Related papers: A control theory approach to optimal pandemic miti…
At the time of writing, the ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had already resulted in more than thirty-two million cases infected and more than one million deaths worldwide.…
Motivated by the swift global transmission of infectious diseases, we present a comprehensive framework for network-based epidemic control. Our aim is to curb epidemics using two different approaches. In the first approach, we introduce an…
The Susceptible-Infectious-Recovered (SIR) model is the canonical model of epidemics of infections that make people immune upon recovery. Many of the open questions in computational epidemiology concern the underlying contact structure's…
We investigate final outcome properties of an SIR (susceptible $\to$ infective $\to$ recovered) epidemic model defined on a population of large sub-communities in which there is stronger disease transmission within the communities than…
Mitigation measures are essential for controlling the spread of infectious diseases during pandemics and epidemics, but they impose considerable societal, individual, and economic costs. We developed a general optimization framework to…
We propose and solve an optimal vaccination problem within a deterministic compartmental model of SIRS type: the immunized population can become susceptible again, e.g.\ because of a not complete immunization power of the vaccine. A social…
We study the critical effect of an intermittent social distancing strategy on the propagation of epidemics in adaptive complex networks. We characterize the effect of our strategy in the framework of the susceptible-infected-recovered…
This article considers the minimization of the total number of infected individuals over the course of an epidemic in which the rate of infectious contacts can be reduced by time-dependent nonpharmaceutical interventions. The societal and…
Stochastic models are widely used to investigate the spread of epidemics in a complex environment. This paper extends a deterministic SAIRS epidemic model to a stochastic case with limited patient capacity and exposure. We first study the…
Research in epidemiology often focusses on designing interventions that result in the number of infected individuals asymptotically approaching zero, without considering that this number may peak at high values during transients. Recent…
In this paper, we have studied epidemiological models for Ebola infection using nonlinear ordinary differential equations and optimal control theory. We considered optimal control analysis of SIR and SEIR models for the deadly Ebola…
A model of reactive social distancing in epidemics is proposed, in which the infection rate changes with the number infected. The final-size equation for the total number that the epidemic will infect can be derived analytically, as can the…
We present a new mathematical model to explicitly capture the effects that the three restriction measures: the lockdown date and duration, social distancing and masks, and, schools and border closing, have in controlling the spread of…
In the context of SARS-CoV-2 pandemic, mathematical modelling has played a fundamental role for making forecasts, simulating scenarios and evaluating the impact of preventive political, social and pharmaceutical measures. Optimal control…
The Susceptible-Infected-Recovered (SIR) model has successfully mimicked the propagation of such airborne diseases as influenza A (H1N1). Although the SIR model has recently been studied in a multilayer networks configuration, in almost all…
Case isolation, that is, detection and isolation of infected individuals in order to prevent spread, is a strategy to curb infectious disease epidemics. Here, we study the efficiency of a case isolation strategy subject to time delays in…
As the world fights to contain and control the spread of the Novel Coronavirus, countries are imposing severe measures from restrictions on travel and social gatherings to complete lockdowns. Lockdowns, though effective in controlling the…
We propose a network behavioral-feedback Susceptible-Infected-Recovered (SIR) epidemic model in which the interaction matrix describing the infection rates across subpopulations depends in feedback on the current epidemic state. This model…
In this work we present a mathematical model that integrates the epidemiological dynamics of a vector-borne disease (SIR-SI) with Lotka Volterra predator prey ecological interactions. The study analyzes how the presence of natural predators…
Contagious diseases can spread quickly in human populations, either through airborne transmission or if some other spreading vectors are abundantly accessible. They can be particularly devastating if the impact on individuals' health has…