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In various statistical settings, the goal is to estimate a function which is restricted by the statistical model only through a conditional moment restriction. Prominent examples include the nonparametric instrumental variable framework for…

Methodology · Statistics 2025-05-28 AmirEmad Ghassami , James M. Robins , Andrea Rotnitzky

The case-control sampling design serves as a pivotal strategy in mitigating the imbalanced structure observed in binary data. We consider the estimation of a non-parametric logistic model with the case-control data supplemented by external…

Machine Learning · Statistics 2024-09-04 Hengchao Shi , Ming Zheng , Wen Yu

Doubly robust estimators are widely used for estimating average treatment effects and other linear summaries of regression functions. While consistency requires only one of two nuisance functions to be estimated consistently, asymptotic…

Methodology · Statistics 2025-07-01 Lars van der Laan , Alex Luedtke , Marco Carone

In empirical studies with time-to-event outcomes, investigators often leverage observational data to conduct causal inference on the effect of exposure when randomized controlled trial data is unavailable. Model misspecification and lack of…

Methodology · Statistics 2023-05-05 Shenbo Xu , Bang Zheng , Bowen Su , Stan Finkelstein , Roy Welsch , Kenney Ng , Ioanna Tzoulaki , Zach Shahn

The double/debiased machine learning (DML) framework has become a cornerstone of modern causal inference, allowing researchers to utilise flexible machine learning models for the estimation of nuisance functions without introducing…

Econometrics · Economics 2025-06-19 Charles Shaw

Structure-agnostic causal inference studies how well one can estimate a treatment effect given black-box machine learning estimates of nuisance functions (like the impact of confounders on treatment and outcomes). Here, we find that the…

Machine Learning · Statistics 2025-11-10 Jikai Jin , Lester Mackey , Vasilis Syrgkanis

In the last decade, machine learning techniques have gained popularity for estimating causal effects. One machine learning approach that can be used for estimating an average treatment effect is Double/debiased machine learning (DML)…

Econometrics · Economics 2025-01-17 Daniele Ballinari , Nora Bearth

We develop a unified framework for automatic debiased machine learning (autoDML) for inference on a broad class of statistical parameters. The framework applies to any smooth functional of a nonparametric M-estimand, defined as the…

Methodology · Statistics 2026-03-23 Lars van der Laan , Aurelien Bibaut , Nathan Kallus , Alex Luedtke

Double machine learning is a statistical method for leveraging complex black-box models to construct approximately unbiased treatment effect estimates given observational data with high-dimensional covariates, under the assumption of a…

Machine Learning · Statistics 2022-06-03 Nitai Fingerhut , Matteo Sesia , Yaniv Romano

Double Machine Learning is often justified by nuisance-rate conditions, yet finite-sample reliability also depends on the conditioning of the orthogonal-score Jacobian. This conditioning is typically assumed rather than tracked. When…

Methodology · Statistics 2026-01-08 Gabriel Saco

One way to quantify exposure to air pollution and its constituents in epidemiologic studies is to use an individual's nearest monitor. This strategy results in potential inaccuracy in the actual personal exposure, introducing bias in…

Although various distributed machine learning schemes have been proposed recently for pure linear models and fully nonparametric models, little attention has been paid on distributed optimization for semi-paramemetric models with…

Machine Learning · Statistics 2019-11-05 Shaogao Lv , Heng Lian

Orthogonal statistical learning and double machine learning have emerged as general frameworks for two-stage statistical prediction in the presence of a nuisance component. We establish non-asymptotic bounds on the excess risk of orthogonal…

Machine Learning · Statistics 2022-06-22 Lang Liu , Carlos Cinelli , Zaid Harchaoui

This paper proposes a doubly robust two-stage semiparametric difference-in-difference estimator for estimating heterogeneous treatment effects with high-dimensional data. Our new estimator is robust to model miss-specifications and allows…

Econometrics · Economics 2020-09-08 Yang Ning , Sida Peng , Jing Tao

The validity of two-step or plug-in inference methods is questioned in the Bayesian framework. We study semi-parametric models where the plug-in of a non-parametrically modelled nuisance component is used. We show that when the nuisance and…

Statistics Theory · Mathematics 2026-02-25 Magid Sabbagh , David A. Stephens

Deep Metric Learning (DML) plays a critical role in various machine learning tasks. However, most existing deep metric learning methods with binary similarity are sensitive to noisy labels, which are widely present in real-world data. Since…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Jiexi Yan , Lei Luo , Cheng Deng , Heng Huang

Latent variable models provide a powerful framework for incorporating and inferring unobserved factors in observational data. In causal inference, they help account for hidden factors influencing treatment or outcome, thereby addressing…

Machine Learning · Computer Science 2025-08-29 Tetsuro Morimura , Tatsushi Oka , Yugo Suzuki , Daisuke Moriwaki

When studying treatment effects in multilevel studies, investigators commonly use (semi-)parametric estimators, which make strong parametric assumptions about the outcome, the treatment, and/or the correlation structure between study units…

Methodology · Statistics 2022-05-12 Chan Park , Hyunseung Kang

We provide non-asymptotic excess risk guarantees for statistical learning in a setting where the population risk with respect to which we evaluate the target parameter depends on an unknown nuisance parameter that must be estimated from…

Statistics Theory · Mathematics 2023-06-07 Dylan J. Foster , Vasilis Syrgkanis

This paper investigates double/debiased machine learning (DML) under multiway clustered sampling environments. We propose a novel multiway cross fitting algorithm and a multiway DML estimator based on this algorithm. We also develop a…

Econometrics · Economics 2020-03-05 Harold D. Chiang , Kengo Kato , Yukun Ma , Yuya Sasaki