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Perfusion imaging is the current gold standard for acute ischemic stroke analysis. It allows quantification of the salvageable and non-salvageable tissue regions (penumbra and core areas respectively). In clinical settings, the singular…

Image and Video Processing · Electrical Eng. & Systems 2021-04-01 Ezequiel de la Rosa , David Robben , Diana M. Sima , Jan S. Kirschke , Bjoern Menze

Perfusion imaging plays a crucial role in acute stroke diagnosis and treatment decision making. Current perfusion analysis relies on deconvolution of the measured signals, an operation that is mathematically ill-conditioned and requires…

Computer Vision and Pattern Recognition · Computer Science 2018-10-12 David Robben , Paul Suetens

Quantification of myocardial perfusion has the potential to improve detection of regional and global flow reduction. Significant effort has been made to automate the workflow, where one essential step is the arterial input function (AIF)…

Quantitative Methods · Quantitative Biology 2020-05-11 Hui Xue , Ethan Tseng , Kristopher D Knott , Tushar Kotecha , Louise Brown , Sven Plein , Marianna Fontana , James C Moon , Peter Kellman

Purpose: In this study we investigate whether a Convolutional Neural Network (CNN) can generate clinically relevant parametric maps from CT perfusion data in a clinical setting of patients with acute ischemic stroke. Methods: Training of…

Image and Video Processing · Electrical Eng. & Systems 2021-01-18 Umberto A. Gava , Federico D'Agata , Enzo Tartaglione , Marco Grangetto , Francesca Bertolino , Ambra Santonocito , Edwin Bennink , Mauro Bergui

CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We…

Accurate detection of arterial input function is a crucial step in obtaining perfusion hemodynamic parameters using dynamic susceptibility contrast-enhanced magnetic resonance imaging. It is required as input for perfusion quantification…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Svitlana Alkhimova , Kateryna Sazonova

Purpose: To develop biophysics-based method for estimating perfusion Q from arterial spin labeling (ASL) images using deep learning. Methods: A 3D U-Net (QTMnet) was trained to estimate perfusion from 4D tracer propagation images. The…

Quantitative Methods · Quantitative Biology 2023-11-20 Renjiu Hu , Qihao Zhang , Pascal Spincemaille , Thanh D. Nguyen , Yi Wang

Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is widely used to evaluate acute ischemic stroke to distinguish salvageable tissue and infarct core. For this purpose, traditional methods employ deconvolution techniques,…

Image and Video Processing · Electrical Eng. & Systems 2023-12-12 Anbo Cao , Pin-Yu Le , Zhonghui Qie , Haseeb Hassan , Yingwei Guo , Asim Zaman , Jiaxi Lu , Xueqiang Zeng , Huihui Yang , Xiaoqiang Miao , Taiyu Han , Guangtao Huang , Yan Kang , Yu Luo , Jia Guo

Dynamic computed tomography perfusion (CTP) imaging is a promising approach for acute ischemic stroke diagnosis and evaluation. Hemodynamic parametric maps of cerebral parenchyma are calculated from repeated CT scans of the first pass of…

Medical Physics · Physics 2020-05-21 Dufan Wu , Hui Ren , Quanzheng Li

More than 13 million people suffer from ischemic cerebral stroke worldwide each year. Thrombolytic treatment can reduce brain damage but has a narrow treatment window. Computed Tomography Perfusion imaging is a commonly used primary…

Image and Video Processing · Electrical Eng. & Systems 2021-04-22 Luca Tomasetti , Kjersti Engan , Mahdieh Khanmohammadi , Kathinka Dæhli Kurz

Pleural effusion semantic segmentation can significantly enhance the accuracy and timeliness of clinical diagnosis and treatment by precisely identifying disease severity and lesion areas. Currently, semantic segmentation of pleural…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Ruixiang Tang , Mingda Zhang , Jianglong Qin , Yan Song , Yi Wu , Wei Wu

This paper explores the use of deep learning-based computer vision for real-time monitoring of the flow in intravenous (IV) infusions. IV infusions are among the most common therapies in hospitalized patients and, given that both…

Computer Vision and Pattern Recognition · Computer Science 2020-11-24 Nicola Giaquinto , Marco Scarpetta , Maurizio Spadavecchia , Gregorio Andria

Precise and fast prediction methods for ischemic areas comprised of dead tissue, core, and salvageable tissue, penumbra, in acute ischemic stroke (AIS) patients are of significant clinical interest. They play an essential role in improving…

Image and Video Processing · Electrical Eng. & Systems 2023-12-06 Luca Tomasetti , Kjersti Engan , Liv Jorunn Høllesli , Kathinka Dæhli Kurz , Mahdieh Khanmohammadi

Focal deficits in ischaemic stroke result from impaired perfusion downstream of a critical vascular occlusion. While parenchymal lesions are traditionally used to predict clinical deficits, the underlying pattern of disrupted perfusion…

Time is a fundamental factor during stroke treatments. A fast, automatic approach that segments the ischemic regions helps treatment decisions. In clinical use today, a set of color-coded parametric maps generated from computed tomography…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Luca Tomasetti , Mahdieh Khanmohammadi , Kjersti Engan , Liv Jorunn Høllesli , Kathinka Dæhli Kurz

The patient with ischemic stroke can benefit most from the earliest possible definitive diagnosis. While the high quality medical resources are quite scarce across the globe, an automated diagnostic tool is expected in analyzing the…

Computer Vision and Pattern Recognition · Computer Science 2018-03-16 Zhiyang Liu , Chen Cao , Shuxue Ding , Tong Han , Hong Wu , Sheng Liu

Physics-informed neural networks (PINNs) have shown promise in addressing the ill-posed deconvolution problem in computed tomography perfusion (CTP) imaging for acute ischemic stroke assessment. However, existing PINN-based approaches…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Junhyeok Lee , Minseo Choi , Han Jang , Young Hun Jeon , Heeseong Eum , Joon Jang , Chul-Ho Sohn , Kyu Sung Choi

Intracerebral Hemorrhage (ICH) is a severe condition resulting from damaged brain blood vessel ruptures, often leading to complications and fatalities. Timely and accurate prognosis and management are essential due to its high mortality…

Image and Video Processing · Electrical Eng. & Systems 2023-11-09 Xuhao Shan , Xinyang Li , Ruiquan Ge , Shibin Wu , Ahmed Elazab , Jichao Zhu , Lingyan Zhang , Gangyong Jia , Qingying Xiao , Xiang Wan , Changmiao Wang

Delineating infarcted tissue in ischemic stroke lesions is crucial to determine the extend of damage and optimal treatment for this life-threatening condition. However, this problem remains challenging due to high variability of ischemic…

Computer Vision and Pattern Recognition · Computer Science 2018-10-17 Jose Dolz , Ismail Ben Ayed , Christian Desrosiers

DSC-MRI perfusion is a medical imaging technique for diagnosing and prognosing brain tumors and strokes. Its analysis relies on mathematical deconvolution, but noise or motion artifacts in a clinical environment can disrupt this process,…

Quantitative Methods · Quantitative Biology 2025-10-17 Pierre Fayolle , Alexandre Bône , Noëlie Debs , Mathieu Naudin , Pascal Bourdon , Remy Guillevin , David Helbert
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