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We discuss nonparametric estimators of the distribution of the incubation time of a disease. The classical approach in these models is to use parametric families like Weibull, log-normal or gamma in the estimation procedure. We analyze…

Statistics Theory · Mathematics 2023-02-01 Piet Groeneboom

Nonparametric maximum likelihood estimators (MLEs) in inverse problems often have non-normal limit distributions, like Chernoff's distribution. However, if one considers smooth functionals of the model, with corresponding functionals of the…

Statistics Theory · Mathematics 2023-10-24 Piet Groeneboom

To reduce the biases of traditional survey-based methods, this paper proposes an epidemic model-based approach to inference the incubation period distribution of COVID-19 utilizing the publicly reported confirmed case number. We construct…

Populations and Evolution · Quantitative Biology 2020-07-23 Shiyang Lai , Tianqi Zhao , Ningyuan Fan

The distribution of the incubation period of the novel coronavirus disease that emerged in 2019 (COVID-19) has crucial clinical implications for understanding this disease and devising effective disease-control measures. Qin et al. (2020)…

Methodology · Statistics 2023-08-09 Chunlin Wang , Pengfei Li , Yukun Liu , Xiao-Hua Zhou , Jing Qin

We analyze nonparametric estimators for the distribution function of the incubation time in the singly and doubly interval censoring model. The classical approach is to use parametric families like Weibull, log-normal or gamma distributions…

Statistics Theory · Mathematics 2024-01-02 Piet Groeneboom

We consider the problem of estimating the distribution function, the density and the hazard rate of the (unobservable) event time in the current status model. A well studied and natural nonparametric estimator for the distribution function…

Statistics Theory · Mathematics 2010-01-13 Piet Groeneboom , Geurt Jongbloed , Birgit I. Witte

We consider the nonparametric maximum likelihood estimation for the underlying event time based on mixed-case interval-censored data, under a log-concavity assumption on its distribution function. This generalized framework relaxes the…

Computation · Statistics 2024-12-02 Chi Wing Chu , Hok Kan Ling , Chaoyu Yuan

The spread of COVID-19 makes it essential to investigate its prevalence. In such investigation research, as far as we know, the widely-used sampling methods didn't use the information sufficiently about the numbers of the previously…

Applications · Statistics 2022-01-04 Ze Liu , Siyu Yi , Jianghu , Dong , Min-Qian Liu , Yongdao Zhou

Epidemiological models with constant parameters may not capture satisfactory infection patterns in the presence of pharmaceutical and non-pharmaceutical mitigation measures during a pandemic, since infectiousness is a function of time. In…

Populations and Evolution · Quantitative Biology 2022-05-16 K. D. Olumoyin , A. Q. M. Khaliq , K. M. Furati

Viral outbreaks, such as the current COVID-19 pandemic, are commonly described by compartmental models by means of ordinary differential equation (ODE) systems. The parameter values of these ODE models are typically unknown and need to be…

Populations and Evolution · Quantitative Biology 2021-11-19 Jacques Hermes , Marcus Rosenblatt , Christian Tönsing , Jens Timmer

This paper deals with the problem of estimating variables in nonlinear models for the spread of disease and its application to the COVID-19 epidemic. First unconstrained methods are revisited and they are shown to correspond to the…

Optimization and Control · Mathematics 2020-08-20 Mauricio C. de Oliveira

The outbreak of Coronavirus Disease 2019 (COVID-19) is an ongoing pandemic affecting over 200 countries and regions. Inference about the transmission dynamics of COVID-19 can provide important insights into the speed of disease spread and…

Methodology · Statistics 2020-07-06 Tianjian Zhou , Yuan Ji

Non-parametric maximum likelihood estimation encompasses a group of classic methods to estimate distribution-associated functions from potentially censored and truncated data, with extensive applications in survival analysis. These methods,…

Methodology · Statistics 2021-08-05 Justin D. Tubbs , Lane Guolan Chen , Thuan Quoc Thach , Pak C. Sham

Typically, mathematical simulation studies on COVID-19 pandemic forecasting are based on deterministic differential equations which assume that both the number ($n$) of individuals in various epidemiological classes and the time ($t$) on…

Physics and Society · Physics 2020-09-08 Ioan Baldea

Daily pandemic surveillance, often achieved through the estimation of the reproduction number, constitutes a critical challenge for national health authorities to design countermeasures. In an earlier work, we proposed to formulate the…

Signal Processing · Electrical Eng. & Systems 2022-06-29 Barbara Pascal , Patrice Abry , Nelly Pustelnik , Stéphane G. Roux , Rémi Gribonval , Patrick Flandrin

Spatiotemporal modelling of infectious diseases such as COVID-19 involves using a variety of epidemiological metrics such as regional proportion of cases or regional positivity rates. Although observing their changes over time is critical…

Mixture models are regularly used in density estimation applications, but the problem of estimating the mixing distribution remains a challenge. Nonparametric maximum likelihood produce estimates of the mixing distribution that are…

Computation · Statistics 2019-06-28 Minwoo Chae , Ryan Martin , Stephen G. Walker

We provide a predictive analysis of the spread of COVID-19, also known as SARS-CoV-2, using the dataset made publicly available online by the Johns Hopkins University. Our main objective is to provide predictions of the number of infected…

Machine Learning · Computer Science 2020-05-26 Alireza M. Javid , Xinyue Liang , Arun Venkitaraman , Saikat Chatterjee

Classical epidemiological models assume homogeneous populations. There have been important extensions to model heterogeneous populations, when the identity of the sub-populations is known, such as age group or geographical location. Here,…

Machine Learning · Computer Science 2023-02-10 Roberto Vega , Zehra Shah , Pouria Ramazi , Russell Greiner

The emergence of infectious disease COVID-19 has challenged and changed the world in an unprecedented manner. The integration of wireless networks with edge computing (namely wireless edge networks) brings opportunities to address this…

Social and Information Networks · Computer Science 2022-10-06 Xuran Li , Shuaishuai Guo , Hong-Ning Dai , Dengwang Li
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