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Nearly all cell models explicitly or implicitly deal with the biophysical constraints that must be respected for life to persist. Despite this, there is almost no systematicity in how these constraints are implemented, and we lack a…

Cell Behavior · Quantitative Biology 2026-05-20 Connor McShaffrey , Eran Agmon , Randall D. Beer

Biology has taken strong steps towards becoming a computer science aiming at reprogramming nature after the realisation that nature herself has reprogrammed organisms by harnessing the power of natural selection and the digital prescriptive…

Neural and Evolutionary Computing · Computer Science 2016-01-21 Hector Zenil , Angelika Schmidt , Jesper Tegnér

This paper discusses the meaning and scope of biological hypercomputation (BH). The framework here is computational, and from the outset it should be clear that life is not a standard Turing Machine. Living systems hypercompute, but the…

Adaptation and Self-Organizing Systems · Physics 2012-10-18 Carlos Eduardo Maldonado , Nelson Alfonso Gomez-Cruz

The claim that life is an emergent phenomenon exhibiting novel properties and principles is often criticized for being in conflict with causal closure at the microscopic level. I argue that advances in cosmological theory suggesting an…

Astrophysics · Physics 2007-05-23 P. C. W. Davies

While fields like Artificial Life have made huge strides in quantifying the mechanisms that distinguish living systems from non-living ones, particular mechanisms remain difficult to reproduce in silico. Known as open-endedness, we've been…

Biological Physics · Physics 2024-07-18 Alyssa M Adams , Eliott Jacopin , Praful Gagrani , Olaf Witkowski

This paper considers neural representation through the lens of active inference, a normative framework for understanding brain function. It delves into how living organisms employ generative models to minimize the discrepancy between…

Neurons and Cognition · Quantitative Biology 2023-10-24 Giovanni Pezzulo , Leo D'Amato , Francesco Mannella , Matteo Priorelli , Toon Van de Maele , Ivilin Peev Stoianov , Karl Friston

We describe several techniques for using bulk matter for special purpose computation. In each case it is necessary to use an evolutionary algorithm to program the substrate on which the computation is to take place. In addition, the…

Other Condensed Matter · Physics 2007-05-23 Simon L. Harding , Julian F. Miller , Edward A. Rietman

There has been on-going philosophical debate on whether artificial life models, also known as digital organisms, are truly alive. The main difficulty appears to be finding an encompassing and definite definition of life. By examining…

Neural and Evolutionary Computing · Computer Science 2023-02-22 Yong Zher Koh , Maurice HT Ling

In equilibrium, the physical properties of matter are set by the interactions between the constituents. In contrast, the energy input of the individual components controls the behavior of synthetic or living active matter. Great progress…

Soft Condensed Matter · Physics 2025-08-29 Q. Martinet , Y. Li , A. Aubret , E. Hannezo , J. Palacci

The increase of existing computational capabilities has made simulation emerge as a third discipline of Science, lying midway between experimental and purely theoretical branches [1, 2]. Simulation enables the evaluation of quantities which…

Computational Physics · Physics 2015-06-05 Pablo García-Risueño , Pablo E. Ibáñez

This paper presents the principal challenges and opportunities associated with computational biomechanics research. The underlying cognitive control involved in the process of human motion is inherently complex, dynamic, multidimensional,…

The fields of computing and biology have begun to cross paths in new ways. In this paper a review of the current research in biological computing is presented. Fundamental concepts are introduced and these foundational elements are explored…

Computational Engineering, Finance, and Science · Computer Science 2009-11-10 Balaji Akula , James Cusick

To better understand the deep significance of our best physical theories it could be interesting to compare our Universe with its models. It may happen that the differences between the model and reality can be made indistinguishable, to the…

General Physics · Physics 2009-11-11 Giorgio Fontana

The emergence of "big data" offers unprecedented opportunities for not only accelerating scientific advances but also enabling new modes of discovery. Scientific progress in many disciplines is increasingly enabled by our ability to examine…

Computers and Society · Computer Science 2017-07-03 Vasant G. Honavar , Mark D. Hill , Katherine Yelick

Although it has been notoriously difficult to pin down precisely what it is that makes life so distinctive and remarkable, there is general agreement that its informational aspect is one key property, perhaps the key property. The unique…

Adaptation and Self-Organizing Systems · Physics 2012-12-20 Sara Imari Walker , Paul C. W. Davies

This text presents the research field of natural/unconventional computing as it appears in the book COMPUTING NATURE. The articles discussed consist a selection of works from the Symposium on Natural Computing at AISB-IACAP (British Society…

General Literature · Computer Science 2012-10-30 Gordana Dodig Crnkovic , Raffaela Giovagnoli

Life is confronted with computation problems in a variety of domains including animal behavior, single-cell behavior, and embryonic development. Yet we currently do not know of a naturally existing biological system that is capable of…

Other Quantitative Biology · Quantitative Biology 2022-03-10 Hessameddin Akhlaghpour

The introduction of large language models has significantly expanded global demand for computing; addressing this growing demand requires novel approaches that introduce new capabilities while addressing extant needs. Although inspiration…

Neural and Evolutionary Computing · Computer Science 2026-02-04 Wilkie Olin-Ammentorp

The molecular biology revolution of the last seventy five years has transformed our view of living systems. Scientific explanations of biological phenomena are now synonymous with the identification of the genes, proteins, and signaling…

Biological Physics · Physics 2024-10-29 Pankaj Mehta

With increased access to data and the advent of computers, the use of statistical tools and numerical simulations is becoming commonplace for ecologists. These approaches help improve our understanding of ecological phenomena and their…

Other Quantitative Biology · Quantitative Biology 2025-04-08 Maxime Clenet , Maxime Dion , F. Guillaume Blanchet