Related papers: Mechanical characterization of brain tissue in sim…
Mechanical characterization of brain tissue at high loading velocities is crucial for modeling Traumatic Brain Injury (TBI). During severe impact conditions, brain tissue experiences compression, tension and shear. Limited experimental data…
The mechanical characterization of brain tissue at high loading velocities is vital for understanding and modeling Traumatic Brain Injury (TBI). The most severe form of TBI is diffuse axonal injury (DAI) which involves damage to individual…
Traumatic brain injury (TBI) occurs when local mechanical load exceeds certain tolerance levels for brain tissue. Extensive research has been done previously for brain matter experiencing compression at quasistatic loading; however, limited…
Mechanical characterization of brain tissue has been investigated extensively by various research groups over the past fifty years. These properties are particularly important for modelling Traumatic Brain Injury (TBI). In this research, we…
Brain tissue accommodates non-linear deformations and exhibits time-dependent mechanical behaviour. The latter is one of the most pronounced features of brain tissue, manifesting itself primarily through viscoelastic effects such as stress…
The brain-skull interface (meninges) plays a critical role in governing brain motion during head impacts, yet computational models often simplify this interface using idealized contact conditions due to limited experimental data. This study…
We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves…
We show that porcine brain matter can be modelled accurately as a very soft rubber-like material using the Mooney-Rivlin strain energy function, up to strains as high as 60\%. This result followed from simple shear experiments performed on…
Objective: Many recent studies have suggested that brain deformation resulting from a head impact is linked to the corresponding clinical outcome, such as mild traumatic brain injury (mTBI). Even though several finite element (FE) head…
Shear shocks, which exist in a completely different regime from compressional shocks, were recently observed in the brain. These low phase speed ($\approx$ 2 m/s) high Mach number ($\approx$ 1) waves could be the primary mechanism behind…
Using high frame-rate ultrasound and high sensitivity motion tracking, we recently showed that shear waves sent to the ex vivo porcine brain develop into shear shock waves with destructive local accelerations inside the brain which may be a…
The internal deformation of the brain is far more complex than the rigid motion of the skull. An ultrasound imaging technique that we have developed has a combination of penetration, frame-rate, and motion detection accuracy required to…
Extensive research has been carried out for at least 50 years to understand the mechanical properties of brain tissue in order to understand the mechanisms of traumatic brain injury (TBI). The observed large variability in experimental…
Mechanical stresses in soft materials across different length scales play a fundamental role in understanding the function of biological systems and in the use of artificial materials for engineering soft machines and biomedical devices.…
Understanding the mechanical behavior of brain tissue is crucial for advancing both fundamental neuroscience and clinical applications. Yet, accurately measuring these properties remains challenging due to the brain unique mechanical…
Experiments test the dependence of shearing stress on the first two gradients of shear strain. The tests were conducted by direct numerical simulation using the Discrete Element Method (DEM) on a large two-dimensional (2D) assembly of…
Finite Element simulations of rubbers and biological soft tissue usually assume that the material being deformed is slightly compressible. It is shown here that in shearing deformations the corresponding normal stress distribution can…
Traumatic brain injury (TBI) is a complex injury that is hard to predict and diagnose, with many studies focused on associating head kinematics to brain injury risk. Recently, there has been a push towards using computationally expensive…
Computational biomechanics models of the brain have become an important tool for investigating the brain responses to mechanical loads. The geometry, loading conditions, and constitutive properties of such brain models are well-studied and…
Mechanical stress within biological tissue can indicate an anomaly, or can be vital of its function, such as stresses in arteries. Measuring these stresses in tissue is challenging due to the complex, and often unknown, nature of the…