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In many causal inference applications, only one or a few units (or clusters of units) are treated. An important challenge in such settings is that standard inference methods relying on asymptotic theory may be unreliable, even with large…

Econometrics · Economics 2026-05-22 Luis Alvarez , Bruno Ferman , Kaspar Wüthrich

We develop new algorithms for estimating heterogeneous treatment effects, combining recent developments in transfer learning for neural networks with insights from the causal inference literature. By taking advantage of transfer learning,…

Migration of cells can be characterized by two, prototypical types of motion: individual and collective migration. We propose a statistical-inference approach designed to detect the presence of cell-cell interactions that give rise to…

Cell Behavior · Quantitative Biology 2020-03-13 Elena Agliari , Pablo J. Sáez , Adriano Barra , Matthieu Piel , Pablo Vargas , Michele Castellana

The synthetic control method is often applied to problems with one treated unit and a small number of control units. A common inferential task in this setting is to test null hypotheses regarding the average treatment effect on the treated.…

Methodology · Statistics 2025-04-22 Lihua Lei , Timothy Sudijono

Understanding treatment effect heterogeneity is important for decision making in medical and clinical practices, or handling various engineering and marketing challenges. When dealing with high-dimensional covariates or when the effect…

We study the problem of a decision maker who must provide the best possible treatment recommendation based on an experiment. The desirability of the outcome distribution resulting from the policy recommendation is measured through a…

Econometrics · Economics 2022-04-06 Anders Bredahl Kock , David Preinerstorfer , Bezirgen Veliyev

Neural networks are powerful predictive models, but they provide little insight into the nature of relationships between predictors and outcomes. Although numerous methods have been proposed to quantify the relative contributions of input…

Methodology · Statistics 2023-01-30 Francesca Mandel , Ian Barnett

In an observational study, it is common to leverage known null effect to detect bias. One such strategy is to set aside a placebo sample -- a subset of data immune from the hypothesized cause-and-effect relationship. Existence of an effect…

Methodology · Statistics 2022-07-05 Ting Ye , Shuxiao Chen , Bo Zhang

In longitudinal studies where units are embedded in space or a social network, interference may arise, meaning that a unit's outcome can depend on treatment histories of others. The presence of interference poses significant challenges for…

Methodology · Statistics 2025-08-26 Ye Wang , Michael Jetsupphasuk

We consider a causal inference model in which individuals interact in a social network and they may not comply with the assigned treatments. In particular, we suppose that the form of network interference is unknown to researchers. To…

Methodology · Statistics 2023-10-24 Tadao Hoshino , Takahide Yanagi

In the course of animal development, the shape of tissue emerges in part from mechanical and biochemical interactions between cells. Measuring stress in tissue is essential for studying morphogenesis and its physical constraints.…

Quantitative Methods · Quantitative Biology 2013-01-21 S. Ishihara , K. Sugimura , S. J. Cox , I. Bonnet , Y. Bellaiche , F. Graner

Methods for causal inference from observational data are an alternative for scenarios where collecting counterfactual data or realizing a randomized experiment is not possible. Adopting a stacking approach, our proposed method ParKCA…

Machine Learning · Computer Science 2020-11-13 Raquel Aoki , Martin Ester

Imitation is a key component of human social behavior, and is widely used by both children and adults as a way to navigate uncertain or unfamiliar situations. But in an environment populated by multiple heterogeneous agents pursuing…

Neurons and Cognition · Quantitative Biology 2023-05-15 Max Taylor-Davies , Stephanie Droop , Christopher G. Lucas

Estimating treatment effects from observational data is of central interest across numerous application domains. Individual treatment effect offers the most granular measure of treatment effect on an individual level, and is the most useful…

Machine Learning · Statistics 2024-08-06 Hengrui Cai , Huaqing Jin , Lexin Li

This paper considers conducting inference about the effect of a treatment (or exposure) on an outcome of interest. In the ideal setting where treatment is assigned randomly, under certain assumptions the treatment effect is identifiable…

Methodology · Statistics 2015-03-06 Amy Richardson , Michael G. Hudgens , Peter B. Gilbert , Jason P. Fine

Kidney transplantation is the best treatment for end-stage renal failure patients. The predominant method used for kidney quality assessment is the Cox regression-based, kidney donor risk index. A machine learning method may provide…

Machine Learning · Computer Science 2020-12-08 Eric S. Pahl , W. Nick Street , Hans J. Johnson , Alan I. Reed

We examine study designs for extending (generalizing or transporting) causal inferences from a randomized trial to a target population. Specifically, we consider nested trial designs, where randomized individuals are nested within a sample…

The unfolding of detector effects is a key aspect of comparing experimental data with theoretical predictions. In recent years, different Machine-Learning methods have been developed to provide novel features, e.g. high dimensionality or a…

Data Analysis, Statistics and Probability · Physics 2024-12-17 Mathias Backes , Anja Butter , Monica Dunford , Bogdan Malaescu

In panel experiments, we randomly assign units to different interventions, measuring their outcomes, and repeating the procedure in several periods. Using the potential outcomes framework, we define finite population dynamic causal effects…

Methodology · Statistics 2021-05-28 Iavor Bojinov , Ashesh Rambachan , Neil Shephard

Identification of causal effects is one of the most fundamental tasks of causal inference. We consider an identifiability problem where some experimental and observational data are available but neither data alone is sufficient for the…

Artificial Intelligence · Computer Science 2019-03-13 Santtu Tikka , Juha Karvanen