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Molecular dynamics (MD) simulations are widely used to study biological systems, where water molecules often play a critical role in protein-ligand interactions. In conventional MD preparation protocols, water molecules are typically added…

Chemical Physics · Physics 2026-04-30 Felipe Silva Carvalho , Steven Ramsey , Tom Kurtzman , Tyler Luchko

Efficient, accurate, and adaptable implicit solvent models remain a significant challenge in the field of molecular simulation. A recent implicit solvent model, IS-SPA, based on approximating the mean solvent force using the superposition…

Chemical Physics · Physics 2023-01-11 Peter T. Lake , Max A. Mattson , Martin McCullagh

Theoretical studies of protein folding on lattice models relie on the assumption that water close to amino-acids is always in thermal equilibrium all along the folding pathway. Within this framework, it has always been considered that…

Biological Physics · Physics 2012-02-08 Olivier Collet

We propose a new algorithm to learn the network of the interactions of pairwise Ising models. The algorithm is based on the pseudo-likelihood method (PLM), that has already been proven to efficiently solve the problem in a large variety of…

Disordered Systems and Neural Networks · Physics 2019-02-19 Silvio Franz , Federico Ricci-Tersenghi , Jacopo Rocchi

Chemical potential of species in solution is essential for understanding various chemical processes at interfaces. Molecular dynamics (MD) simulations, constrained by fixed compositions, cannot satisfy a constant chemical potential…

Chemical Physics · Physics 2025-06-03 Ademola Soyemi , Khagendra Baral , Tibor Szilvasi

Hybrid particle-field methods are computationally efficient approaches for modelling soft matter systems. So far applications of these methodologies have been limited to constant volume conditions. Here, we reformulate particle-field…

We establish a biophysical model for the dynamics of lipid vesicles exposed to surfactants. The solubilization of the lipid membrane due to the insertion of surfactant molecules induces a reduction of membrane surface area at almost…

Biological Physics · Physics 2019-04-24 Morgan Chabanon , Padmini Rangamani

We present a methodology for simulating dilute suspensions of particles settling under gravity, with the main purpose of overcoming limitations of triply periodic configurations, mainly the strong vertical correlation that hinders the study…

Fluid Dynamics · Physics 2026-04-24 M. Moriche , M. García-Villalba , M. Uhlmann

This article presents a multi-physics methodology for the numerical simulation of physical systems that involve the non-linear interaction of multi-phase reactive fluids and elastoplastic solids, inducing high strain-rates and high…

Computational Physics · Physics 2021-06-04 Tim Wallis , Philip T. Barton , Nikolaos Nikiforakis

Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations…

Biomolecules · Quantitative Biology 2016-11-04 Osman Kahraman , Peter D. Koch , William S. Klug , Christoph A. Haselwandter

We present a multi-level elastodynamics timestep solver for accelerating incremental potential contact (IPC) simulations. Our method retains the robustness of gold standard IPC in the face of intricate geometry, complex heterogeneous…

Graphics · Computer Science 2025-08-20 Ty Trusty , David I. W. Levin , Danny M. Kaufman

Knowledge of the underlying mechanisms of multiphase flow dynamics in porous media is crucial for optimizing subsurface engineering applications like geological carbon sequestration. However, studying the micro-mechanisms of multiphase…

Fluid Dynamics · Physics 2025-08-01 Quanwei Dai , Kang Duan , Chung-Yee Kwok

In experimental systems, colloidal particles are virtually always at least somewhat polydisperse, which can have profound effects on their ability to crystallize. Unfortunately, accurately predicting the effects of polydispersity on phase…

Soft Condensed Matter · Physics 2025-10-09 Antoine Castagnède , Laura Filion , Frank Smallenburg

Elastin-like polypeptides (ELPs) undergo a sharp solubility transition from low temperature solvated phases to coacervates at elevated temperatures, driven by the increased strength of hydrophobic interactions at higher temperatures. The…

Soft Condensed Matter · Physics 2020-07-23 Upayan Baul , Michael Bley , Joachim Dzubiella

Particle-In-Cell (PIC) methods are frequently used for kinetic, high-fidelity simulations of plasmas. Implicit formulations of PIC algorithms feature strong conservation properties, up to numerical round-off errors, and are not subject to…

Plasma Physics · Physics 2021-10-26 R. Kube , R. M. Churchill , B. Sturdevant

A two-state-model consisting of hexagonally connected lipids being either in the ordered or disordered state is used to set up a Monte Carlo Simulation for lipid monolayers. The connection of the lipids is realized by Newtonian springs…

Biological Physics · Physics 2011-07-27 J. Griesbauer , A. Wixforth , H. M. Seeger , M. F. Schneider

The hydrodynamic interactions of a suspension of self-propelled particles are studied using a direct numerical simulation method which simultaneously solves for the host fluid and the swimming particles. A modified version of the "Smoothed…

Soft Condensed Matter · Physics 2013-01-15 John J. Molina , Yasuya Nakayama , Ryoichi Yamamoto

We present a quasi-static finite element simulator for human face animation. We model the face as an actuated soft body, which can be efficiently simulated using Projective Dynamics (PD). We adopt Incremental Potential Contact (IPC) to…

Graphics · Computer Science 2023-12-07 Bo Li , Lingchen Yang , Barbara Solenthaler

A novel numerical technique designed for interface flow simulations using the Volume of Fluid (VOF) method on arbitrary unstructured meshes has been introduced. The method is called SimPLIC, which seamlessly integrates Piecewise Linear…

Fluid Dynamics · Physics 2024-02-09 Dezhi Dai , Haomin Yuan , Albert Y. Tong , Adrian Tentner

Previously, we have proposed a direct simulation scheme for colloidal dispersions in a Newtonian solvent [Phys.Rev.E 71,036707 (2005)]. An improved formulation called the ``Smoothed Profile (SP) method'' is presented here in which…

Soft Condensed Matter · Physics 2010-04-15 Yasuya Nakayama , Kang Kim , Ryoichi Yamamoto