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Predicting protein secondary structure is essential for understanding protein function and advancing drug discovery. However, the intricate sequence-structure relationship poses significant challenges for accurate modeling. To address…

Machine Learning · Computer Science 2026-03-16 Yining Qian , Lijie Su , Meiling Xu , Xianpeng Wang

Gradient Symbolic Computation is proposed as a means of solving discrete global optimization problems using a neurally plausible continuous stochastic dynamical system. Gradient symbolic dynamics involves two free parameters that must be…

Computation and Language · Computer Science 2018-01-12 Paul Tupper , Paul Smolensky , Pyeong Whan Cho

Multilingual representations have mostly been evaluated based on their performance on specific tasks. In this article, we look beyond engineering goals and analyze the relations between languages in computational representations. We…

Computation and Language · Computer Science 2020-11-18 Lisa Beinborn , Rochelle Choenni

State-of-the-art models in semantic segmentation primarily operate on single, static images, generating corresponding segmentation masks. This one-shot approach leaves little room for error correction, as the models lack the capability to…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Foivos I. Diakogiannis , Suzanne Furby , Peter Caccetta , Xiaoliang Wu , Rodrigo Ibata , Ondrej Hlinka , John Taylor

Multimodality is one of the biggest difficulties for optimization as local optima are often preventing algorithms from making progress. This does not only challenge local strategies that can get stuck. It also hinders meta-heuristics like…

Neural and Evolutionary Computing · Computer Science 2020-10-05 Vera Steinhoff , Pascal Kerschke , Pelin Aspar , Heike Trautmann , Christian Grimme

The definition of a concise and effective testbed for Genetic Programming (GP) is a recurrent matter in the research community. This paper takes a new step in this direction, proposing a different approach to measure the quality of the…

Neural and Evolutionary Computing · Computer Science 2018-05-29 Luiz Otavio Vilas Boas Oliveira , Joao Francisco Barreto da Silva Martins , Luis Fernando Miranda , Gisele Lobo Pappa

Discovering the governing equations of dynamical systems is a central problem across many scientific disciplines. As experimental data become increasingly available, automated equation discovery methods offer a promising data-driven…

Machine Learning · Computer Science 2026-04-07 Amirmohammad Ziaei Bideh , Jonathan Gryak

The last decade has seen the advent and consolidation of ontology based tools for the identification and biological interpretation of classes of genes, such as the Gene Ontology. The information accumulated time-by-time and included in the…

Molecular Networks · Quantitative Biology 2021-08-25 Salvatore Miccichè

In solving multi-modal, multi-objective optimization problems (MMOPs), the objective is not only to find a good representation of the Pareto-optimal front (PF) in the objective space but also to find all equivalent Pareto-optimal subsets…

Neural and Evolutionary Computing · Computer Science 2022-10-24 Tapabrata Ray , Mohammad Mohiuddin Mamun , Hemant Kumar Singh

Large-scale constrained optimization problems are at the core of many tasks in control, signal processing, and machine learning. Notably, problems with functional constraints arise when, beyond a performance{\nobreakdash-}centric goal…

Optimization and Control · Mathematics 2025-05-15 Antesh Upadhyay , Sang Bin Moon , Abolfazl Hashemi

Bayesian optimization (BO) is an efficient and flexible global optimization framework that is applicable to a very wide range of engineering applications. To leverage the capability of the classical BO, many extensions, including…

Machine Learning · Statistics 2021-09-01 Anh Tran , Mike Eldred , Scott McCann , Yan Wang

We describe a unified and coherent syntactic framework for supporting a semantically-informed syntactic approach to statistical machine translation. Semantically enriched syntactic tags assigned to the target-language training texts…

Very recently new genetic operators, called geometric semantic operators, have been defined for genetic programming. Contrarily to standard genetic operators, which are uniquely based on the syntax of the individuals, these new operators…

Neural and Evolutionary Computing · Computer Science 2012-08-14 Mauro Castelli , Luca Manzoni , Leonardo Vanneschi

Recently, increasing attention has been drawn to training semantic segmentation models using synthetic data and computer-generated annotation. However, domain gap remains a major barrier and prevents models learned from synthetic data from…

Computer Vision and Pattern Recognition · Computer Science 2019-01-15 Yuhua Chen , Wen Li , Xiaoran Chen , Luc Van Gool

Semantic shifts can reflect changes in beliefs across hundreds of years, but it is less clear whether trends in fast-changing communities across a short time can be detected. We propose semantic coordinates analysis, a method based on…

Computation and Language · Computer Science 2020-11-03 Zining Zhu , Yang Xu , Frank Rudzicz

Multi-objective optimization (MOO) lies at the core of many machine learning (ML) applications that involve multiple, potentially conflicting objectives (e.g., multi-task learning, multi-objective reinforcement learning, among many others).…

Machine Learning · Computer Science 2024-12-18 Mingjing Xu , Peizhong Ju , Jia Liu , Haibo Yang

Direct Preference Optimization (DPO) is broadly utilized for aligning Large Language Models (LLMs) with human values because of its flexibility. Despite its effectiveness, it has been observed that the capability of DPO to generate…

Machine Learning · Computer Science 2025-05-20 Wenqiao Zhu , Ji Liu , Lulu Wang , Jun Wu , Yulun Zhang

Symbolic Regression (SR) is a regression method that aims to discover mathematical expressions that describe the relationship between variables, and it is often implemented through Genetic Programming, a metaphor for the process of…

Neural and Evolutionary Computing · Computer Science 2025-12-02 Guilherme Seidyo Imai Aldeia

Diverse decoding of large language models is crucial for applications requiring multiple semantically distinct responses, yet existing methods primarily achieve lexical rather than semantic diversity. This limitation significantly…

Computation and Language · Computer Science 2025-09-30 Weijie Shi , Yue Cui , Yaguang Wu , Jingzhi Fang , Shibo Zhang , Mengze Li , Sirui Han , Jia Zhu , Jiajie Xu , Xiaofang Zhou

A significant portion of recent research on Large Language Model (LLM) alignment focuses on developing new policy optimization methods based on Group Relative Policy Optimization (GRPO). Two prominent directions have emerged: (i) a shift…

Machine Learning · Computer Science 2026-02-27 Svetlana Glazyrina , Maksim Kryzhanovskiy , Roman Ischenko