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Many mathematical models of synaptic plasticity have been proposed to explain the diversity of plasticity phenomena observed in biological organisms. These models range from simple interpretations of Hebb's postulate, which suggests that…

Neurons and Cognition · Quantitative Biology 2025-08-05 Danil Tyulmankov

To learn useful dynamics on long time scales, neurons must use plasticity rules that account for long-term, circuit-wide effects of synaptic changes. In other words, neural circuits must solve a credit assignment problem to appropriately…

Neurons and Cognition · Quantitative Biology 2019-05-30 Owen Marschall , Kyunghyun Cho , Cristina Savin

Our current understanding of neuroplasticity paints a picture of a complex interconnected system of dependent processes which shape cortical structure so as to produce an efficient information processing system. Indeed, the cooperation of…

Neurons and Cognition · Quantitative Biology 2018-04-03 Zoe Tosi , John Beggs

How can we build agents that keep learning from experience, quickly and efficiently, after their initial training? Here we take inspiration from the main mechanism of learning in biological brains: synaptic plasticity, carefully tuned by…

Neural and Evolutionary Computing · Computer Science 2018-08-01 Thomas Miconi , Jeff Clune , Kenneth O. Stanley

Developing reliable mechanisms for continuous local learning is a central challenge faced by biological and artificial systems. Yet, how the environmental factors and structural constraints on the learning network influence the optimal…

Neurons and Cognition · Quantitative Biology 2024-03-21 Emmanouil Giannakakis , Sina Khajehabdollahi , Anna Levina

How neuronal circuits achieve credit assignment remains a central unsolved question in systems neuroscience. Various studies have suggested plausible solutions for back-propagating error signals through multi-layer networks. These purely…

Neurons and Cognition · Quantitative Biology 2023-12-12 Julian Rossbroich , Friedemann Zenke

Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…

Neurons and Cognition · Quantitative Biology 2017-05-24 Sophie Denève , Alireza Alemi , Ralph Bourdoukan

Dynamical wiring and rewiring in neural networks are carried out by activity-dependent growth and retraction of axons and dendrites, guided by gudance molecules, released by target cells. Experience-dependent structural changes in cortical…

Neurons and Cognition · Quantitative Biology 2007-05-23 Fail M. Gafarov

Continuous adaptation allows survival in an ever-changing world. Adjustments in the synaptic coupling strength between neurons are essential for this capability, setting us apart from simpler, hard-wired organisms. How these changes can be…

Neurons and Cognition · Quantitative Biology 2021-01-06 Jakob Jordan , Maximilian Schmidt , Walter Senn , Mihai A. Petrovici

To guide behavior, the brain extracts relevant features from high-dimensional data streamed by sensory organs. Neuroscience experiments demonstrate that the processing of sensory inputs by cortical neurons is modulated by instructive…

Neurons and Cognition · Quantitative Biology 2020-10-27 Siavash Golkar , David Lipshutz , Yanis Bahroun , Anirvan M. Sengupta , Dmitri B. Chklovskii

We use a biophysical model of a local neuronal circuit to study the implications of synaptic plasticity for the detection of weak sensory stimuli. Networks with fast plastic coupling show behavior consistent with stochastic resonance.…

Neurons and Cognition · Quantitative Biology 2009-11-13 Vladislav Volman , Herbert Levine

Predictive coding (PC) networks are a biologically interesting class of neural networks. Their layered hierarchy mimics the reciprocal connectivity pattern observed in the mammalian cortex, and they can be trained using local learning rules…

Neural and Evolutionary Computing · Computer Science 2019-10-29 Jeff Orchard , Wei Sun

In the present paper, I describe a spiking neural network (SNN) architecture which, can be used in wide range of supervised learning classification tasks. It is assumed, that all participating signals (the classified object description,…

Neural and Evolutionary Computing · Computer Science 2025-03-13 Mikhail Kiselev

Spiking networks that perform probabilistic inference have been proposed both as models of cortical computation and as candidates for solving problems in machine learning. However, the evidence for spike-based computation being in any way…

Neural and Evolutionary Computing · Computer Science 2017-10-12 Luziwei Leng , Roman Martel , Oliver Breitwieser , Ilja Bytschok , Walter Senn , Johannes Schemmel , Karlheinz Meier , Mihai A. Petrovici

Synaptic plasticity dynamically shapes the connectivity of neural systems and is key to learning processes in the brain. To what extent the mechanisms of plasticity can be exploited to drive a neural network and make it perform some kind of…

Neurons and Cognition · Quantitative Biology 2024-12-03 Francesco Borra , Simona Cocco , Rémi Monasson

Patterns of microcircuitry suggest that the brain has an array of repeated canonical computational units. Yet neural representations are distributed, so the relevant computations may only be related indirectly to single-neuron…

Neurons and Cognition · Quantitative Biology 2023-10-17 Rajkumar Vasudeva Raju , Zhe Li , Scott Linderman , Xaq Pitkow

Molecular circuits capable of autonomous learning could unlock novel applications in fields such as bioengineering and synthetic biology. To this end, existing chemical implementations of neural computing have mainly relied on emulating…

Machine Learning · Computer Science 2025-09-23 Rajiv Teja Nagipogu , John H. Reif

Structure entails function and thus a structural description of the brain will help to understand its function and may provide insights into many properties of brain systems, from their robustness and recovery from damage, to their dynamics…

Neurons and Cognition · Quantitative Biology 2008-08-27 Marcus Kaiser , Robert Martin , Peter Andras , Malcolm P. Young

This PhD thesis is focused on the central idea that single neurons in the brain should be regarded as temporally precise and highly complex spatio-temporal pattern recognizers. This is opposed to the prevalent view of biological neurons as…

Neurons and Cognition · Quantitative Biology 2023-09-27 David Beniaguev

Sparse coding algorithms trained on natural images can accurately predict the features that excite visual cortical neurons, but it is not known whether such codes can be learned using biologically realistic plasticity rules. We have…

Neurons and Cognition · Quantitative Biology 2011-11-01 Joel Zylberberg , Jason Timothy Murphy , Michael Robert DeWeese