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Providing architectural support is crucial for newly arising applications to achieve high performance and high system efficiency. Currently there is a trend in designing accelerators for special applications, while arguably a debate is…
The rise of data-intensive applications exposed the limitations of conventional processor-centric von-Neumann architectures that struggle to meet the off-chip memory bandwidth demand. Therefore, recent innovations in computer architecture…
Kernel matrices (e.g. Gram or similarity matrices) are essential for many state-of-the-art approaches to classification, clustering, and dimensionality reduction. For large datasets, the cost of forming and factoring such kernel matrices…
Reducing the cost of sequencing genomes provided by next-generation sequencing technologies has greatly increased the number of genomic projects. As a result, there is a growing need for better assembly and assembly validation methods. One…
Next-generation sequencing (NGS) technologies have enabled affordable sequencing of billions of short DNA fragments at high throughput, paving the way for population-scale genomics. Genomics data analytics at this scale requires overcoming…
The continually increasing volume of DNA sequence data has resulted in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments between candidate haplotypes and sequencing reads using Pair-HMMs is a…
In recent years, the rapidly increasing number of reads produced by next-generation sequencing (NGS) technologies has driven the demand for efficient implementations of sequence alignments in bioinformatics. However, current…
Deep Learning Recommendation Model(DLRM)s utilize the embedding layer to represent various categorical features. Traditional DLRMs adopt unified embedding size for all features, leading to suboptimal performance and redundant parameters.…
Generative Large Language Models (LLMs) have demonstrated remarkable results for a wide range of tasks. However, deploying these models for inference has been a significant challenge due to their unprecedented resource requirements. This…
Long-context DNA models are limited by token-mixing cost and by how compression allocates representational budget across the genome. Existing approaches operate close to base-pair resolution, apply fixed downsampling, or learn…
The surge in availability of genomic data holds promise for enabling determination of genetic causes of observed individual traits, with applications to problems such as discovery of the genetic roots of phenotypes, be they molecular…
Approximate Nearest Neighbor Search (ANNS) is a cornerstone algorithm for information retrieval, recommendation systems, and machine learning applications. While x86-based architectures have historically dominated this domain, the…
A novel generative site-specific beamforming (GenSSBF) approach, termed fast beam-brainstorm (F-BBS), is proposed to address the practical bottlenecks of slow beam generation and fixed channel probing lengths in existing GenSSBF. To…
Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current analysis methods often struggle with…
Genome assembly from the high-throughput sequencing (HTS) reads is a fundamental yet challenging computational problem. An intrinsic challenge is the uncertainty caused by the widespread repetitive elements. Here we get around the…
Pseudo-heterodyne scattering-type scanning near-field optical microscopy (sSNOM) is applied in the mid-infrared region to detect the chemical composition of biomolecules on the nanoscale. However, the application of sSNOM in molecular…
Subgraph matching has garnered increasing attention for its diverse real-world applications. Given the dynamic nature of real-world graphs, addressing evolving scenarios without incurring prohibitive overheads has been a focus of research.…
To address the challenge of increasing network size, researchers have developed sparse models through network pruning. However, maintaining model accuracy while achieving significant speedups on general computing devices remains an open…
While Large Language Models (LLMs) have achieved remarkable success in various fields, the efficiency of training and inference remains a major challenge. To address this issue, we propose SUBLLM, short for Subsampling-Upsampling-Bypass…
Self-Attention Mechanism (SAM) is good at capturing the internal connections of features and greatly improves the performance of machine learning models, espeacially requiring efficient characterization and feature extraction of…