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Molecular dynamics simulations have revealed a dramatic increase, with increasing temperature, of the amplitude of electrostatic fluctuations caused by water at the active site of metalloprotein plastocyanin. The increased breadth of…

Biological Physics · Physics 2009-11-13 David N. LeBard , Dmitry V. Matyushov

We consider two types of fluctuations in the mass-action equilibrium in protein binding networks. The first type is driven by relatively slow changes in total concentrations (copy numbers) of interacting proteins. The second type, to which…

Molecular Networks · Quantitative Biology 2009-11-13 Koon-Kiu Yan , Dylan Walker , Sergei Maslov

Using analytical calculations and computer simulations we consider both the lateral diffusion of a membrane protein and the fluctuation spectrum of the membrane in which the protein is embedded. The membrane protein interacts with the…

Soft Condensed Matter · Physics 2015-05-18 Ellen Reister-Gottfried , Stefan M. Leitenberger , Udo Seifert

We study a gas of hard rods on a ring, driven by an external thermostat, with either elastic or inelastic collisions, which exhibits sub-diffusive behavior $<x^2 > \sim t^{1/2}$. We show the validity of the usual Fluctuation-Dissipation…

Statistical Mechanics · Physics 2008-10-10 D. Villamaina , A. Puglisi , A. Vulpiani

Vitrification during cryopreservation requires a detailed understanding of the dynamic behavior of biological solutions. We investigate ferritin diffusion in glycerol-water mixtures at supercooled temperatures using X-ray Photon Correlation…

The observed variability of X-ray binaries over a wide range of time-scales can be understood in the framework of a stochastic propagation model, where viscous fluctuations at different radii induce accretion rate variability that propagate…

High Energy Astrophysical Phenomena · Physics 2017-08-18 Naveel Ahmad , Ranjeev Misra , Naseer Iqbal , Bari Maqbool , Mubashir Hamid

We discuss the emergence and growth of the cooperativity accompanying vitrification based on the density fluctuation dynamics for fragile glass-forming liquids. (i) The relaxation of density fluctuations proceeds by the particle (density)…

Soft Condensed Matter · Physics 2019-11-11 Akira Furukawa

We study the fluctuations in equilibrium for a dynamics of rods with random length. This includes the classical hard rod elastic collisions, when rod lengths are constant and equal to a positive value. We prove that in the diffusive…

Mathematical Physics · Physics 2024-11-20 Pablo A. Ferrari , Stefano Olla

Hydrodynamic interactions are important for diverse fluids especially those with low Reynold's number such as microbial and particle-laden suspensions, and proteins diffusing in membranes. Unfortunately, while far-field (asymptotic)…

Soft Condensed Matter · Physics 2023-02-10 Noman Hanif Barbhuiya , A. G. Yodh , Chandan K. Mishra

Localization properties of residue fluctuations in globular proteins are studied theoretically by using the Gaussian network model. Participation ratio for each residue fluctuation mode is calculated. It is found that the relationship…

Biological Physics · Physics 2009-11-10 Yinhao Wu , Xianzhang Yuan , Xia Gao , Haiping Fang , Jian Zi

Protein dynamics is a fundamental element to comprehend their biological functions. However, a theoretical picture providing microscopic-detail explanation of its relevant features is still missing. One of the outmost relevant properties…

Soft Condensed Matter · Physics 2023-06-14 Luca Maggi

We investigate dynamical coupling between water and amino acid side-chain residues in solvation dynamics by selecting residues often used as natural probes, namely tryptophan, tyrosine and histidine, located at different positions on…

Biomolecules · Quantitative Biology 2017-08-04 Sayantan Mondal , Saumyak Mukherjee , Biman Bagchi

We develop stochastic mixed finite element methods for spatially adaptive simulations of fluid-structure interactions when subject to thermal fluctuations. To account for thermal fluctuations, we introduce a discrete fluctuation-dissipation…

Mesoscale and Nanoscale Physics · Physics 2023-02-28 Pat Plunkett , Jon Hu , Chris Siefert , Paul J. Atzberger

Structure fluctuations and conformational changes accompany all biological processes involving macromolecules. The paper presents a classification of protein residues based on the normalized equilibrium fluctuations of the residue centers…

Biological Physics · Physics 2015-05-30 Anatoly M. Ruvinsky , Tatsiana Kirys , Alexander V. Tuzikov , Ilya A. Vakser

Across a large range of scales, accreting sources show remarkably similar patterns of variability, most notably the log-normality of the luminosity distribution and the linear root-mean square (rms)-flux relationship. These results are…

High Energy Astrophysical Phenomena · Physics 2024-01-30 Samuel G. D. Turner , Christopher S. Reynolds

We analyze the behavior of an ensemble of inertial particles in a one-dimensional smooth Gaussian velocity field, in the limit of large inertia, but considering a finite correlation time for the random field. We derive in this limit a…

Statistical Mechanics · Physics 2009-11-13 Piero Olla , Raffaella Vuolo

A model for diffusion in liquids that couples the dynamics of tracer particles to a fluctuating Stokes equation for the fluid is investigated in the limit of large Schmidt number. In this limit, the concentration of tracers is shown to…

Statistical Mechanics · Physics 2014-04-03 A. Donev , T. G. Fai , and E. Vanden-Eijnden

A new statistical mechanics formulation of characterizing the structural fluctuation of protein correlated with that of water is presented based on the generalized Langevin equation and the 3D-RISM/RISM theory of molecular liquids. The…

Statistical Mechanics · Physics 2015-06-11 Bongsoo Kim , Fumio Hirata

A formal analogy of fluctuating diffusivity to thermodynamics is discussed for messenger RNA molecules fluorescently fused to a protein in living cells. Regarding the average value of the fluctuating diffusivity of such RNA-protein…

Statistical Mechanics · Physics 2021-03-17 Yuichi Itto

The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics. We show here that protein distributions measured under a broad range of…

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