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Antibiotic resistance is a major threat to global health. It emerges in multispecies microbial communities under antibiotic exposure. This makes antibiotic spectrum -- a drug's distribution of effects across species -- a potential key…

Populations and Evolution · Quantitative Biology 2026-04-21 Magnus Aspenberg , Erik Andreas Martens , Kristofer Wollein Waldetoft

In the past years, a remarkable mapping has been found between the dynamics of a population of M individuals undergoing random mutations and selection, and that of a single system in contact with a thermal bath with temperature 1/M. This…

Statistical Mechanics · Physics 2015-07-28 Tommaso Brotto , Guy Bunin , Jorge Kurchan

The role of the selection pressure and mutation amplitude on the behavior of a single-species population evolving on a two-dimensional lattice, in a periodically changing environment, is studied both analytically and numerically. The…

Populations and Evolution · Quantitative Biology 2009-11-13 Ioana Bena , Michel Droz , Janusz Szwabinski , Andrzej Pekalski

Migration between different habitats is ubiquitous among biological populations. In this Letter, we study a simple quasispecies model for evolution in two different habitats, with different fitness landscapes, coupled through one-way…

Populations and Evolution · Quantitative Biology 2010-12-23 Bartlomiej Waclaw , Rosalind J. Allen , Martin R. Evans

The transition from localized to systemic spreading of bacteria, viruses and other agents is a fundamental problem that spans medicine, ecology, biology and agriculture science. We have conducted experiments and simulations in a simple…

Populations and Evolution · Quantitative Biology 2009-11-10 Anna L. Lin , Bernward A. Mann , Gelsy Torres-Oviedo , Bryan Lincoln , Josef Kas , Harry L. Swinney

The segregation of plasmids in a bacterial population is investigated. Hereby, a dynamical model is formulated in terms of a size-structured population using a hyperbolic partial differential equation incorporating non-local terms (the…

Populations and Evolution · Quantitative Biology 2017-01-13 Johannes Müller , Karin Münch , Bendix Koopmann , Eva Stadler , Louisa Roselius , Dieter Jahn , Richard Münch

The aim of this paper is to study two models for a bacterial population subject to antibiotic treatments. It is known that some bacteria are sensitive to antibiotics. These bacteria are in a state called persistence and each bacterium can…

Probability · Mathematics 2013-04-15 Fabio Zucca

We study the growth of a population of bacteria in a dynamical hostile environment corresponding to the immune system of the colonised organism. The immune cells evolve as subcritical open clusters of oriented percolation and are…

Populations and Evolution · Quantitative Biology 2013-10-07 Olivier Garet , Régine Marchand

In this paper, we inspect well-known population genetics and social dynamics models. In these models, interacting individuals, while participating in a self-organizing process, give rise to the emergence of complex behaviors and patterns.…

Populations and Evolution · Quantitative Biology 2012-07-11 Sven Banisch , Tanya Araújo

In the growth of bacterial colonies, a great variety of complex patterns are observed in experiments, depending on external conditions and the bacterial species. Typically, existing models employ systems of reaction-diffusion equations or…

Biological Physics · Physics 2019-11-12 Lautaro Vassallo , David Hansmann , Lidia A. Braunstein

We discuss a simple model of co-evolution. In order to emphasise the effect of interaction between individuals the entire population is subjected to the same physical environment. Species are emergent structures and extinction, origination…

Statistical Mechanics · Physics 2007-05-23 Kim Christensen , Simone A. di Collobiano , Matt Hall , Henrik J. Jensen

Antibiotic resistance is a growing public health problem. To gain a fundamental understanding of resistance evolution, a combination of systematic experimental and theoretical approaches is required. Evolution experiments combined with…

Populations and Evolution · Quantitative Biology 2021-05-24 Gabriela Petrungaro , Yuval Mulla , Tobias Bollenbach

We analyse a series of bacterial growth models with in-built inter-individual variation in rates of cell division. We show that this variation leads to reduced population growth in favorable regimes and reduced population killing in…

Populations and Evolution · Quantitative Biology 2025-11-05 John A. Mackenzie , Adam Hillman , M. Gabriela M. Gomes

Biological and social systems are structured at multiple scales, and the incentives of individuals who interact in a group may diverge from the collective incentive of the group as a whole. Mechanisms to resolve this tension are responsible…

Populations and Evolution · Quantitative Biology 2023-05-31 Daniel B. Cooney , Simon A. Levin , Yoichiro Mori , Joshua B. Plotkin

In recent decades freshwater lakes have seen an increase in human presence. A common byproduct of this human presence is eutrophication, which readily results in harmful cyanobacteria blooms. In this work we propose a model that couples the…

Physics and Society · Physics 2021-08-17 Christopher M. Heggerud , Hao Wang , Mark A. Lewis

We consider a model for a population in a heterogeneous environment, with logistic type local population dynamics, under the assumption that individuals can switch between two different nonzero rates of diffusion. Such switching behavior…

Analysis of PDEs · Mathematics 2020-01-14 Robert Stephen Cantrell , Chris Cosner , Xiao Yu

The spatio-temporal dynamics of a population present one of the most fascinating aspects and challenges for ecological modelling. In this article we review some simple mathematical models, based on one dimensional…

Populations and Evolution · Quantitative Biology 2008-11-18 A. B. Ryabov , B. Blasius

Statistical physics can describe the behavior of microbial populations consisting of many heterogeneous individuals. A direct consequence is the existence of phase transitions, where the behavior of a population changes discontinuously upon…

Populations and Evolution · Quantitative Biology 2026-04-20 Kaan Öcal , Syrine Ghrabli , Michael P. H. Stumpf

We introduce and discuss a kinetic framework describing the time evolution of the statistical distributions of a population divided into the compartments of susceptible, infectious, recovered, and resistant in the presence of a microbial…

Populations and Evolution · Quantitative Biology 2026-05-07 Marco Menale , Giuseppe Toscani , Mattia Zanella

In multicellular organisms, several cell states coexist. For determining each cell type, cell-cell interactions are often essential, in addition to intracellular gene expression dynamics. Based on dynamical systems theory, we propose a…

Cell Behavior · Quantitative Biology 2007-12-05 Akihiko Nakajima , Kunihiko Kaneko