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We developed an optical-resolution photoacoustic microscope (OR-PAM) capable of changing focal plane with high-speed by using a tunable acoustic gradient (TAG) lens. In our system, a TAG lens is designed to continuously changing the focal…

Optics · Physics 2020-09-09 Xianlin Song

Photoacoustic microscopy with large depth of focus is significant to the biomedical research. The conventional optical-resolution photoacoustic microscope (OR-PAM) suffers from limited depth of field (DoF) since the employed focused…

Image and Video Processing · Electrical Eng. & Systems 2020-09-07 Xianlin Song , Jianshuang Wei , Lingfang Song

We demonstrate Optical-Resolution Photoacoustic Microscopy (OR-PAM), where the optical field is focused and scanned using Digital Phase Conjugation (DPC) through a multimode fiber. The focus is scanned across the field of view using digital…

Photoacoustic microscopy (PAM) is a promising imaging modality because it is able to reveal optical absorption contrast in high resolution on the order of a micrometer. It can be applied in an endoscopic approach by implementing PAM into a…

Medical Physics · Physics 2019-11-22 Zhendong Guo , Zhanhong Ye , Weihao Shao , Lili Jing , Sung-Liang Chen

Acoustic-resolution photoacoustic microscopy (AR-PAM) is a promising tool for microvascular imaging. In the focal region, resolution of AR-PAM is determined by the ultrasound transducer and ultimately limited by acoustic diffraction. In the…

Image and Video Processing · Electrical Eng. & Systems 2021-11-22 Fei Feng , Siqi Liang , Sung-Liang Chen

In Photoacoustic imaging (PA), Delay-and-Sum (DAS) beamformer is a common beamforming algorithm having a simple implementation. However, it results in a poor resolution and high sidelobes. To address these challenges, a new algorithm namely…

Signal Processing · Electrical Eng. & Systems 2018-02-13 Moein Mozaffarzadeh , Ali Mahloojifar , Mahdi Orooji , Karl Kratkiewicz , Saba Adabi , Mohammadreza Nasiriavanaki

We present an ultra-thin hybrid imaging system based on an optical multimode fiber (MMF) and an optical fiber hydrophone that combines optical resolution photoacoustic and fluorescence microscopy. To control the illumination at the distal…

Fourier ptychography microscopy (FPM), sharing its roots with synthetic aperture technique and phase retrieval method, is a recently developed computational microscopic super-resolution technique. By turning on the light-emitting diode…

Optics · Physics 2021-05-07 G. Zhou , S. Zhang , C. Zheng , T. Li , Y. Hu , Q. Hao

Photoacoustic microscopy is becoming an important tool for the biomedical research. It has been widely used in biological researches, such as structural imaging of vasculature, brain structural and functional imaging, and tumor detection.…

Image and Video Processing · Electrical Eng. & Systems 2020-09-09 Xianlin Song , Jianshuang Wei , Lingfang Song

Photoacoustic microscopy (PAM) is a novel implementation of photoacoustic imaging (PAI) for visualizing the 3D bio-structure, which is realized by raster scanning of the tissue. However, as three involved critical imaging parameters,…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhengyuan Zhang , Haoran Jin , Zesheng Zheng , Wenwen Zhang , Wenhao Lu , Feng Qin , Arunima Sharma , Manojit Pramanik , Yuanjin Zheng

Photoacoustic tomography (PAT) is an emerging technology for biomedical imaging that combines the superiorities of high optical contrast and acoustic penetration. In the PAT system, more photoacoustic (PA) signals are preferred to be…

Instrumentation and Detectors · Physics 2020-12-09 Daohuai Jiang , Hengrong Lan , Yiyun Wang , Feng Gao , Fei Gao

Photoacoustic microscopy holds the potential to measure biomarkers' structural and functional status without labels, which significantly aids in comprehending pathophysiological conditions in biomedical research. However, conventional…

Image and Video Processing · Electrical Eng. & Systems 2025-06-05 Wangting Zhou , Jiangshan He , Tong Cai , Lin Wang , Zhen Yuan , Xunbin Wei , Xueli Chen

Photoacoustic imaging (PAI) is an emerging biomedical imaging modality capable of providing both high contrast and high resolution of optical and UltraSound (US) imaging. When a short duration laser pulse illuminates the tissue as a target…

Signal Processing · Electrical Eng. & Systems 2018-01-19 Moein Mozaffarzadeh , Ali Mahloojifar , Mahdi Orooji

Photoacoustic imaging (PAI) is an emerging medical imaging modality capable of providing high spatial resolution of Ultrasound (US) imaging and high contrast of optical imaging. Delay-and-Sum (DAS) is the most common beamforming algorithm…

Signal Processing · Electrical Eng. & Systems 2018-01-24 Moein Mozaffarzadeh , Ali Mahloojifar , Mahdi Orooji , Saba Adabi , Mohammadreza Nasiriavanaki

Multimode fibres are becoming increasingly attractive in optical endoscopy as they promise to enable unparalleled miniaturisation, spatial resolution and cost as compared to conventional fibre bundle-based counterpart. However, achieving…

Medical Physics · Physics 2024-06-05 Tianrui Zhao , Michelle T. Ma , Sebastien Ourselin , Tom Vercauteren , Wenfeng Xia

Ultrafast optical imaging has enabled direct observation of femtosecond-nanosecond dynamics, yet three-dimensional (3D) dynamic measurements at high numerical aperture (NA) remain hindered by the intrinsically shallow depth of field (DoF)…

Photoacoustic microscopy (PAM) is an emerging imaging method combining light and sound. However, limited by the laser's repetition rate, state-of-the-art high-speed PAM technology often sacrifices spatial sampling density (i.e.,…

Image and Video Processing · Electrical Eng. & Systems 2021-04-09 Tri Vu , Anthony DiSpirito , Daiwei Li , Zixuan Zhang , Xiaoyi Zhu , Maomao Chen , Laiming Jiang , Dong Zhang , Jianwen Luo , Yu Shrike Zhang , Qifa Zhou , Roarke Horstmeyer , Junjie Yao

Photoacoustic tomography leverages ultrasound's deep tissue penetration to retrieve optical absorption contrast well beyond the optical diffusion limit. Conventional photoacoustic systems rely on externally delivered light and are therefore…

Optics · Physics 2026-01-06 David C. Garrett , Lihong V. Wang

Delay-and-Sum (DAS) beamformer is the most common beamforming algorithm in Photoacoustic imaging (PAI) due to its simple implementation and real time imaging. However, it provides poor resolution and high levels of sidelobe. A new algorithm…

Signal Processing · Electrical Eng. & Systems 2018-01-22 Moein Mozaffarzadeh , Ali Mahloojifar , Mahdi Orooji

In optoacoustic (photoacoustic) tomography, several parameters related to tissue and detector features are needed for image formation, but they may not be known a priori. An autofocus (AF) algorithm is generally used to estimate these…

Medical Physics · Physics 2022-03-14 Ludwig Englert , Lucas Riobo , Christine Schonemann , Vasilis Ntziachristos , Juan Aguirre
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