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A phase-field model for dealing with dynamic instabilities in membranes is presented. We use it to study curvature-driven pearling instability in vesicles induced by the anchorage of amphiphilic polymers on the membrane. Within this model,…

Quantitative Methods · Quantitative Biology 2011-11-10 F. Campelo , A. Hernandez-Machado

Besides direct molecular interactions, proteins and nanoparticles embedded in or adsorbed to membranes experience indirect interactions that are mediated by the membranes. These membrane-mediated interactions arise from the membrane…

Soft Condensed Matter · Physics 2024-07-08 Francesco Bonazzi , Thomas R. Weikl

The mechanical effects of membrane compositional inhomogeneities are analyzed in a process analogous of neck formation in cellular membranes. We cast on the Canham-Helfrich model of fluid membranes with both the spontaneous curvature and…

Soft Condensed Matter · Physics 2022-03-30 G. Torres-Vargas , F. Monroy , J. A. Santiago

A tethered vesicle, which consists of a cylindrical membrane tube and a spherical vesicle, is produced by a mechanical force that is experimentally imposed by optical tweezers and a micropipette. This tethered vesicle is employed for…

Soft Condensed Matter · Physics 2021-12-30 Hiroshi Noguchi

Biomembranes wrapping cells and organelles are not only the partitions that separate the insides but also dynamic fields for biological functions accompanied by membrane shape changes. In this review, we discuss the spatiotemporal patterns…

Soft Condensed Matter · Physics 2025-01-22 Hiroshi Noguchi

Phagocytosis is the fundamental cellular process by which eukaryotic cells bind and engulf particles by their cell membrane. Particle engulfment involves particle recognition by cell-surface receptors, signaling and remodeling of the actin…

Cell Behavior · Quantitative Biology 2010-11-02 Sylvain Tollis , Anna E. Dart , George Tzircotis , Robert G. Endres

We study the kinematics and dynamics of a highly compliant membrane disk placed head-on in a uniform flow. With increasing flow velocity, the membrane deforms nonlinearly into increasingly parachute-like shapes. These aerodynamically…

Fluid Dynamics · Physics 2023-09-11 Varghese Mathai , Asimanshu Das , Dante L. Naylor , Kenneth S. Breuer

By adjusting the interface energy, curvature, and velocity, the anisotropy plays an important role in the interaction between interfacial processes and transport processes, determining the solidification structures. In this paper, through…

Materials Science · Physics 2022-10-31 Fengyi Yu

Cellular membranes are a heterogeneous mix of lipids, proteins and small molecules. Special groupings of saturated lipids and cholesterol form a liquid-ordered phase, known as `lipid rafts,' serving as platforms for signaling, trafficking…

Quantitative Methods · Quantitative Biology 2015-05-13 Tristan S. Ursell , William S. Klug , Rob Phillips

We present a novel Monte Carlo simulation of the phase separation dynamics of a model fluid membrane. Such a phase segregation induces shape changes of the membrane and results in local `budding' under favourable conditions. We present a…

Condensed Matter · Physics 2007-05-23 P. B. Sunil Kumar , Madan Rao

The shape transformations of fluid membranes induced by curved protein rods are studied using meshless membrane simulations. The rod assembly at low rod density induces a flat membrane tube and oblate vesicle. It is found that the…

Soft Condensed Matter · Physics 2015-09-30 Hiroshi Noguchi

We formulate a model for the dynamic growth of a membrane developing in a flow as the result of a precipitation reaction, a situation inspired by recent microfluidic experiments. The precipitating solid introduces additional forces on the…

Fluid Dynamics · Physics 2020-03-18 P. S. Eastham , M. N. J. Moore , N. G. Cogan , Q. Wang , O. Steinbock

We found that the order for the crumpling transition of an intrinsic curvature model changes depending on the distance between two boundary vertices fixed on the surface of spherical topology. The model is a curvature one governed by an…

Statistical Mechanics · Physics 2007-05-23 H. Koibuchi

Uncovering the rules governing the nonequilibrium dynamics of the membranes that define biological cells is of central importance to understanding the physics of living systems. We theoretically and computationally investigate the behavior…

Cholesterol plays an essential role in biological membranes and is crucial for maintaining their stability and functionality. It is necessary for a variety of membranes, including planar bilayers, liposomes, curved bilayers, nanodiscs, and…

Biomolecules · Quantitative Biology 2025-04-09 Ehsaneh Khodadadi , Ehsan Khodadadi , Parth Chaturvedi , Mahmoud Moradi

We study the stability and shapes of domains with spontaneous curvature in fluid films and membranes, embedded in a surrounding membrane with zero spontaneous curvature. These domains can result from the inclusion of an impurity in a fluid…

Soft Condensed Matter · Physics 2009-11-11 James L. Harden , Fred C. MacKintosh , Peter D. Olmsted

How pattern and form are generated in a reproducible manner during embryogenesis remains poorly understood. Intestinal organoid morphogenesis involves a number of mechanochemical regulators, including cell-type specific cytoskeletal forces…

Tissues and Organs · Quantitative Biology 2024-04-01 Shi-Lei Xue , Qiutan Yang , Prisca Liberali , Edouard Hannezo

Many cellular organelles are membrane-bound structures with complex membrane composition and shape. Their shapes have been observed to depend on the metabolic state of the organelle, and the mechanisms that couple biochemical pathways and…

Soft Condensed Matter · Physics 2023-07-19 Toni V. Mendes , Jonas Ranft , Hélène Berthoumieux

A coarse-grained computational model is used to investigate the effect of a fluctuating fluid membrane on the dynamics of patchy-particle assembly into virus capsid-like cores. Results from simulations for a broad range of parameters are…

Soft Condensed Matter · Physics 2014-11-18 Richard Matthews , Christos N. Likos

We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. Self-assembly of protein domains by electrostatic lipid-protein interactions is contrasted with self-organization due to…

Cell Behavior · Quantitative Biology 2007-05-23 Karin John , Markus Baer
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