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There is significant interest in modelling the mechanics and physics of growth of soft biological systems such as tumors and bacterial biofilms. Solid tumors account for more than 85% of cancer mortality and bacterial biofilms account for a…

Soft Condensed Matter · Physics 2024-03-29 Chockalingam Senthilnathan , Tal Cohen

A large variety of materials, widely encountered both in engineering applications and in the biological realm, are characterised by a non-vanishing internal stress distribution, even in the absence of external deformations or applied…

Soft Condensed Matter · Physics 2024-03-15 Artur L. Gower , Tom Shearer , Pasquale Ciarletta , Michel Destrade

The properties of slow crack growth in brittle materials are analyzed both theoretically and experimentally. We propose a model based on a thermally activated rupture process. Considering a 2D spring network submitted to an external load…

Materials Science · Physics 2009-11-13 Stéphane Santucci , Loic Vanel , Sergio Ciliberto

Certain bacteria form filamentous colonies when the cells fail to separate after dividing. In Bacillus subtilis, Bacillus thermus, and cyanobacteria, the filaments can wrap into complex supercoiled structures as the cells grow. The…

Soft Condensed Matter · Physics 2010-05-26 Charles W. Wolgemuth , Raymond E. Goldstein , Thomas R. Powers

Angular channel extrusion has evolved as processes that can induce significant strengthening of the formed product through grain refinement. However, significant residual stresses are developed in the extruded product whose quantification…

Computational Engineering, Finance, and Science · Computer Science 2021-01-08 Arunava Ray , Pritam Chakraborty , Anindya Chatterjee

To produce sounds, we adjust the tension of our vocal folds to shape their properties and control the pitch. This efficient mechanism offers inspiration for designing reconfigurable materials and adaptable soft robots. However,…

Soft Condensed Matter · Physics 2025-06-18 Alexandre Delory , Daniel A. Kiefer , Maxime Lanoy , Antonin Eddi , Claire Prada , Fabrice Lemoult

We derive a course grained, continuum model of the 2D vertex model, applicable for different underlying geometries, and allowing for analytical analysis of an otherwise numerical model. Using a geometric approach and out--of--equilibrium…

Soft Condensed Matter · Physics 2022-08-31 Doron Grossman , Jean-Francois Joanny

The production of mechanical stresses in living organisms largely relies on localized, force-generating active units embedded in filamentous matrices. Numerical simulations of discrete fiber networks with fixed boundaries have shown that…

Biological Physics · Physics 2018-05-10 Pierre Ronceray , Chase Broedersz , Martin Lenz

During growth, tissue expands and deforms. Given its elastic properties, stresses emerge in an expanding and deforming tissue. Cell rearrangements can dissipate these stresses and numerous experiments confirm the viscoelastic properties of…

Tissues and Organs · Quantitative Biology 2017-10-20 M. D. Peters , D. Iber

In growing active matter systems, a large collection of engineered or living autonomous units metabolize free energy and create order at different length scales as they proliferate and migrate collectively. One such example is bacterial…

Soft Condensed Matter · Physics 2021-06-15 Japinder Nijjer , Changhao Li , Qiuting Zhang , Haoran Lu , Sulin Zhang , Jing Yan

Bacillus subtilis biofilms were grown in laminar channel flow at wall shear stress spanning one order of magnitude ($\tau_w = 0.068$ Pa to $\tau_w = 0.67$ Pa). We monitor, non-invasively, the evolution of the three-dimensional distribution…

We consider pattern formation in periodically forced binary systems. In particular we focus on systems in which the two species are differentially forced, one being accelerated with respect to the other. Using a continuum model consisting…

Materials Science · Physics 2007-05-23 C. M. Pooley , J. M. Yeomans

We investigate certain aspects of the physical mechanisms of root growth in a granular medium and how these roots adapt to changes in water distribution induced by the presence of structural inhomogeneities in the form of solid intrusions.…

The mechanics of animal cells is strongly determined by stress fibers, which are contractile filament bundles that form dynamically in response to extracellular cues. Stress fibers allow the cell to adapt its mechanics to environmental…

Biological Physics · Physics 2024-10-15 Lukas Riedel , Valentin Wössner , Dominic Kempf , Falko Ziebert , Peter Bastian , Ulrich S. Schwarz

Extensibility is beyond the paradigm of classical soft glassy materials, and more broadly, yield-stress fluids. Recently, model yield-stress fluids with significant extensibility have been designed by adding polymeric phases to classically…

Soft Condensed Matter · Physics 2023-11-29 Samya Sen , Rubens R. Fernandes , Randy H. Ewoldt

Spatial patterns arising spontaneously due to internal processes are ubiquitous in nature, varying from regular patterns of dryland vegetation to complex structures of bacterial colonies. Many of these patterns can be explained in the…

Pattern Formation and Solitons · Physics 2017-08-02 Yuval R. Zelnik , Omer Tzuk

Gene expression is inherently noisy, posing a challenge to understanding how precise and reproducible patterns of gene expression emerge in mammals. We investigate this phenomenon using gastruloids, an in vitro model for early mammalian…

Cell Behavior · Quantitative Biology 2025-11-19 Melody Merle , Leah Friedman , Corinne Chureau , Armin Shoushtarizadeh , Thomas Gregor

Subjected to compressive stresses, soft polymers with stiffness gradients can display various buckling patterns. These compressive stresses can have different origins, like mechanical forces, temperature changes, or, for hydrogel materials,…

Soft Condensed Matter · Physics 2019-10-18 Arne Ilseng , Victorien Prot , Bjørn T. Stokke , Bjørn H. Skallerud

Growing experimental evidence highlights the relevant role of mechanics in the physiology of solid tumours, even in their early stages. While most of the mathematical models describe tumour growth as a volumetric increase of mass in the…

Biological Physics · Physics 2025-05-19 D. Riccobelli

Convergence extension, the simultaneous elongation of tissue along one axis while narrowing along a perpendicular axis, occurs during embryonic development. A fundamental process that contributes to shaping the organism, it happens in many…

Soft Condensed Matter · Physics 2023-03-06 Aondoyima Ioratim-Uba , Tanniemola B. Liverpool , Silke Henkes