mass-action kinetics) in ecology,…

Dynamical Systems · Mathematics 2023-03-06 Gheorghe Craciun , Abhishek Deshpande , Jiaxin Jin

In the study of reaction networks and the polynomial dynamical systems that they generate, special classes of networks with important properties have been identified. These include reversible, weakly reversible}, and, more recently,…

Dynamical Systems · Mathematics 2020-07-30 David F. Anderson , James D. Brunner , Gheorghe Craciun , Matthew D. Johnston

An algorithm is given in this paper for the computation of dynamically equivalent weakly reversible realizations with the maximal number of reactions, for chemical reaction networks (CRNs) with mass action kinetics. The original problem…

Dynamical Systems · Mathematics 2011-07-05 Gabor Szederkenyi , Katalin M. Hangos , Zsolt Tuza

The induced kinetic differential equation of a reaction network endowed with mass action type kinetics is a system of polynomial differential equations. The problem studied here is: Given a polynomial differential equation, is it possible…

Dynamical Systems · Mathematics 2019-09-10 G. Craciun , M. D. Johnston , G. Szederkényi , E. Tonello , J. Tóth , P. Y. Yu

We establish a weak-strong uniqueness principle for solutions to entropy-dissipating reaction-diffusion equations: As long as a strong solution to the reaction-diffusion equation exists, any weak solution and even any renormalized solution…

Analysis of PDEs · Mathematics 2017-03-03 Julian Fischer

This paper is concerned with the dynamical properties of deterministically modeled chemical reaction systems with mass-action kinetics. Such models are ubiquitously found in chemistry, population biology, and the burgeoning field of systems…

Dynamical Systems · Mathematics 2011-06-20 David F. Anderson

It has been known for nearly a decade that deterministically modeled reaction networks that are weakly reversible and consist of a single linkage class have trajectories that are bounded from both above and below by positive constants (so…

Probability · Mathematics 2020-01-17 David F. Anderson , Daniele Cappelletti , Jinsu Kim

This paper studies the relations among system parameters, uniqueness, and stability of equilibria, for kinetic systems given in the form of polynomial ODEs. Such models are commonly used to describe the dynamics of nonnegative systems, with…

Molecular Networks · Quantitative Biology 2016-11-14 Antonio A. Alonso , Gabor Szederkenyi

Under suitable assumptions, the dynamic behaviour of a chemical reaction network is governed by an autonomous set of polynomial ordinary differential equations over continuous variables representing the concentrations of the reactant…

Dynamical Systems · Mathematics 2014-07-15 Matthew D. Johnston , David Siegel

We establish weak-strong uniqueness and stability properties of renormalised solutions to a class of energy-reaction-diffusion systems. The systems considered are motivated by thermodynamically consistent models, and their formal entropy…

Analysis of PDEs · Mathematics 2022-05-03 Katharina Hopf

Reversibility, weak reversibility and deficiency, detailed and complex balancing are generally not "encoded" in the kinetic differential equations but they are realization properties that may imply local or even global asymptotic stability…

Molecular Networks · Quantitative Biology 2011-05-11 Gabor Szederkenyi , Katalin M. Hangos
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