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We present a new approach for estimating parameters in rational ODE models from given (measured) time series data. In typical existing approaches, an initial guess for the parameter values is made from a given search interval. Then, in a…

Mathematical Software · Computer Science 2023-12-19 Oren Bassik , Yosef Berman , Soo Go , Hoon Hong , Ilia Ilmer , Alexey Ovchinnikov , Chris Rackauckas , Pedro Soto , Chee Yap

The abundance of modern health data provides many opportunities for the use of machine learning techniques to build better statistical models to improve clinical decision making. Predicting time-to-event distributions, also known as…

Machine Learning · Statistics 2020-12-15 Zidi Xiu , Chenyang Tao , Benjamin A. Goldstein , Ricardo Henao

We propose ODTE, a new ensemble that uses oblique decision trees as base classifiers. Additionally, we introduce STree, the base algorithm for growing oblique decision trees, which leverages support vector machines to define hyperplanes…

Machine Learning · Computer Science 2025-03-18 Ricardo Montañana , José A. Gámez , José M. Puerta

Tree-based models are increasingly popular due to their ability to identify complex relationships that are beyond the scope of parametric models. Survival tree methods adapt these models to allow for the analysis of censored outcomes, which…

Machine Learning · Computer Science 2020-12-09 Dimitris Bertsimas , Jack Dunn , Emma Gibson , Agni Orfanoudaki

Survival analysis is an essential tool for the study of health data. An inherent component of such data is the presence of missing values. In recent years, researchers proposed new learning algorithms for survival tasks based on neural…

Machine Learning · Statistics 2023-03-27 Paul Dufossé , Sébastien Benzekry

The neural Ordinary Differential Equation (ODE) model has shown success in learning complex continuous-time processes from observations on discrete time stamps. In this work, we consider the modeling and forecasting of time series data that…

Machine Learning · Statistics 2023-06-05 Yixuan Tan , Liyan Xie , Xiuyuan Cheng

Continuous-depth neural networks can be viewed as deep limits of discrete neural networks whose dynamics resemble a discretization of an ordinary differential equation (ODE). Although important steps have been taken to realize the…

Neural and Evolutionary Computing · Computer Science 2020-12-09 François-Xavier Vialard , Roland Kwitt , Susan Wei , Marc Niethammer

Deterministic flow models, such as rectified flows, offer a general framework for learning a deterministic transport map between two distributions, realized as the vector field for an ordinary differential equation (ODE). However, they are…

Machine Learning · Computer Science 2024-10-04 Saurabh Singh , Ian Fischer

Pharmacokinetic modeling using ordinary differential equations (ODEs) has an important role in dose optimization studies, where dosing must balance sustained therapeutic efficacy with the risk of adverse side effects. Such ODE models…

Methodology · Statistics 2025-06-30 Yuxuan Zhao , Samuel W. K. Wong

Model reduction for fluid flow simulation continues to be of great interest across a number of scientific and engineering fields. Here, we explore the use of Neural Ordinary Differential Equations, a recently introduced family of…

Machine Learning · Computer Science 2021-04-30 Sourav Dutta , Peter Rivera-Casillas , Matthew W. Farthing

Accurate models of patient survival probabilities provide important information to clinicians prescribing care for life-threatening and terminal ailments. A recently developed class of models - known as individual survival distributions…

Machine Learning · Computer Science 2019-06-27 Samuel Sokota , Ryan D'Orazio , Khurram Javed , Humza Haider , Russell Greiner

Background. Commonly, Deep Neural Networks (DNNs) generalize well on samples drawn from a distribution similar to that of the training set. However, DNNs' predictions are brittle and unreliable when the test samples are drawn from a…

Machine Learning · Computer Science 2022-04-01 Matan Haroush , Tzviel Frostig , Ruth Heller , Daniel Soudry

Deep Learning has emerged as one of the most significant innovations in machine learning. However, a notable limitation of this field lies in the ``black box" decision-making processes, which have led to skepticism within groups like…

Machine Learning · Computer Science 2025-03-06 Shi Li

The influx of deep learning (DL) techniques into the field of survival analysis in recent years has led to substantial methodological progress; for instance, learning from unstructured or high-dimensional data such as images, text or omics…

Machine Learning · Statistics 2024-02-23 Simon Wiegrebe , Philipp Kopper , Raphael Sonabend , Bernd Bischl , Andreas Bender

Increasing the layer number of on-chip photonic neural networks (PNNs) is essential to improve its model performance. However, the successively cascading of network hidden layers results in larger integrated photonic chip areas. To address…

Machine Learning · Computer Science 2023-02-08 Yun Zhao , Hang Chen , Min Lin , Haiou Zhang , Tao Yan , Xing Lin , Ruqi Huang , Qionghai Dai

This paper presents the Standalone Neural ODE (sNODE), a continuous-depth neural ODE model capable of describing a full deep neural network. This uses a novel nonlinear conjugate gradient (NCG) descent optimization scheme for training,…

Machine Learning · Computer Science 2022-06-09 Rym Jaroudi , Lukáš Malý , Gabriel Eilertsen , B. Tomas Johansson , Jonas Unger , George Baravdish

Ordinary differential equations (ODEs) describe dynamical systems evolving deterministically in continuous time. Accurate data-driven modeling of systems as ODEs, a central problem across the natural sciences, remains challenging,…

Machine Learning · Computer Science 2025-10-15 Maximilian Mauel , Manuel Hinz , Patrick Seifner , David Berghaus , Ramses J. Sanchez

A new (algebraic) approximation scheme to find {\sl global} solutions of two point boundary value problems of ordinary differential equations (ODE's) is presented. The method is applicable for both linear and nonlinear (coupled) ODE's whose…

High Energy Physics - Theory · Physics 2008-11-26 Bruno Boisseau , Peter Forgacs , Hector Giacomini

To be fully useful for public health practice, models for epidemic response must be able to do more than predict -- it is also important to incorporate the mechanisms underlying transmission dynamics to enable policymakers and practitioners…

Quantitative Methods · Quantitative Biology 2025-05-26 Jiale Tan , Marisa C. Eisenberg

Neural Ordinary Differential Equations (NODEs), a framework of continuous-depth neural networks, have been widely applied, showing exceptional efficacy in coping with representative datasets. Recently, an augmented framework has been…

Machine Learning · Computer Science 2023-04-12 Qunxi Zhu , Yao Guo , Wei Lin
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