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New computational strategies, such as molecular docking, are emerging to speed up the drug discovery process. This method predicts the activity of molecules at the binding site of proteins, helping to select the ones that exhibit desirable…

Quantum Physics · Physics 2024-02-13 Mathieu Garrigues , Victor Onofre , Noé Bosc-Haddad

Quantum annealing approximately solves combinatorial optimization problems by leveraging the principles of adiabatic quantum systems. In this approach, the system's Hamiltonian evolves from an initial general state to a problem-specific…

The quantum approximate optimization algorithm (QAOA) has the potential to approximately solve complex combinatorial optimization problems in polynomial time. However, current noisy quantum devices cannot solve large problems due to…

Quantum machines are among the most promising technologies expected to provide significant improvements in the following years. However, bridging the gap between real-world applications and their implementation on quantum hardware is still…

Quantum annealers have grown in complexity to the point that quantum computations involving few thousands of qubits are now possible. In this paper, \textcolor{black}{with the intentions to show the feasibility of quantum annealing to…

Materials Science · Physics 2020-12-30 Virginia Carnevali , Ilaria Siloi , Rosa Di Felice , Marco Fornari

In this work, we explore graph partitioning (GP) using quantum annealing on the D-Wave 2X machine. Motivated by a recently proposed graph-based electronic structure theory applied to quantum molecular dynamics (QMD) simulations, graph…

Quantum Physics · Physics 2017-05-10 Hayato Ushijima-Mwesigwa , Christian F. A. Negre , Susan M. Mniszewski

This manuscript provides a comprehensive review of the Maximum Clique Problem, a computational problem that involves finding subsets of vertices in a graph that are all pairwise adjacent to each other. The manuscript covers in a simple way…

Artificial Intelligence · Computer Science 2024-03-18 Raffaele Marino , Lorenzo Buffoni , Bogdan Zavalnij

The Minimum Bisection Problem is a well-known NP-hard problem in combinatorial optimization, with practical applications in areas such as parallel computing, network design, and machine learning. In this paper, we examine the potential of…

Quantum Physics · Physics 2025-09-24 Renáta Rusnáková , Martin Chovanec , Juraj Gazda

Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that promise to solve certain combinatorial optimization problems of practical relevance faster than their…

Quantum Physics · Physics 2016-05-31 Itay Hen , Federico M. Spedalieri

Here we consider using quantum annealing to solve Set Cover with Pairs (SCP), an NP-hard combinatorial optimization problem that play an important role in networking, computational biology, and biochemistry. We show an explicit construction…

Quantum Physics · Physics 2016-08-31 Yudong Cao , Shuxian Jiang , Debbie Perouli , Sabre Kais

The edge clique cover (ECC) problem -- where the goal is to find a minimum cardinality set of cliques that cover all the edges of a graph -- is a classic NP-hard problem that has received much attention from both the theoretical and…

Data Structures and Algorithms · Computer Science 2023-07-06 Anthony Hevia , Benjamin Kallus , Summer McClintic , Samantha Reisner , Darren Strash , Johnathan Wilson

In recent years, the expander decomposition method was used to develop many graph algorithms, resulting in major improvements to longstanding complexity barriers. This powerful hammer has led the community to (1) believe that most problems…

Data Structures and Algorithms · Computer Science 2022-11-28 Amir Abboud , Nathan Wallheimer

Quantum phenomena have the potential to speed up the solution of hard optimization problems. For example quantum annealing, based on the quantum tunneling effect, has recently been shown to scale exponentially better with system size as…

Quantum Physics · Physics 2017-04-27 Simon E. Nigg , Niels Loerch , Rakesh P. Tiwari

A $k$-defective clique of an undirected graph $G$ is a subset of its vertices that induces a nearly complete graph with a maximum of $k$ missing edges. The maximum $k$-defective clique problem, which asks for the largest $k$-defective…

Data Structures and Algorithms · Computer Science 2024-07-25 Chunyu Luo , Yi Zhou , Zhengren Wang , Mingyu Xiao

Quantum annealing is a novel type of analog computation that aims to use quantum mechanical fluctuations to search for optimal solutions of Ising problems. Quantum annealing in the Transverse Ising model, implemented on D-Wave QPUs, are…

Quantum Physics · Physics 2025-03-14 Elijah Pelofske

Clique problem has a wide range of applications due to its pattern matching ability. There are various formulation of clique problem like $k$-clique problem, maximum clique problem, etc. The $k$-Clique problem, determines whether an…

Emerging Technologies · Computer Science 2023-09-13 Arpita Sanyal , Amit Saha , Banani Saha , Amlan Chakrabarti

Cybersecurity in telecommunication networks often leads to hard combinatorial optimization problems that are challenging to solve with classical methods. This work investigates the practical feasibility of using quantum annealing to address…

Quantum Physics · Physics 2026-01-05 Ali Abbassi , Yann Dujardin , Eric Gourdin , Philippe Lacomme , Caroline Prodhon

Quantum annealing promises to be an effective heuristic for complex NP-hard problems. However, clear demonstrations of quantum advantage are wanting, primarily constrained by the difficulty of embedding the problem into the quantum…

Quantum Physics · Physics 2022-11-15 Minjae Jo , Michael Hanks , M. S. Kim

In this paper we present a novel strategy to solve optimization problems within a hybrid quantum-classical scheme based on quantum annealing, with a particular focus on QUBO problems. The proposed algorithm is based on an iterative…

Quantum Physics · Physics 2020-04-07 Enrico Blanzieri , Davide Pastorello

In the quantum optimization paradigm, variational quantum algorithms face challenges with hardware-specific and instance-dependent parameter tuning, which can lead to computational inefficiencies. The promising potential of parameter…

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