Related papers: Effects of nerve bundle geometry on neurotrauma ev…
Objective: Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the…
The aim was to investigate mechanical and functional failure of diffuse axonal injury (DAI) in nerve bundles following frontal head impacts, by finite element simulations. Anatomical changes following traumatic brain injury are simulated at…
In this study we give a geometrical model which employs the smoothness of nerve fibers as differentiable curves. We show that a nerve fiber may encounter large curvature due to the possible helicial bending and hence it could cause the…
We study the damage process of fiber bundles in a wedge-shape geometry which ensures a constant strain gradient. To obtain the wedge geometry we consider the three-point bending of a bar, which is modelled as two rigid blocks glued together…
Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of…
This paper attempts to review our studies on the propagation of signals in nerves over the past decade. The need for interdisciplinary studies is stressed that helps to understand the physical mechanisms of coupling the electrical,…
In comparative and developmental neuroanatomy one encounters questions regarding the deformation of neural tissue under stress. The motivation of this note is an observation (Barbas {\it et al}) that at cortical folds or gyri, the layers of…
Recent investigations of traumatic brain injuries have shown that these injuries can result in conformational changes at the level of individual neurons in the cerebral cortex. Focal axonal swelling is one consequence of such injuries and…
In this work I have studied the effect of disorder and system size in fiber bundle model with a certain range of stress redistribution. The strength of the bundle as well as the failure abruptness is observed with varying disorder, stress…
We develop the theory of the coupling between in-plane order and out-of-plane geometry in twisted, two-dimensionally ordered filament bundles based on the non-linear continuum elasticity theory of columnar materials. We show that twisted…
Topological defects are crucial to the thermodynamics and structure of condensed matter systems. For instance, when incorporated into crystalline membranes like graphene, disclinations with positive and negative topological charge…
Cellular elastomeric metamaterials are interesting for various applications, e.g. soft robotics, as they may exhibit multiple microstructural pattern transformations, each with its characteristic mechanical behavior. Numerical literature…
Many of the recent remarkable advances in computer vision and language models can be attributed to the success of transfer learning via the pre-training of large foundation models. However, a theoretical framework which explains this…
3D mesh segmentation is an important task with many biomedical applications. The human body has bilateral symmetry and some variations in organ positions. It allows us to expect a positive effect of rotation and inversion invariant layers…
We explore the robustness of complex networks against physical damage. We focus on spatially embedded network models and datasets where links are physical objects or physically transfer some quantity, which can be disrupted at any point…
Bundles of filaments are subject to geometric frustration: certain deformations (e.g. bending while twisted) require longitudinal variations in spacing between filaments. While bundles are common -- from protein fibers to yarns -- the…
Disordered solids often change their elastic response as they slowly age. Using experiments and simulations, we study how aging disordered planar networks under an applied stress affects their nonlinear elastic response. We are able to…
The deformation of brittle material is primarily accompanied by micro-cracking and faulting. However, it has often been found that continuum fluid models, usually based on a non-Newtonian viscosity, are applicable. To explain this rheology,…
New cells are generated throughout life and integrate into the hippocampus via the process of adult neurogenesis. Epileptogenic brain injury induces many structural changes in the hippocampus, including the death of interneurons and altered…
A phase diagram for a one dimensional fiber bundle model is constructed with a continuous variation in two parameters guiding dynamics of the model: strength of disorder and system size. We monitor the successive events of fiber rupture in…