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Diversity plays a vital role in many text generating applications. In recent years, Conditional Variational Auto Encoders (CVAE) have shown promising performances for this task. However, they often encounter the so called KL-Vanishing…

Machine Learning · Statistics 2019-03-27 Yuchi Zhang , Yongliang Wang , Liping Zhang , Zhiqiang Zhang , Kun Gai

We note that most existing approaches for molecular graph generation fail to guarantee the intrinsic property of permutation invariance, resulting in unexpected bias in generative models. In this work, we propose GraphEBM to generate…

Machine Learning · Computer Science 2021-04-13 Meng Liu , Keqiang Yan , Bora Oztekin , Shuiwang Ji

The cosmic microwave background power spectra are a primary window into the early universe. However, achieving interpretable, likelihood-compatible compression and fast inference under weak model assumptions remains challenging. We propose…

Cosmology and Nongalactic Astrophysics · Physics 2025-11-03 Tian-Yang Sun , Tian-Nuo Li , He Wang , Jing-Fei Zhang , Xin Zhang

With the recent advances in machine learning for quantum chemistry, it is now possible to predict the chemical properties of compounds and to generate novel molecules. Existing generative models mostly use a string- or graph-based…

Biomolecules · Quantitative Biology 2020-10-14 Vitali Nesterov , Mario Wieser , Volker Roth

Graph autoencoders (AE) and variational autoencoders (VAE) recently emerged as powerful node embedding methods, with promising performances on challenging tasks such as link prediction and node clustering. Graph AE, VAE and most of their…

Machine Learning · Computer Science 2019-10-03 Guillaume Salha , Romain Hennequin , Michalis Vazirgiannis

Generating novel graph structures that optimize given objectives while obeying some given underlying rules is fundamental for chemistry, biology and social science research. This is especially important in the task of molecular graph…

Machine Learning · Computer Science 2019-02-26 Jiaxuan You , Bowen Liu , Rex Ying , Vijay Pande , Jure Leskovec

We present a new supervised learning technique for the Variational AutoEncoder (VAE) that allows it to learn a causally disentangled representation and generate causally disentangled outcomes simultaneously. We call this approach Causally…

Machine Learning · Statistics 2023-10-10 Seunghwan An , Kyungwoo Song , Jong-June Jeon

Graph representation learning is a fundamental research issue in various domains of applications, of which the inductive learning problem is particularly challenging as it requires models to generalize to unseen graph structures during…

Machine Learning · Computer Science 2024-03-27 Hanxuan Yang , Zhaoxin Yu , Qingchao Kong , Wei Liu , Wenji Mao

This paper proposes a convolutional neural network that can fuse high-level prior for semantic image segmentation. Motivated by humans' vision recognition system, our key design is a three-layer generative structure consisting of high-level…

Computer Vision and Pattern Recognition · Computer Science 2015-11-24 Haitian Zheng , Yebin Liu , Mengqi Ji , Feng Wu , Lu Fang

We present a conditional variational auto-encoder (VAE) which, to avoid the substantial cost of training from scratch, uses an architecture and training objective capable of leveraging a foundation model in the form of a pretrained…

Computer Vision and Pattern Recognition · Computer Science 2022-05-31 William Harvey , Saeid Naderiparizi , Frank Wood

We propose a molecular generative model based on the conditional variational autoencoder for de novo molecular design. It is specialized to control multiple molecular properties simultaneously by imposing them on a latent space. As a proof…

Machine Learning · Computer Science 2018-06-18 Jaechang Lim , Seongok Ryu , Jin Woo Kim , Woo Youn Kim

Variational autoencoders (VAEs) have been used in prior works for generating and blending levels from different games. To add controllability to these models, conditional VAEs (CVAEs) were recently shown capable of generating output that…

Machine Learning · Computer Science 2021-06-25 Anurag Sarkar , Seth Cooper

Variational autoencoders (VAEs) are powerful generative models with the salient ability to perform inference. Here, we introduce a quantum variational autoencoder (QVAE): a VAE whose latent generative process is implemented as a quantum…

Learning distributions of graphs can be used for automatic drug discovery, molecular design, complex network analysis, and much more. We present an improved framework for learning generative models of graphs based on the idea of deep state…

Machine Learning · Computer Science 2021-12-07 Julian Stier , Michael Granitzer

Deep learning has significantly advanced and accelerated de novo molecular generation. Generative networks, namely Variational Autoencoders (VAEs) can not only randomly generate new molecules, but also alter molecular structures to optimize…

Biomolecules · Quantitative Biology 2022-05-04 Ryan J Richards , Austen M Groener

Variational Auto-Encoders (VAEs) are capable of learning latent representations for high dimensional data. However, due to the i.i.d. assumption, VAEs only optimize the singleton variational distributions and fail to account for the…

Machine Learning · Computer Science 2020-04-20 Da Tang , Dawen Liang , Tony Jebara , Nicholas Ruozzi

With the development of graph applications, generative models for graphs have been more crucial. Classically, stochastic models that generate graphs with a pre-defined probability of edges and nodes have been studied. Recently, some models…

Machine Learning · Computer Science 2023-04-07 Shohei Nakazawa , Yoshiki Sato , Kenji Nakagawa , Sho Tsugawa , Kohei Watabe

A molecule's geometry, also known as conformation, is one of a molecule's most important properties, determining the reactions it participates in, the bonds it forms, and the interactions it has with other molecules. Conventional…

Machine Learning · Computer Science 2020-01-01 Elman Mansimov , Omar Mahmood , Seokho Kang , Kyunghyun Cho

Coarse-grained (CG) molecular dynamics (MD) simulations can simulate large molecular complexes over extended timescales by reducing degrees of freedom. A critical step in CG modeling is the selection of the CG mapping algorithm, which…

Soft Condensed Matter · Physics 2025-07-23 Soumya Mondal , Subhanu Halder , Debarchan Basu , Sandeep Kumar , Tarak Karmakar

We propose the Graph Context Encoder (GCE), a simple but efficient approach for graph representation learning based on graph feature masking and reconstruction. GCE models are trained to efficiently reconstruct input graphs similarly to a…

Machine Learning · Computer Science 2021-06-21 Oriel Frigo , Rémy Brossard , David Dehaene
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