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We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic

In this paper, we study novel neural network structures to better model long term dependency in sequential data. We propose to use more memory units to keep track of more preceding states in recurrent neural networks (RNNs), which are all…

Neural and Evolutionary Computing · Computer Science 2016-05-03 Rohollah Soltani , Hui Jiang

Memristor-based Spiking Neural Networks (SNNs) with temporal spike encoding enable ultra-low-energy computation, making them ideal for battery-powered intelligent devices. This paper presents a circuit-level memristive spiking neural…

Emerging Technologies · Computer Science 2025-07-29 Santlal Prajapati , Susmita Sur-Kolay , Soumyadeep Dutta

Motivation: Illumina DNA sequencing is now the predominant source of raw genomic data, and data volumes are growing rapidly. Bioinformatic analysis pipelines are having trouble keeping pace. A common bottleneck in such pipelines is the…

Genomics · Quantitative Biology 2014-09-09 Gregory G. Faust , Ira M. Hall

We present a framework for the design of optimal assembly algorithms for shotgun sequencing under the criterion of complete reconstruction. We derive a lower bound on the read length and the coverage depth required for reconstruction in…

Genomics · Quantitative Biology 2013-02-20 Guy Bresler , Ma'ayan Bresler , David Tse

A space-time adaptive decision feedback (DF) receiver using recurrent neural networks (RNN) is proposed for joint equalization and interference suppression in direct-sequence code-division-multiple-access (DS-CDMA) systems equipped with…

Information Theory · Computer Science 2013-01-23 Rodrigo C. de Lamare , Raimundo Sampaio-Neto

Given a pedestrian image as a query, the purpose of person re-identification is to identify the correct match from a large collection of gallery images depicting the same person captured by disjoint camera views. The critical challenge is…

Computer Vision and Pattern Recognition · Computer Science 2017-12-05 Lin Wu , Yang Wang

RNA sequencing (RNA-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing. Current RNA-seq protocols depend on high-throughput…

Genomics · Quantitative Biology 2015-06-19 Hyunghoon Cho , Joe Davis , Xin Li , Kevin S. Smith , Alexis Battle , Stephen B. Montgomery

This paper presents a new approach to statistical similarity assessment based on sequence alignment. The algorithm performs mutual matching of two random sequences by successively searching for common elements and by applying sequence…

Signal Processing · Electrical Eng. & Systems 2021-06-09 Jakub Nikonowicz , Łukasz Matuszewski , Paweł Kubczak

Training deep recurrent neural network (RNN) architectures is complicated due to the increased network complexity. This disrupts the learning of higher order abstracts using deep RNN. In case of feed-forward networks training deep…

Computation and Language · Computer Science 2018-08-07 Murali Karthick Baskar , Martin Karafiat , Lukas Burget , Karel Vesely , Frantisek Grezl , Jan Honza Cernocky

Sequence classification is essential in NLP for understanding and categorizing language patterns in tasks like sentiment analysis, intent detection, and topic classification. Transformer-based models, despite achieving state-of-the-art…

Computation and Language · Computer Science 2025-09-30 Hongbo Liu , Jia Xu

In this work we implement the so-called matching time estimators for estimating the entropy rate as well as the entropy production rate for symbolic sequences. These estimators are based on recurrence properties of the system, which have…

Information Theory · Computer Science 2022-01-12 R. Salgado-García

Recurrent neural networks (RNNs) have been applied to a broad range of applications, including natural language processing, drug discovery, and video recognition. Their vulnerability to input perturbation is also known. Aligning with a view…

Machine Learning · Computer Science 2021-05-14 Wei Huang , Youcheng Sun , Xingyu Zhao , James Sharp , Wenjie Ruan , Jie Meng , Xiaowei Huang

Sequencing a DNA strand, as part of the read process in DNA storage, produces multiple noisy copies which can be combined to produce better estimates of the original strand; this is called trace reconstruction. One can reduce the error rate…

Information Theory · Computer Science 2024-08-22 Sundara Rajan Srinivasavaradhan , Sivakanth Gopi , Henry D. Pfister , Sergey Yekhanin

We introduce a novel approach to reduce the number of times required for reprogramming memristors on bit-sliced compute-in-memory crossbars for deep neural networks (DNNs). Our idea addresses the limited non-volatile memory endurance, which…

Hardware Architecture · Computer Science 2025-07-10 Matheus Farias , H. T. Kung

Recurrent Neural Network (RNN) and one of its specific architectures, Long Short-Term Memory (LSTM), have been widely used for sequence labeling. In this paper, we first enhance LSTM-based sequence labeling to explicitly model label…

Computation and Language · Computer Science 2016-09-01 Gakuto Kurata , Bing Xiang , Bowen Zhou , Mo Yu

Summary: BWA-MEM is a new alignment algorithm for aligning sequence reads or long query sequences against a large reference genome such as human. It automatically chooses between local and end-to-end alignments, supports paired-end reads…

Genomics · Quantitative Biology 2013-05-28 Heng Li

Memristor-based neuromorphic computing could overcome the limitations of traditional von Neumann computing architectures -- in which data are shuffled between separate memory and processing units -- and improve the performance of deep…

In a DNA sequence, we have the celebrated Watson-Crick complement $\overline{T}=A$, $\overline{A}=T$, $\overline{C}=G$, and $\overline{G}=C$. Given an integer $m\ge 2$, a secondary structure in a DNA sequence refers to the existence of two…

Information Theory · Computer Science 2023-04-25 Hui Chu , Chen Wang , Yiwei Zhang

Motivation: Despite significant advances in Third-Generation Sequencing (TGS) technologies, Next-Generation Sequencing (NGS) technologies remain dominant in the current sequencing market. This is due to the lower error rates and richer…

Information Theory · Computer Science 2023-04-04 Jia Wang , Yi Niu , Tianyi Xu , Mingming Ma , Dahua Gao , Guangming Shi
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