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X-ray imaging dose from serial cone-beam CT (CBCT) scans raises a clinical concern in most image guided radiation therapy procedures. It is the goal of this paper to develop a fast GPU-based algorithm to reconstruct high quality CBCT images…

Medical Physics · Physics 2015-05-19 Xun Jia , Bin Dong , Yifei Lou , Steve B. Jiang

Low-dose computed tomography (LDCT) plays a vital role in clinical applications by mitigating radiation risks. Nevertheless, reducing radiation doses significantly degrades image quality. Concurrently, common deep learning methods demand…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Wenhao Zhang , Bin Huang , Shuyue Chen , Xiaoling Xu , Weiwen Wu , Qiegen Liu

Reconstruction of few-view x-ray Computed Tomography (CT) data is a highly ill-posed problem. It is often used in applications that require low radiation dose in clinical CT, rapid industrial scanning, or fixed-gantry CT. Existing analytic…

Image and Video Processing · Electrical Eng. & Systems 2019-10-15 Hyojin Kim , Rushil Anirudh , K. Aditya Mohan , Kyle Champley

Recently, a number of approaches to low-dose computed tomography (CT) have been developed and deployed in commercialized CT scanners. Tube current reduction is perhaps the most actively explored technology with advanced image reconstruction…

Medical Physics · Physics 2018-09-05 Hoyeon Lee , Jongha Lee , Hyeongseok Kim , Byungchul Cho , Seungryong Cho

Image reconstruction from insufficient data is common in computed tomography (CT), e.g., image reconstruction from truncated data, limited-angle data and sparse-view data. Deep learning has achieved impressive results in this field.…

Image and Video Processing · Electrical Eng. & Systems 2020-05-21 Yixing Huang , Alexander Preuhs , Michael Manhart , Guenter Lauritsch , Andreas Maier

Radiomics is an active area of research in medical image analysis, the low reproducibility of radiomics has limited its applicability to clinical practice. This issue is especially prominent when radiomic features are calculated from noisy…

Quantitative Methods · Quantitative Biology 2021-08-16 Junhua Chen , Chong Zhang , Alberto Traverso , Ivan Zhovannik , Andre Dekker , Leonard Wee , Inigo Bermejo

Computed Tomography (CT) is widely used in healthcare for detailed imaging. However, Low-dose CT, despite reducing radiation exposure, often results in images with compromised quality due to increased noise. Traditional methods, including…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Herman Verinaz-Jadan , Su Yan

Cone-beam breast computed tomography (CT) provides true 3D breast images with isotropic resolution and high-contrast information, detecting calcifications as small as a few hundred microns and revealing subtle tissue differences. However,…

Medical Physics · Physics 2019-12-18 Wenxiang Cong , Hongming Shan , Xiaohua Zhang , Shaohua Liu , Ruola Ning , Ge Wang

Low-dose Computed Tomography (LDCT) reconstruction is an important task in medical image analysis. Recent years have seen many deep learning based methods, proved to be effective in this area. However, these methods mostly follow a…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Runyi Li

Low-dose CT denoising is a challenging task that has been studied by many researchers. Some studies have used deep neural networks to improve the quality of low-dose CT images and achieved fruitful results. In this paper, we propose a deep…

Image and Video Processing · Electrical Eng. & Systems 2019-02-28 Maryam Gholizadeh-Ansari , Javad Alirezaie , Paul Babyn

The resurgence of deep neural networks has created an alternative pathway for low-dose computed tomography denoising by learning a nonlinear transformation function between low-dose CT (LDCT) and normal-dose CT (NDCT) image pairs. However,…

Image and Video Processing · Electrical Eng. & Systems 2022-11-04 Sutanu Bera , Prabir Kumar Biswas

Low-dose computed tomography (LDCT) reconstruction is fundamentally challenged by severe noise and compromised data fidelity under reduced radiation exposure. Most existing methods operate either in the image or post-log projection domain,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Bin Huang , Xun Yu , Yikun Zhang , Yi Zhang , Yang Chen , Qiegen Liu

Score-based generative models (SGMs) have gained prominence in sparse-view CT reconstruction for their precise sampling of complex distributions. In SGM-based reconstruction, data consistency in the score-based diffusion model ensures close…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Weiwen Wu , Yanyang Wang

Cone beam computed tomography (CBCT)-guided puncture has become an established approach for diagnosing and treating early- to mid-stage thoracic tumours, yet the associated radiation exposure substantially elevates the risk of secondary…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Haoshen Wang , Lei Chen , Wei-Hua Zhang , Linxia Wu , Yong Luo , Zengmao Wang , Yuan Xiong , Chengcheng Zhu , Wenjuan Tang , Xueyi Zhang , Wei Zhou , Xuhua Duan , Lefei Zhang , Gao-Jun Teng , Bo Du , Huangxuan Zhao

Ionizing radiation has been the biggest concern in CT imaging. To reduce the dose level without compromising the image quality, low-dose CT reconstruction has been offered with the availability of compressed sensing based reconstruction…

Image and Video Processing · Electrical Eng. & Systems 2025-11-14 Mehmet Ozan Unal , Metin Ertas , Isa Yildirim

We introduce Diffusion Active Learning, a novel approach that combines generative diffusion modeling with data-driven sequential experimental design to adaptively acquire data for inverse problems. Although broadly applicable, we focus on…

Machine Learning · Computer Science 2025-04-07 Luis Barba , Johannes Kirschner , Tomas Aidukas , Manuel Guizar-Sicairos , Benjamín Béjar

Low Dose CT Denoising research aims to reduce the risks of radiation exposure to patients. Recently researchers have used deep learning to denoise low dose CT images with promising results. However, approaches that use mean-squared-error…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Sepehr Ataei , Javad Alirezaie , Paul Babyn

Low-dose computed tomography (LDCT) reduces radiation exposure but suffers from image artifacts and loss of detail due to quantum and electronic noise, potentially impacting diagnostic accuracy. Transformer combined with diffusion models…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Qiqing Liu , Guoquan Wei , Zekun Zhou , Yiyang Wen , Liu Shi , Qiegen Liu

This paper proposes a deep learning-based denoising method for noisy low-dose computerized tomography (CT) images in the absence of paired training data. The proposed method uses a fidelity-embedded generative adversarial network (GAN) to…

Computer Vision and Pattern Recognition · Computer Science 2019-08-13 Hyoung Suk Park , Jineon Baek , Sun Kyoung You , Jae Kyu Choi , Jin Keun Seo

The generalization of deep learning-based low-dose computed tomography (CT) reconstruction models to doses unseen in the training data is important and remains challenging. Previous efforts heavily rely on paired data to improve the…

Image and Video Processing · Electrical Eng. & Systems 2025-06-30 Qi Gao , Zhihao Chen , Dong Zeng , Junping Zhang , Jianhua Ma , Hongming Shan