Related papers: A Design-Based Model of the Aortic Valve for Fluid…
It has long been recognized that aortic root elasticity helps to ensure efficient aortic valve closure, but our understanding of the functional importance of the elasticity and geometry of the aortic root continues to evolve as increasingly…
We introduce an innovative lumped-parameter model of the aortic valve, designed to efficiently simulate the impact of valve dynamics on blood flow. Our reduced model includes the elastic effects associated with the leaflets' curvature and…
The immersed boundary (IB) method is a mathematical and numerical framework for problems of fluid-structure interaction, treating the particular case in which an elastic structure is immersed in a viscous incompressible fluid. The IB…
This thesis is concerned with modeling and simulation of the mitral valve, one of the four valves in the human heart. The valve is composed of leaflets attached to a ring, the free edges of which are supported by a system of chordae, which…
This work is concerned with modeling and simulation of the mitral valve, one of the four valves in the human heart. The valve is composed of leaflets, the free edges of which are supported by a system of chordae, which themselves are…
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…
Subclinical leaflet thrombosis (SLT) is a potentially serious complication of aortic valve replacement with a bioprosthetic valve in which blood clots form on the replacement valve. SLT is associated with increased risk of transient…
Valvular heart diseases are growing concern in impoverished parts of the world, such as Southern-Africa, claiming more than 31 % of total deaths related to cardiovascular diseases. The ability to model the effects of regurgitant and…
The present paper is concerned with numerical investigation of the performance of a pilot-operated control valve based on shape memory alloy actuation control. The valve under investigation can be integrated into miniaturized hydraulic…
The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly…
Systematic in vivo validations of computational models of the aortic valve remain scarce, despite successful validation against in vitro data. Utilizing a combination of computed tomography and 4D flow magnetic resonance imaging data, we…
Mathematical models are widely recognized as a valuable tool for cardiovascular diagnosis and the study of circulatory diseases, especially to obtain data that require otherwise invasive measurements. To correctly simulate body…
Understanding the interaction between the valves and walls of the heart is important in assessing and subsequently treating heart dysfunction. With advancements in cardiac imaging, nonlinear mechanics and computational techniques, it is now…
A noteworthy aspect in blood flow modeling is the definition of the mechanical interaction between the fluid flow and the biological structure that contains it, namely the vessel wall. It has been demonstrated that the addition of a viscous…
The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction…
To accurately simulate all phases of the cardiac cycle, computational models of hemodynamics in heart chambers need to include a sufficiently faithful model of cardiac valves. This can be achieved efficiently through resistive methods, and…
We propose a suite of technologies for analyzing the interaction between anisotropic arterial walls and blood flow for subject-specific geometries. Utilizing an established lumen modeling strategy, we present a comprehensive pipeline for…
Cardiac blood flow patterns contain rich information about disease severity and clinical interventions, yet current imaging and computational methods fail to capture underlying relational structures of coherent flow features. We propose a…
We present a new approach for the mechanically consistent modelling and simulation of fluid-structure interactions with contact. The fundamental idea consists of combining a relaxed contact formulation with the modelling of seepage through…
This work reports on a study to develop a patient-specific finite element model of the Transcatheter Aortic Valve Implantation procedure, using a model of a balloon-expandable percutaneous prosthetic aortic valve as a framework for the…