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External controls (ECs) from historical trials or real-world data have gained increasing attention as a way to augment hybrid and single-arm trials, especially when balanced randomization is infeasible. While most existing work has focused…

Methodology · Statistics 2025-12-15 Yujing Gao , Xiang Zhang , Shu Yang

Online controlled experiments are the primary tool for measuring the causal impact of product changes in digital businesses. It is increasingly common for digital products and services to interact with customers in a personalised way. Using…

Methodology · Statistics 2021-07-02 C. H. Bryan Liu , Benjamin Paul Chamberlain

In cancer research, leveraging patient-derived xenografts (PDXs) in pre-clinical experiments is a crucial approach for assessing innovative therapeutic strategies. Addressing the inherent variability in treatment response among and within…

The traditional user-centered design process can hardly keep up with the ever faster technical development and increasingly diverse user preferences. As a solution, we propose to augment the tried-and-tested approach of conducting user…

Human-Computer Interaction · Computer Science 2023-02-23 Florian Fischer , Arthur Fleig , Markus Klar , Viktorija Paneva , Jörg Müller

We present GRACE, a simulation-native agent for autonomous experimental design in high-energy and nuclear physics. Given multimodal input in the form of a natural-language prompt or a published experimental paper, the agent extracts a…

High Energy Physics - Experiment · Physics 2026-02-18 Justin Hill , Hong Joo Ryoo

Interactive systems are commonly prototyped as web applications. This approach enables studies with functional prototypes on a large scale. However, setting up these studies can be complex due to implementing experiment procedures,…

Human-Computer Interaction · Computer Science 2025-05-20 Florian Lehmann , Daniel Buschek

Designing and evaluating personalized and proactive assistant agents remains challenging due to the time, cost, and ethical concerns associated with human-in-the-loop experimentation. Existing Human-Computer Interaction (HCI) methods often…

Human-Computer Interaction · Computer Science 2025-11-25 Ziyi Xuan , Yiwen Wu , Xuhai Xu , Vinod Namboodiri , Mooi Choo Chuah , Yu Yang

Statistical power estimation for studies with multiple model parameters is inherently a multivariate problem. Power for individual parameters of interest cannot be reliably estimated univariately since correlation and variance explained…

Methodology · Statistics 2022-05-25 Ajinkya K Mulay , Sean Lane , Erin Hennes

Often user interfaces of theorem proving systems focus on assisting particularly trained and skilled users, i.e., proof experts. As a result, the systems are difficult to use for non-expert users. This paper describes a paper and pencil HCI…

Artificial Intelligence · Computer Science 2009-03-24 Martin Homik , Andreas Meier

In each of the last five years, a few dozen empirical studies appeared in visualization journals and conferences. The existing empirical studies have already featured a large number of variables. There are many more variables yet to be…

Human-Computer Interaction · Computer Science 2020-09-29 Min Chen , Alfie Abdul-Rahman , David H. Laidlaw

Healthcare companies must submit pharmaceutical drugs or medical devices to regulatory bodies before marketing new technology. Regulatory bodies frequently require transparent and interpretable computational modelling to justify a new…

Applications · Statistics 2019-01-15 Simon Olofsson , Marc Peter Deisenroth , Ruth Misener

Despite its importance to experimental design, statistical power (the probability that, given a real effect, an experiment will reject the null hypothesis) has largely been ignored by the NLP community. Underpowered experiments make it more…

Computation and Language · Computer Science 2020-10-15 Dallas Card , Peter Henderson , Urvashi Khandelwal , Robin Jia , Kyle Mahowald , Dan Jurafsky

A key challenge in science and engineering is to design experiments to learn about some unknown quantity of interest. Classical experimental design optimally allocates the experimental budget to maximize a notion of utility (e.g., reduction…

Machine Learning · Computer Science 2022-11-10 Mojmír Mutný , Tadeusz Janik , Andreas Krause

At every phase of scientific research, scientists must decide how to allocate limited resources to pursue the research inquiries with the greatest potential. This prioritization dictates which controlled interventions are studied, awarded…

Methodology · Statistics 2022-10-11 Bruce A. Corliss , Yaotian Wang , Heman Shakeri , Philip E. Bourne

Evaluating UX in the context of AI's complexity, unpredictability, and generative nature presents unique challenges. How can we support HCI researchers to create comprehensive UX evaluation plans? In this paper, we introduce EvAlignUX, a…

Human-Computer Interaction · Computer Science 2025-07-09 Qingxiao Zheng , Minrui Chen , Pranav Sharma , Yiliu Tang , Mehul Oswal , Yiren Liu , Yun Huang

Mediation analyses are a statistical tool for testing the hypothesis about how the relationship between two variables may be direct or indirect via a third variable. Assessing statistical significance has been an area of active research;…

Methodology · Statistics 2021-06-07 Jason Steffener

The Learn-As-you-GO (LAGO) design provides a rigorous framework for adapting the intervention package based on accumulating data while the trial is ongoing. This article improves the flexibility of the LAGO design by incorporating…

Methodology · Statistics 2025-09-16 Ante Bing , Donna Spiegelman , Judith J. Lok

We develop an empirical Bayes framework for experimental design that leverages information from prior related studies. When a researcher has access to estimates from previous studies on similar parameters, they can use empirical Bayes to…

Econometrics · Economics 2026-02-25 Zhiheng You

To date, power electronics parameter design tasks are usually tackled using detailed optimization approaches with detailed simulations or using brute force grid search grid search with very fast simulations. A new method, named…

Machine Learning · Computer Science 2023-10-17 Dominik Happel , Philipp Brendel , Andreas Rosskopf , Stefan Ditze

Simulating trajectories of virtual crowds is a commonly encountered task in Computer Graphics. Several recent works have applied Reinforcement Learning methods to animate virtual agents, however they often make different design choices when…

Machine Learning · Computer Science 2022-09-21 Ariel Kwiatkowski , Vicky Kalogeiton , Julien Pettré , Marie-Paule Cani