Related papers: Sparse optimal control of a phase field tumour mod…
In the present contribution we study the sliding mode control (SMC) problem for a diffuse interface tumor growth model coupling a viscous Cahn-Hilliard type equation for the phase variable with a reaction-diffusion equation for the…
This paper is concerned with a distributed optimal control problem for a nonlocal phase field model of Cahn-Hilliard type, which is a nonlocal version of a model for two-species phase segregation on an atomic lattice under the presence of…
In this paper we consider an optimal control problem arising from a chemotherapeutic drug treatment for tumor cells in a living tissue. The mathematical model for the interaction of chemotherapeutic drug and the normal, tumor and immune…
In this paper, we study an optimal control problem for a brain tumor growth model that incorporates lactate metabolism, viscoelastic effects, and tissue damage. The PDE system, introduced in [G. Cavalleri, P. Colli, A. Miranville, E. Rocca,…
In this paper we study the optimal control of a parabolic initial-boundary value problem of Allen--Cahn type with dynamic boundary conditions. Phase field systems of this type govern the evolution of coupled diffuse phase transition…
We consider the inverse problem of identifying parameters in a variant of the diffuse interface model for tumour growth model proposed by Garcke, Lam, Sitka and Styles (Math. Models Methods Appl. Sci. 2016). The model contains three…
We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor…
A mathematical model for time development of metastases and their distribution in size and carrying capacity is presented. The model is used to theoretically investigate anti-cancer therapies such as surgery and chemical treatments…
We investigate a distributed optimal control problem for the viscous Camassa--Holm equations with sparse controls and a general cost functional. Considering three different forms of sparsity-promoting terms, we prove the existence of…
This work focuses on optimal controls of a class of stochastic SIS epidemic models under regime switching. By assuming that a decision maker can either influence the infectivity period or isolate infected individuals, our aim is to minimize…
In this paper, we consider the optimal control of material micro-structures. Such material micro-structures are modeled by the so-called phase field model. We study the underlying physical structure of the model and propose a data based…
This article treats optimal sparse control problems with multiple constraints defined at intermediate points of the time domain. For such problems with intermediate constraints, we first establish a new Pontryagin maximum principle that…
An optimal control problem for a model of tumor growth is studied. In a given subdomain, it is required to minimize the density of tumor cells, while the drug concentration in tissue is limited by given minimal and maximal values. Based on…
This article discusses an optimal control problem for a phase field model of two immiscible incompressible fluid flow, incorporating surface tension effects. The optimal control problem is defined with a $L^2$-cost functional and subject to…
In this paper, we study a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. We show that the resulting…
We review the optimal control of systems modeling the dynamics of tuberculosis. Time dependent control functions are introduced in the mathematical models, representing strategies for the improvement of the treatment and cure of active…
In this paper, a tractable methodology is proposed to approximate stochastic optimal feedback treatment in the context of mixed immuno-chemo therapy of cancer. The method uses a fixed-point value iteration that approximately solves a…
In this paper, we tackle the problem of reconstructing earlier tumour configurations starting from a single spatial measurement at a later time. We describe the tumour evolution through a diffuse interface model coupling a…
In this work, we investigate optimal control of a Brinkman equation couple with sixth-order Cahn-Hilliard equation. The Cahn-Hilliard equation is endowed with a source term accounting for mass exchange and the velocity equation contains a…
In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…