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This paper discusses the fundamental principles of causal inference - the area of statistics that estimates the effect of specific occurrences, treatments, interventions, and exposures on a given outcome from experimental and observational…

Methodology · Statistics 2021-12-03 Francesca Dominici , Falco J. Bargagli-Stoffi , Fabrizia Mealli

The attributable risk, often called the population attributable risk, is in many epidemiological contexts a more relevant measure of exposure-disease association than the excess risk, relative risk, or odds ratio. When estimating…

Statistics Theory · Mathematics 2008-12-31 Daniel B. Rubin

Negative sampling schemes enable efficient training given a large number of classes, by offering a means to approximate a computationally expensive loss function that takes all labels into account. In this paper, we present a new connection…

Pragmatic clinical trials evaluate the effectiveness of health interventions in real-world settings. Negative spillover can arise in a pragmatic trial if the study intervention affects how scarce resources are allocated between patients in…

Methodology · Statistics 2024-12-20 Sean Mann

Association rule mining is an important problem in the data mining area. It enumerates and tests a large number of rules on a dataset and outputs rules that satisfy user-specified constraints. Due to the large number of rules being tested,…

Databases · Computer Science 2011-11-01 Guimei Liu , Haojun Zhang , Limsoon Wong

This review maps developments in stochastic modeling, highlighting non-standard approaches and their applications to biology and epidemiology. It brings together four strands: (1) core models for systems that evolve with randomness; (2)…

Dynamical Systems · Mathematics 2025-10-24 Yassine Sabbar , Kottakkaran Sooppy Nisar

Unmeasured confounding is a key challenge for causal inference. In this paper, we establish a framework for unmeasured confounding adjustment with negative control variables. A negative control outcome is associated with the confounder but…

Methodology · Statistics 2024-09-09 Wang Miao , Xu Shi , Yilin Li , Eric Tchetgen Tchetgen

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

Contact tracing is one of the most important control measures deployed during epidemics. Relying on the identification of contacts of known infected individuals, it necessitates a network perspective. Although pairwise models have been used…

Physics and Society · Physics 2026-03-05 Giulia de Meijere , Andrea Pugliese , Gerardo Iñiguez , Péter L. Simon , István Z. Kiss

Omitted variables are one of the most important threats to the identification of causal effects. Several widely used methods assess the impact of omitted variables on empirical conclusions by comparing measures of selection on observables…

Econometrics · Economics 2026-02-05 Paul Diegert , Matthew A. Masten , Alexandre Poirier

When constructing a model to estimate the causal effect of a treatment, it is necessary to control for other factors which may have confounding effects. Because the ignorability assumption is not testable, however, it is usually unclear…

Methodology · Statistics 2022-09-07 Spencer Woody , Carlos M. Carvalho , Jared S. Murray

Recent FDA guidance on adaptive clinical trial designs defines bias as "a systematic tendency for the estimate of treatment effect to deviate from its true value", and states that it is desirable to obtain and report estimates of treatment…

A popular framework for false discovery control is the random effects model in which the null hypotheses are assumed to be independent. This paper generalizes the random effects model to a conditional dependence model which allows…

Statistics Theory · Mathematics 2008-12-18 Wei Biao Wu

Though notable progress has been made, neural-based aspect-based sentiment analysis (ABSA) models are prone to learn spurious correlations from annotation biases, resulting in poor robustness on adversarial data transformations. Among the…

Computation and Language · Computer Science 2024-06-07 Jialong Wu , Linhai Zhang , Deyu Zhou , Guoqiang Xu

Causal analysis has become an essential component in understanding the underlying causes of phenomena across various fields. Despite its significance, existing literature on causal discovery algorithms is fragmented, with inconsistent…

Artificial Intelligence · Computer Science 2024-09-05 Wenjin Niu , Zijun Gao , Liyan Song , Lingbo Li

We analyze the methodological approach and validity of interpretation of using national-level time-series regression analyses relating epidemic outcomes to policies that estimate many models involving permutations of analytic choices (i.e.,…

Other Quantitative Biology · Quantitative Biology 2024-09-12 Jeremy D. Goldhaber-Fiebert

Methods for efficiently controlling dynamics propagated on networks are usually based on identifying the most influential nodes. Knowledge of these nodes can be used for the targeted control of dynamics such as epidemics, or for modifying…

Physics and Society · Physics 2017-11-07 Kieran J. Sharkey

In a context where most published articles are devoted to the development of "new methods", comparison studies are generally appreciated by readers but surprisingly given poor consideration by many scientific journals. In connection with…

Computation · Statistics 2015-06-11 Anne-Laure Boulesteix , Manuel J. A. Eugster

Epidemiological compartmental models are useful for understanding infectious disease propagation and directing public health policy decisions. Calibration of these models is an important step in offering accurate forecasts of disease…

Machine Learning · Computer Science 2023-12-12 Nikunj Gupta , Anh Mai , Azza Abouzied , Dennis Shasha

Background: Variables in epidemiological observational studies are commonly subject to measurement error and misclassification, but the impact of such errors is frequently not appreciated or ignored. As part of the STRengthening Analytical…