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Autocatalytic Sets are reaction networks theorised as networks at the basis of life. Their main feature is the ability of spontaneously emerging and self-reproducing. The Reflexively and Food-generated theory provides a formal definition of…

Molecular Networks · Quantitative Biology 2020-10-19 Alessandro Ravoni

Background: Autocatalytic sets are often considered a necessary (but not sufficient) condition for the origin and early evolution of life. Although the idea of autocatalytic sets was already conceived of many years ago, only recently have…

Molecular Networks · Quantitative Biology 2012-06-06 Wim Hordijk , Mike Steel

Background: The idea that autocatalytic sets played an important role in the origin of life is not new. However, the likelihood of autocatalytic sets emerging spontaneously has long been debated. Recently, progress has been made along two…

Molecular Networks · Quantitative Biology 2012-11-16 Wim Hordijk , Mike Steel

A model of $s$ interacting species is considered with two types of dynamical variables. The fast variables are the populations of the species and slow variables the links of a directed graph that defines the catalytic interactions among…

adap-org · Physics 2009-10-30 Sanjay Jain , Sandeep Krishna

The dominant paradigm in origin of life research is that of an RNA world. However, despite experimental progress towards the spontaneous formation of RNA, the RNA world hypothesis still has its problems. Here, we introduce a novel…

Molecular Networks · Quantitative Biology 2017-01-31 Wim Hordijk

Autocatalytic systems are very often incorporated in the "origin of life" models, a connection that has been analyzed in the context of the classical hypercycles introduced by Manfred Eigen. We investigate the dynamics of certain networks…

Dynamical Systems · Mathematics 2020-12-14 Gheorghe Craciun , Abhishek Deshpande , Badal Joshi , Polly Y. Yu

Self-sustaining autocatalytic networks play a central role in living systems, from metabolism at the origin of life, simple RNA networks, and the modern cell, to ecology and cognition. A collectively autocatalytic network that can be…

Molecular Networks · Quantitative Biology 2018-03-29 Mike Steel , Wim Hordijk

We consider the population dynamics of a set of species whose network of catalytic interactions is described by a directed graph. The relationship between the attractors of this dynamics and the underlying graph theoretic structures like…

adap-org · Physics 2009-10-30 Sanjay Jain , Sandeep Krishna

Autocatalysis, the ability of a chemical system to make more of itself, is a crucial feature in metabolism and is speculated to have played a decisive role in the origin of life. Nevertheless, how autocatalytic systems behave far from…

Chemical Physics · Physics 2024-10-23 Armand Despons

The concept of (auto)catalytic systems has become a cornerstone in understanding evolutionary processes in various fields. The common ground is the observation that for the production of new species/goods/ideas/elements etc. the…

Populations and Evolution · Quantitative Biology 2009-11-13 Rudolf Hanel , Peter Klimek , Stefan Thurner

The emergence of autocatalytic sets of molecules seems to have played an important role in the origin of life context. Although the possibility to reproduce this emergence in laboratory has received considerable attention, this is still far…

Adaptation and Self-Organizing Systems · Physics 2015-02-04 Alessandro Filisetti , Marco Villani , Chiara Damiani , Alex Graudenzi , Andrea Roli , Wim Hordijk , Roberto Serra

The emergence of self-sustaining autocatalytic networks in chemical reaction systems has been studied as a possible mechanism for modelling how living systems first arose. It has been known for several decades that such networks will form…

Molecular Networks · Quantitative Biology 2020-11-24 Stuart Kauffman , Mike Steel

Evolution produces complex and structured networks of interacting components in chemical, biological, and social systems. We describe a simple mathematical model for the evolution of an idealized chemical system to study how a network of…

Adaptation and Self-Organizing Systems · Physics 2014-03-05 Sanjay Jain , Sandeep Krishna

This paper presents new results from a detailed study of the structure of autocatalytic sets. We show how autocatalytic sets can be decomposed into smaller autocatalytic subsets, and how these subsets can be identified and classified. We…

Molecular Networks · Quantitative Biology 2012-05-07 Wim Hordijk , Mike Steel , Stuart Kauffman

We study a family of networks of autocatalytic reactions, which we call hyperchains, that are a generalization of hypercycles. Hyperchains, and the associated dynamical system called replicator equations, are a possible mechanism for…

Dynamical Systems · Mathematics 2021-04-23 Badal Joshi , Gheorghe Craciun

Autocatalysis is a deceptively simple concept, referring to the situation that a chemical species $X$ catalyzes its own formation. From the perspective of chemical kinetics, autocatalysts show a regime of super-linear growth. Given a…

Molecular Networks · Quantitative Biology 2021-07-08 Jakob L. Andersen , Christoph Flamm , Daniel Merkle , Peter F. Stadler

Autocatalytic sets are self-catalyzing and self-sustaining chemical reaction networks that are believed to have played an important role in the origin of life. They have been studied extensively both theoretically as well as experimentally.…

Molecular Networks · Quantitative Biology 2023-03-06 Wim Hordijk

Autocatalysis is a fundamental concept, used in a wide range of domains. From the most general definition of autocatalysis, that is a process in which a chemical compound is able to catalyze its own formation, several different systems can…

Biomolecules · Quantitative Biology 2011-10-05 Raphaël Plasson , Axel Brandenburg , Ludovic Jullien , Hugues Bersini

Over the last years, analyses performed on a stochastic model of catalytic reaction networks have provided some indications about the reasons why wet-lab experiments hardly ever comply with the phase transition typically predicted by…

Computational Engineering, Finance, and Science · Computer Science 2013-10-01 Chiara Damiani , Alessandro Filisetti , Alex Graudenzi , Marco Villani , Roberto Serra

Two alternative views of an economy are combined and studied. The first view is that of technological evolution as a process of combinatorial innovation. Recently a simple mathematical model (TAP) was introduced to study such a…

Molecular Networks · Quantitative Biology 2022-04-13 Wim Hordijk , Stuart Kauffman
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