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Fibrous networks are ideal functional materials since they provide mechanical rigidity at low weight. Such structures are omnipresent in natural biomaterials from cells to tissues, as well as in man-made materials from polymeric composites…

Many biological processes involve the action of molecular motors that interact with the cell cytoskeleton. Some processes, such as the transport of cargoes is achieved mainly by the action of individual motors. Other, such as cell motility…

Biological Physics · Physics 2011-03-25 Oded Farago , Anne Bernheim-Groswasser

Mesh-like structures, such as mucus gel or cytoskeleton networks, are ubiquitous in biological systems. These intricate structures are composed of cross-linked, semi-flexible bio-filaments, crucial to numerous biological processes. In many…

Soft Condensed Matter · Physics 2024-01-10 Yeongjin Kim , Won Kyu Kim , Jae-Hyung Jeon

Living systems often exhibit internal driving: active, molecular processes drive nonequilibrium phenomena such as metabolism or migration. Active gels constitute a fascinating class of internally driven matter, where molecular motors exert…

Biological Physics · Physics 2015-06-15 Jose Alvarado , Michael Sheinman , Abhinav Sharma , Fred C. MacKintosh , Gijsje H. Koenderink

Network science can offer fundamental insights into the structural and functional properties of complex systems. For example, it is widely known that neuronal circuits tend to organize into basic functional topological modules, called…

Adaptation and Self-Organizing Systems · Physics 2022-08-03 Matteo Zambra , Alberto Testolin , Amos Maritan

We review the physical properties of macromolecular networks, consisting of semiflexible polymers such as actin. We start by giving a theoretical analysis of the conformational statistics and mechanical response of single filaments.…

Soft Condensed Matter · Physics 2008-02-03 Erwin Frey , Klaus Kroy , Jan Wilhelm , Erich Sackmann

In complex systems, groups of interacting objects may form prevalent and persistent spatiotemporal patterns, which we refer to as motifs. These motifs can exhibit features that reveal how individual objects interact with one another.…

Biological Physics · Physics 2025-12-12 Ying Chen Lim , Rakesh Das , Tetsuya Hiraiwa , N. Duane Loh

Intermediate filaments form an essential structural network, spread throughout the cytoplasm and play a key role in cell mechanics, intracellular organization and molecular signaling. The maintenance of the network and its adaptation to the…

Subcellular Processes · Quantitative Biology 2023-06-14 Youngmin Park , Cécile Leduc , Sandrine Etienne-Manneville , Stéphanie Portet

Twisted and rope-like assemblies of filamentous molecules are common and vital structural elements in cells and tissue of living organisms. We study the intrinsic frustration occurring in these materials between the two-dimensional…

Soft Condensed Matter · Physics 2015-06-03 Amir Azadi , Gregory M. Grason

In biological systems, molecular-scale forces and motions are pivotal for enabling processes like motility, shape change, and replication. These forces and motions are organized, amplified, and transmitted across macroscopic scales by…

The formation of bundles composed of actin filaments and cross-linking proteins is an essential process in the maintenance of the cells' cytoskeleton. It has also been recreated by in-vitro experiments, where actin networks are routinely…

Soft Condensed Matter · Physics 2009-11-13 Nir S. Gov

Diverse polymer crosslinking techniques allow the synthesis of linear polymer-like structures whose monomers are colloidal particles. In the case where all or part of these colloidal particles are magnetic, one can control the behaviour of…

Soft Condensed Matter · Physics 2020-03-18 Deniz Mostarac , Leo Vaughan , Pedro A. Sánchez , Sofia S. Kantorovich

Multiplex networks describe a large number of systems ranging from social networks to the brain. These multilayer structure encode information in their structure. This information can be extracted by measuring the correlations present in…

Disordered Systems and Neural Networks · Physics 2015-04-23 Giulia Menichetti , Daniel Remondini , Ginestra Bianconi

Living cells move thanks to assemblies of actin filaments and myosin motors that range from very organized striated muscle tissue to disordered intracellular bundles. The mechanisms powering these disordered structures are debated, and all…

Biological Physics · Physics 2017-09-26 Martin Lenz

Mixtures of particles that interact through phoretic effects are known to aggregate if they belong to species that exhibit attractive self-interactions. We study self-organization in a model metabolic cycle composed of three species of…

Soft Condensed Matter · Physics 2023-09-29 Vincent Ouazan-Reboul , Ramin Golestanian , Jaime Agudo-Canalejo

Here, the general design and properties of new multiple network elastomers with an exceptional combination of stiffness, toughness, and elasticity are reported. In this paper, it is reported in more detail how the increase in strain at…

Soft Condensed Matter · Physics 2017-02-14 Etienne Ducrot , Costantino Creton

Motivated by recent experiments showing that stiff biopolymer gels exhibit highly unusual negative normal elastic stresses, we develop a computational model for stiff polymer networks subject to large strains. In all cases, we find that…

Soft Condensed Matter · Physics 2009-11-13 Enrico Conti , F. C. MacKintosh

At the heart of the structured architecture and complex dynamics of biological systems are specific and timely interactions operated by biomolecules. In many instances, biomolecular agents are spatially confined to flexible lipid membranes…

Soft Condensed Matter · Physics 2020-01-08 Bortolo Mognetti , Pietro Cicuta , Lorenzo Di Michele

Biopolymer networks are common in biological systems from the cytoskeleton of individual cells to collagen in the extracellular matrix. The mechanics of these systems under applied strain can be explained in some cases by a phase transition…

Soft Condensed Matter · Physics 2022-12-21 Sadjad Arzash , Abhinav Sharma , Fred C. MacKintosh

A cell's behavior is a consequence of the complex interactions between its numerous constituents, such as DNA, RNA, proteins and small molecules. Cells use signaling pathways and regulatory mechanisms to coordinate multiple processes,…

Molecular Networks · Quantitative Biology 2007-09-12 Reka Albert