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Identifying the mutations that drive cancer growth is key in clinical decision making and precision oncology. As driver mutations confer selective advantage and thus have an increased likelihood of occurrence, frequency-based statistical…

Genomics · Quantitative Biology 2021-05-04 Adnan Akbar , Andrey Solovyev , John W Cassidy , Nirmesh Patel , Harry W Clifford

Mycetoma is a chronic and neglected inflammatory disease prevalent in tropical and subtropical regions. It can lead to severe disability and social stigma. The disease is classified into two types based on the causative microorganisms:…

Image and Video Processing · Electrical Eng. & Systems 2024-10-18 Hyam Omar Ali , Romain Abraham , Guillaume Desoubeaux , Ahmed Fahal , Clovis Tauber

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

Quantitative Methods · Quantitative Biology 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

Foundation large language models (LLMs) have shown an impressive ability to solve tasks across a wide range of fields including health. To effectively solve personalized health tasks, LLMs need the ability to ingest a diversity of data…

The rise of Antimicrobial Resistance, particularly Multi-Drug Resistance (MDR), presents a critical challenge for clinical decision-making due to limited treatment options and delays in conventional susceptibility testing. This study…

Machine Learning · Computer Science 2026-03-03 Santanam Wishal , Riad Sahara

The intricate relationship between genetic variation and human diseases has been a focal point of medical research, evidenced by the identification of risk genes regarding specific diseases. The advent of advanced genome sequencing…

Quantitative Methods · Quantitative Biology 2024-01-19 Jiayu Chang , Shiyu Wang , Chen Ling , Zhaohui Qin , Liang Zhao

Machine learning systems trained on electronic health records (EHRs) increasingly guide treatment decisions, but their reliability depends on the critical assumption that patients follow the prescribed treatments recorded in EHRs. Using EHR…

Machine Learning · Computer Science 2025-04-22 Zhongyuan Liang , Arvind Suresh , Irene Y. Chen

Leukemia, the cancer of blood cells, originates in the blood-forming cells of the bone marrow. In Chronic Myeloid Leukemia (CML) conditions, the cells partially become mature that look like normal white blood cells but do not resist…

Genomics · Quantitative Biology 2023-02-09 Madiha Hameed , Muhammad Bilal , Tuba Majid , Abdul Majid , Asifullah Khan

Longitudinal omics data (LOD) analysis is essential for understanding the dynamics of biological processes and disease progression over time. This review explores various statistical and computational approaches for analyzing such data,…

Methodology · Statistics 2025-06-16 Ali R. Taheriyoun , Allen Ross , Abolfazl Safikhani , Damoon Soudbakhsh , Ali Rahnavard

Healthcare datasets present many challenges to both machine learning and statistics as their data are typically heterogeneous, censored, high-dimensional and have missing information. Feature selection is often used to identify the…

Machine Learning · Computer Science 2022-07-06 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Estimating how a treatment affects units individually, known as heterogeneous treatment effect (HTE) estimation, is an essential part of decision-making and policy implementation. The accumulation of large amounts of data in many domains,…

Machine Learning · Computer Science 2022-06-28 Christopher Tran , Elena Zheleva

AI algorithms have become valuable in aiding professionals in healthcare. The increasing confidence obtained by these models is helpful in critical decision demands. In clinical dermatology, classification models can detect malignant…

To enable personalized cancer treatment, machine learning models have been developed to predict drug response as a function of tumor and drug features. However, most algorithm development efforts have relied on cross validation within a…

Rheumatoid arthritis (RA) is an autoimmune condition caused when patients' immune system mistakenly targets their own tissue. Machine learning (ML) has the potential to identify patterns in patient electronic health records (EHR) to…

Quantitative Methods · Quantitative Biology 2022-10-25 Shengjia Chen , Nikunj Gupta , Woodward B. Galbraith , Valay Shah , Jacopo Cirrone

This paper evaluates various deep learning methods for measurable residual disease (MRD) detection in flow cytometry (FCM) data, addressing questions regarding the benefits of modeling long-range dependencies, methods of obtaining global…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Lisa Weijler , Michael Reiter , Pedro Hermosilla , Margarita Maurer-Granofszky , Michael Dworzak

We present an outline of the first large language model (LLM) based chatbot application in the context of patient-reported outcome measures (PROMs) for diabetic retinopathy. By utilizing the capabilities of current LLMs, we enable patients…

Computation and Language · Computer Science 2024-11-06 Maren Pielka , Tobias Schneider , Jan Terheyden , Rafet Sifa

Anonymized electronic medical records are an increasingly popular source of research data. However, these datasets often lack race and ethnicity information. This creates problems for researchers modeling human disease, as race and…

Quantitative Methods · Quantitative Biology 2018-05-01 Ji-Sung Kim , Xin Gao , Andrey Rzhetsky

Gliomas are lethal type of central nervous system tumors with a poor prognosis. Recently, with the advancements in the micro-array technologies thousands of gene expression related data of glioma patients are acquired, leading for salient…

Genomics · Quantitative Biology 2020-11-03 Navodini Wijethilake , Dulani Meedeniya , Charith Chitraranjan , Indika Perera

Glaucoma is a major eye disease, leading to vision loss in the absence of proper medical treatment. Current diagnosis of glaucoma is performed by ophthalmologists who are often analyzing several types of medical images generated by…

Computer Vision and Pattern Recognition · Computer Science 2019-04-05 Mijung Kim , Olivier Janssens , Ho-min Park , Jasper Zuallaert , Sofie Van Hoecke , Wesley De Neve

Background: Parkinson's disease remains a major neurodegenerative disorder with high misdiagnosis rates, primarily due to reliance on clinical rating scales. Recent studies have demonstrated a strong association between gut microbiota and…

Artificial Intelligence · Computer Science 2025-09-10 Bo Yu , Zhixiu Hua , Bo Zhao