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Whole Slide Images (WSIs) play a crucial role in accurate cancer diagnosis and prognosis, as they provide tissue details at the cellular level. However, the rapid growth of computational tasks involving WSIs poses significant challenges.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Doanh C. Bui , Hoai Luan Pham , Vu Trung Duong Le , Tuan Hai Vu , Van Duy Tran , Khang Nguyen , Yasuhiko Nakashima

Whole slide image (WSI) classification has emerged as a powerful tool in computational pathology, but remains constrained by domain shifts, e.g., due to different organs, diseases, or institution-specific variations. To address this…

Computer Vision and Pattern Recognition · Computer Science 2025-05-14 Pratibha Kumari , Daniel Reisenbüchler , Afshin Bozorgpour , Nadine S. Schaadt , Friedrich Feuerhake , Dorit Merhof

The use of multi-modal data such as the combination of whole slide images (WSIs) and gene expression data for survival analysis can lead to more accurate survival predictions. Previous multi-modal survival models are not able to efficiently…

Computer Vision and Pattern Recognition · Computer Science 2021-12-09 Ruoqi Wang , Ziwang Huang , Haitao Wang , Hejun Wu

Accurate cancer diagnosis remains a critical challenge in digital pathology, largely due to the gigapixel size and complex spatial relationships present in whole slide images. Traditional multiple instance learning (MIL) methods often…

Computer Vision and Pattern Recognition · Computer Science 2024-04-18 Kechun Liu , Wenjun Wu , Joann G. Elmore , Linda G. Shapiro

Multiple Instance Learning is the predominant method for Whole Slide Image classification in digital pathology, enabling the use of slide-level labels to supervise model training. Although MIL eliminates the tedious fine-grained annotation…

Computer Vision and Pattern Recognition · Computer Science 2025-05-28 Chen Shu , Boyu Fu , Yiman Li , Ting Yin , Wenchuan Zhang , Jie Chen , Yuhao Yi , Hong Bu

Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel size and presence of numerous artefacts. Yet they are a valuable resource for patient diagnosis and stratification, often representing the gold…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Amaya Gallagher-Syed , Luca Rossi , Felice Rivellese , Costantino Pitzalis , Myles Lewis , Michael Barnes , Gregory Slabaugh

Histopathology analysis is the gold standard for medical diagnosis. Accurate classification of whole slide images (WSIs) and region-of-interests (ROIs) localization can assist pathologists in diagnosis. The gigapixel resolution of WSI and…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Xitong Ling , Minxi Ouyang , Yizhi Wang , Xinrui Chen , Renao Yan , Hongbo Chu , Junru Cheng , Tian Guan , Sufang Tian , Xiaoping Liu , Yonghong He

Accurate tumor detection in digital pathology whole-slide images (WSIs) is crucial for cancer diagnosis and treatment planning. Multiple Instance Learning (MIL) has emerged as a widely used approach for weakly-supervised tumor detection…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Marina D'Amato , Jeroen van der Laak , Francesco Ciompi

Multiple instance learning (MIL) is a promising approach for weakly supervised classification in pathology using whole slide images (WSIs). However, conventional MIL methods such as Attention-Based Deep Multiple Instance Learning (ABMIL)…

Image and Video Processing · Electrical Eng. & Systems 2025-04-28 Hassan Keshvarikhojasteh , Mihail Tifrea , Sibylle Hess , Josien P. W. Pluim , Mitko Veta

The rapidly emerging field of computational pathology has the potential to enable objective diagnosis, therapeutic response prediction and identification of new morphological features of clinical relevance. However, deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Ming Y. Lu , Drew F. K. Williamson , Tiffany Y. Chen , Richard J. Chen , Matteo Barbieri , Faisal Mahmood

The abundance of information present in Whole Slide Images (WSIs) renders them an essential tool for survival analysis. Several Multiple Instance Learning frameworks proposed for this task utilize a ResNet50 backbone pre-trained on natural…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Kleanthis Marios Papadopoulos , Tania Stathaki

Image-based brain cancer prediction models, based on radiomics, quantify the radiologic phenotype from magnetic resonance imaging (MRI). However, these features are difficult to reproduce because of variability in acquisition and…

Image and Video Processing · Electrical Eng. & Systems 2022-02-07 Xuan Xu , Prateek Prasanna

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

Image and Video Processing · Electrical Eng. & Systems 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

We propose a Hierarchical Multi-scale Knowledge-aware Graph Network (HMKGN) that models multi-scale interactions and spatially hierarchical relationships within whole-slide images (WSIs) for cancer prognostication. Unlike conventional…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Bin Xu , Yufei Zhou , Boling Song , Jingwen Sun , Yang Bian , Cheng Lu , Ye Wu , Jianfei Tu , Xiangxue Wang

Survival prediction using whole-slide images (WSIs) is crucial in cancer re-search. Despite notable success, existing approaches are limited by their reliance on sparse slide-level labels, which hinders the learning of discriminative…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Jiaqi Cui , Lu Wen , Yuchen Fei , Bo Liu , Luping Zhou , Dinggang Shen , Yan Wang

Prognostic information at diagnosis has important implications for cancer treatment and monitoring. Although cancer staging, histopathological assessment, molecular features, and clinical variables can provide useful prognostic insights,…

Whole-slide image (WSI) analysis plays a crucial role in cancer diagnosis and treatment. In addressing the demands of this critical task, self-supervised learning (SSL) methods have emerged as a valuable resource, leveraging their…

Computer Vision and Pattern Recognition · Computer Science 2023-12-13 Gia-Bao Le , Van-Tien Nguyen , Trung-Nghia Le , Minh-Triet Tran

Early diagnosis of lung cancer is a key intervention for the treatment of lung cancer computer aided diagnosis (CAD) can play a crucial role. However, most published CAD methods treat lung cancer diagnosis as a lung nodule classification…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Junhua Chen , Haiyan Zeng , Chong Zhang , Zhenwei Shi , Andre Dekker , Leonard Wee , Inigo Bermejo

Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A. Fallowfield , Hideki Ueno , Hitoshi Tsuda , David J. Harrison , Hakan Bilen , Timothy J. Kendall

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter