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Molecular dynamics facilitates the simulation of a complex system to be analyzed at molecular and atomic levels. Simulations can last a long period of time, even months. Due to this cause the graphics processing units (GPUs) and multi-core…

Computational Physics · Physics 2021-02-02 Iuliana Marin , Nicolae Goga , Maria Goga

We describe collective-move Monte Carlo algorithms designed to approximate the overdamped dynamics of self-assembling nanoscale components equipped with strong, short-ranged and anisotropic interactions. Conventional Monte Carlo simulations…

Statistical Mechanics · Physics 2012-04-16 Stephen Whitelam

Molecular dynamics simulations provide a mechanistic description of molecules by relying on empirical potentials. The quality and transferability of such potentials can be improved leveraging data-driven models derived with machine learning…

We present a minimal model for simulating dynamics of assorted lipid assemblies in a computationally efficient manner. Our model is particle-based and consists of coarse-grained beads put together on a modular platform to give generic…

Chemical Physics · Physics 2019-10-15 John M. A. Grime , Jesper J. Madsen

Machine learning potentials have emerged as a means to enhance the accuracy of biomolecular simulations. However, their application is constrained by the significant computational cost arising from the vast number of parameters compared to…

Molecular Dynamics (MD) codes predict the fundamental properties of matter by following the trajectories of a collection of interacting model particles. To exploit diverse modern manycore hardware, efficient codes must use all available…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-08-04 William R. Saunders , James Grant , Eike H. Müller

TinyML is a fast-growing multidisciplinary field at the intersection of machine learning, hardware, and software, that focuses on enabling deep learning algorithms on embedded (microcontroller powered) devices operating at extremely low…

Machine Learning · Computer Science 2021-02-03 Stanislava Soro

Molecular dynamics (MD) simulations can model the interactions between macromolecules with high spatiotemporal resolution but at a high computational cost. By combining high-throughput MD with Markov state models (MSMs), it is now possible…

Chemical Physics · Physics 2018-06-13 Manuel Dibak , Mauricio J. del Razo , David De Sancho , Christof Schütte , Frank Noé

Tiny Machine Learning (TinyML) algorithms have seen extensive use in recent years, enabling wearable devices to be not only connected but also genuinely intelligent by running machine learning (ML) computations directly on-device. Among…

Machine Learning · Computer Science 2025-11-21 Massimo Pavan , Claudio Galimberti , Manuel Roveri

Simulations of biological macromolecules play an important role in understanding the physical basis of a number of complex processes such as protein folding. Even with increasing computational power and evolution of specialized…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-09-18 Hyungro Lee , Heng Ma , Matteo Turilli , Debsindhu Bhowmik , Shantenu Jha , Arvind Ramanathan

Warm dense matter systems created in the laboratory are highly dynamical. In such cases electron dynamics is often needed to accurately simulate the evolution and properties of the system. Large systems force one to make simple…

Quantum Gases · Physics 2014-08-13 Paul E. Grabowski

Molecular Dynamics (MD) simulations are essential for understanding the atomic-level behavior of molecular systems, giving insights into their transitions and interactions. However, classical MD techniques are limited by the trade-off…

Biomolecules · Quantitative Biology 2026-04-21 Ziyang Yu , Wenbing Huang , Yang Liu

A new pairwise hybrid machine-learning/molecular mechanics (ML/MM) potential is introduced that is conceived for application to large, heterogeneous condensed-phase systems. The PhysNet ML method describes monomers and short-range dimer…

Chemical Physics · Physics 2026-03-17 Kham Lek Chaton , Eric D. Boittier , Mike Devereux , Markus Meuwly

Proxy-apps, or mini-apps, are simple self-contained benchmark codes with performance-relevant kernels extracted from real applications. Initially used to facilitate software-hardware co-design, they are a crucial ingredient for serious…

Computational Physics · Physics 2022-07-28 Rafael Ravedutti Lucio Machado , Jan Eitzinger , Harald Köstler , Gerhard Wellein

Particle-wall interactions play a crucially important role in various applications such as microfluidic devices for cell sorting, particle separation, entire class of hydrodynamic filtration and its derivatives, etc. Yet, accurate…

Fluid Dynamics · Physics 2025-03-18 Aryan Mehboudi , Shrawan Singhal , S. V. Sreenivasan

Language models have gained significant interest due to their general-purpose capabilities, which appear to emerge as models are scaled to increasingly larger parameter sizes. However, these large models impose stringent requirements on…

Machine Learning · Computer Science 2024-12-23 Savitha Viswanadh Kandala , Pramuka Medaranga , Ambuj Varshney

Design of robots at the small scale is a trial-and-error based process, which is costly and time-consuming. There are no good dynamic simulation tools to predict the motion or performance of a microrobot as it moves against a substrate. At…

Robotics · Computer Science 2019-07-31 Jiayin Xie , Chenghao Bi , David J. Cappelleri , Nilanjan Chakraborty

Recent developments, both in theoretical modeling and computational power, have allowed us to make progress on a goal not fully achieved yet in nuclear theory: a microscopic theory of nuclear fission. Even if the complete microscopic…

Nuclear Theory · Physics 2022-03-29 I. Stetcu , A. Bulgac , S. Jin , K. J. Roche , N. Schunck

We introduce a natively distributed mini-application benchmark representative of plastic spiking neural network simulators. It can be used to measure performances of existing computing platforms and to drive the development of future…

MiMiC is a flexible and efficient framework for multiscale simulations in which different subsystems are treated by individual client programs. In this work, we present a new interface with OpenMM to be used as an MM client program and we…

Chemical Physics · Physics 2025-02-11 Andrea Levy , Andrej Antalík , Jógvan Magnus Haugaard Olsen , Ursula Rothlisberger