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Whole slide image (WSI) refers to a type of high-resolution scanned tissue image, which is extensively employed in computer-assisted diagnosis (CAD). The extremely high resolution and limited availability of region-level annotations make…
In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch…
Multiple Instance Learning (MIL) methods allow for gigapixel Whole-Slide Image (WSI) analysis with only slide-level annotations. Interpretability is crucial for safely deploying such algorithms in high-stakes medical domains. Traditional…
Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…
Introducing interpretability and reasoning into Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) analysis is challenging, given the complexity of gigapixel slides. Traditionally, MIL interpretability is limited to…
Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…
Multiple Instance Learning (MIL) and transformers are increasingly popular in histopathology Whole Slide Image (WSI) classification. However, unlike human pathologists who selectively observe specific regions of histopathology tissues under…
Despite remarkable efforts been made, the classification of gigapixels whole-slide image (WSI) is severely restrained from either the constrained computing resources for the whole slides, or limited utilizing of the knowledge from different…
Interpreting machine learning model decisions is crucial for high-risk applications like healthcare. In digital pathology, large whole slide images (WSIs) are decomposed into smaller tiles and tile-derived features are processed by…
Multiple Instance Learning (MIL) has been widely applied in histopathology to classify Whole Slide Images (WSIs) with slide-level diagnoses. While the ground truth is established by expert pathologists, the slides can be difficult to…
Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…
The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…
Interpretability is essential in Whole Slide Image (WSI) analysis for computational pathology, where understanding model predictions helps build trust in AI-assisted diagnostics. While Integrated Gradients (IG) and related attribution…
Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…
Prevention and early diagnosis of breast cancer (BC) is an essential prerequisite for the selection of proper treatment. The substantial pressure due to the increase of demand for faster and more precise diagnostic results drives for…
Encoding whole slide images (WSI) as graphs is well motivated since it makes it possible for the gigapixel resolution WSI to be represented in its entirety for the purpose of graph learning. To this end, WSIs can be broken into smaller…
Whole slide images (WSIs) are the gold standard for pathological diagnosis and sub-typing. Current main-stream two-step frameworks employ offline feature encoders trained without domain-specific knowledge. Among them, attention-based…
Digital whole slide images (WSIs) are generally captured at microscopic resolution and encompass extensive spatial data. Directly feeding these images to deep learning models is computationally intractable due to memory constraints, while…
Algorithmic decision support is rapidly becoming a staple of personalized medicine, especially for high-stakes recommendations in which access to certain information can drastically alter the course of treatment, and thus, patient outcome;…
Whole Slide Imaging (WSI) is a cornerstone of digital pathology, offering detailed insights critical for diagnosis and research. Yet, the gigapixel size of WSIs imposes significant computational challenges, limiting their practical utility.…