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Genetic data are often used to infer demographic history and changes or detect genes under selection. Inferential methods are commonly based on models making various strong assumptions: demography and population structures are supposed…

Populations and Evolution · Quantitative Biology 2020-07-28 Clotilde Lepers , Sylvain Billiard , Matthieu Porte , Sylvie Méléard , Viet Chi Tran

We consider the Moran model of population genetics with two types, mutation, and selection, and investigate the line of descent of a randomly-sampled individual from a contemporary population. We trace this ancestral line back into the…

Probability · Mathematics 2024-05-22 Ellen Baake , Enrico Di Gaspero , Fernando Cordero

We introduce particle systems in one or more dimensions in which particles perform branching Brownian motion and the population size is kept constant equal to $N > 1$, through the following selection mechanism: at all times only the $N$…

Probability · Mathematics 2013-05-02 Nathanael Berestycki , Lee Zhuo Zhao

Population genetics theory has laid the foundations for genomics analyses including the recent burst in genome scans for selection and statistical inference of past demographic events in many prokaryote, animal and plant species.…

Populations and Evolution · Quantitative Biology 2014-01-22 Aurelien Tellier , Christophe Lemaire

Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals. In the past decade, detailed…

Populations and Evolution · Quantitative Biology 2014-08-19 Jeremy J. Berg , Graham Coop

Consider a haploid population which has evolved through an exchangeable reproduction dynamics, and in which all individuals alive at time $t$ have a most recent common ancestor (MRCA) who lived at time $A_t$, say. As time goes on, not only…

Probability · Mathematics 2007-05-23 P. Pfaffelhuber , A. Wakolbinger

Kingman's coalescent is one of the most popular models in population genetics. It describes the genealogy of a population whose genetic composition evolves in time according to the Wright-Fisher model, or suitable approximations of it…

Methodology · Statistics 2018-04-20 Stefano Favaro , Shui Feng , Paul A. Jenkins

We consider diploid bi-parental analogues of Cannings models: in a population of fixed size $N$ the next generation is composed of $V_{i,j}$ offspring from parents $i$ and $j$, where $V=(V_{i,j})_{1\le i\neq j \le N}$ is a (jointly)…

Probability · Mathematics 2018-03-29 Matthias Birkner , Huili Liu , Anja Sturm

Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from…

Populations and Evolution · Quantitative Biology 2013-01-04 Adel Dayarian , Boris I Shraiman

The Ancestral Selection Graph (ASG) is an important genealogical process which extends the well-known Kingman coalescent to incorporate natural selection. We show that the number of lineages of the ASG with and without mutation is…

Probability · Mathematics 2020-12-23 Philip A. Hanson , Paul A. Jenkins , Jere Koskela , Dario Spanò

Mathematical models of genetic evolution often come in pairs, connected by a so-called duality relation. The most seminal example are the Wright-Fisher diffusion and the Kingman coalescent, where the former describes the stochastic…

Probability · Mathematics 2024-02-02 Jere Koskela , Krzysztof Łatuszyński , Dario Spanò

We are interested in the evolving genealogy of a birth and death process with trait structure and ecological interactions. Traits are hereditarily transmitted from a parent to its offspring unless a mutation occurs. The dynamics may depend…

Probability · Mathematics 2012-06-20 Sylvie Méléard , Viet Chi Tran

We investigate the behaviour of the genealogy of a Wright-Fisher population model under the influence of a strong seed-bank effect. More precisely, we consider a simple seed-bank age distribution with two atoms, leading to either classical…

Probability · Mathematics 2014-03-13 Jochen Blath , Bjarki Eldon , Adrián González Casanova , Noemi Kurt

Consider a population evolving from year to year through three seasons: spring, summer and winter. Every spring starts with $N$ dormant individuals waking up independently of each other according to a given distribution. Once an individual…

We study a class of coalescents derived from a sampling procedure out of N i.i.d. Pareto(alpha) random variables, normalized by their sum, including beta-size-biasing on total length effects (beta < alpha). Depending on the range of alpha,…

Probability · Mathematics 2013-02-26 Thierry Huillet

We introduce a multi-allele Wright-Fisher model with non-recurrent, reversible mutation and directional selection. In this setting, the allele frequencies at a single locus track the path of a hybrid jump-diffusion process with state space…

Probability · Mathematics 2023-02-16 Ingemar Kaj , Carina F. Mugal , Rebekka Müller

A haplotype block, or simply a block, is a chromosomal segment, DNA base sequence or string that occurs in only a few variants or types in the genomes of a population of interest, and that has an encapsulated or 'private' frequency…

Populations and Evolution · Quantitative Biology 2024-06-21 Oliver Keatinge Clay

We are concerned with a special form of the (stochastic) Allen-Cahn equation, which can be seen as a model of hybrid zones in population genetics. Individuals in the population can be of one of three types; $aa$ are fitter than $AA$, and…

Probability · Mathematics 2022-04-04 Alison M. Etheridge , Mitchell D. Gooding , Ian Letter

Gene conversion is a mechanism by which a double-strand break in a DNA molecule is repaired using a homologous DNA molecule as a template. As a result, one gene is 'copied and pasted' onto the other gene. It was recently reported that the…

Populations and Evolution · Quantitative Biology 2013-04-08 Shuhei Mano

We define a general class of models representing natural selection between two alleles. The population size and spatial structure are arbitrary, but fixed. Genetics can be haploid, diploid, or otherwise; reproduction can be asexual or…

Populations and Evolution · Quantitative Biology 2021-02-05 Benjamin Allen , Alex McAvoy