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We present a quantum annealing-based solution method for topology optimization (TO). In particular, we consider TO in a more general setting, i.e., applied to structures of continuum domains where designs are represented as distributed…

Numerical Analysis · Mathematics 2023-01-30 Zisheng Ye , Xiaoping Qian , Wenxiao Pan

We show how a digitized version of Quantum Annealing can be made optimal, realizing the best possible solution allowed by quantum mechanics in the shortest time, without any prior knowledge on the location and properties of the spectral…

Quantum Physics · Physics 2019-11-28 Glen Bigan Mbeng , Rosario Fazio , Giuseppe E. Santoro

A genetic algorithm (GA) is a search-based optimization technique based on the principles of Genetics and Natural Selection. We present an algorithm which enhances the classical GA with input from quantum annealers. As in a classical GA,…

Quantum Physics · Physics 2022-09-16 Steven Abel , Luca A. Nutricati , Michael Spannowsky

We present a classical algorithm to find approximate solutions to instances of quadratic unconstrained binary optimisation. The algorithm can be seen as an analogue of quantum annealing under the restriction of a product state space, where…

Quantum Physics · Physics 2023-02-14 Joseph Bowles , Alexandre Dauphin , Patrick Huembeli , José Martinez , Antonio Acín

Feature selection is a machine learning technique for identifying relevant variables in classification and regression models. In single-cell RNA sequencing (scRNA-seq) data analysis, feature selection is used to identify relevant genes that…

Genomics · Quantitative Biology 2025-12-02 Selim Romero , Shreyan Gupta , Victoria Gatlin , Robert S. Chapkin , James J. Cai

In the evaluation of quantum annealers, metrics based on ground state success rates have two major drawbacks. First, evaluation requires computation time for both quantum and classical processors that grows exponentially with problem size.…

Quantum Physics · Physics 2015-08-21 James King , Sheir Yarkoni , Mayssam M. Nevisi , Jeremy P. Hilton , Catherine C. McGeoch

We present Counterdiabatic Reverse Annealing, a novel quantum annealing protocol that extends the range of application of reverse annealing to the previously inaccessible short-time domain. This is achieved by exploiting approximate…

Quantum Physics · Physics 2023-02-09 Gianluca Passarelli , Procolo Lucignano

Quenching and annealing are extreme opposites in the time evolution of a quantum system: Annealing explores equilibrium phases of a Hamiltonian with slowly changing parameters and can be exploited as a tool for solving complex optimization…

Quantum Physics · Physics 2022-01-19 Bernhard Irsigler , Tobias Grass

Quantum computation offers exciting new possibilities for statistics. This paper explores the use of the D-Wave machine, a specialized type of quantum computer, which performs quantum annealing. A general description of quantum annealing…

Computation · Statistics 2019-11-21 Robert C. Foster , Brian Weaver , James Gattiker

Transcription factors regulate gene expression, but how these proteins recognize and specifically bind to their DNA targets is still debated. Machine learning models are effective means to reveal interaction mechanisms. Here we studied the…

Quantum Physics · Physics 2018-03-02 Richard Y. Li , Rosa Di Felice , Remo Rohs , Daniel A. Lidar

Stochastic Unit Commitment (SUC) has been proposed to manage the uncertainties driven by renewable integration, but it leads to significant computational complexity. When accelerated by Benders Decomposition (BD), the master problem becomes…

Quantum Physics · Physics 2026-02-25 Wei Hong , Wangkun Xu , Fei Teng

Critical decision-making issues in science, engineering, and industry are based on combinatorial optimization; however, its application is inherently limited by the NP-hard nature of the problem. A specialized paradigm of analogue quantum…

Quantum Physics · Physics 2026-02-04 Rudraksh Sharma , Ravi Katukam , Arjun Nagulapally

Retrieval-Augmented Generation (RAG) has emerged as a powerful paradigm for enhancing the performance of large language models (LLMs) by integrating external knowledge into the generation process. A key component of RAG pipelines is the…

Computation and Language · Computer Science 2025-04-07 Yuwei An , Yihua Cheng , Seo Jin Park , Junchen Jiang

This paper presents two novel approaches for solving the set cover problem (SCP) with multiple inequality constraints on quantum annealers. The first method uses the augmented Lagrangian approach to represent the constraints, while the…

Quantum Physics · Physics 2023-02-23 Hristo N. Djidjev

We compare the performance of four quantum annealers, the D-Wave Two, 2X, 2000Q, and Advantage in solving an identical ensemble of a parametrized family of scheduling problems. These problems are NP-complete and, in fact, equivalent to…

Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealing optimizers that contain hundreds of quantum bits. These optimizers, named `D-Wave' chips, promise to solve…

Quantum Physics · Physics 2015-10-23 Victor Martin-Mayor , Itay Hen

Classical and quantum annealing are computing paradigms that have been proposed to solve a wide range of optimization problems. In this paper, we aim to enhance the performance of annealing algorithms by introducing the technique of…

Quantum Physics · Physics 2022-09-13 Eric R. Anschuetz , Lena Funcke , Patrick T. Komiske , Serhii Kryhin , Jesse Thaler

A technique inspired on quantum annealing is proposed in order to obtain the classical ground state of a spin-glass by tracking the full wavefunction of a given system within the subspace of matrix product states (MPS), using the density…

Quantum Physics · Physics 2007-05-23 Javier Rodriguez-Laguna

Quantum annealing is a heuristic algorithm for searching the ground state of an Ising model. Heuristic algorithms aim to obtain near-optimal solutions with a reasonable computation time. Accordingly, many algorithms have so far been…

Quantum Physics · Physics 2022-11-09 Shuntaro Okada , Masayuki Ohzeki

Quantum technology is maturing to the point where quantum devices, such as quantum communication systems, quantum random number generators and quantum simulators, may be built with capabilities exceeding classical computers. A quantum…