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One of the fundamental challenges in supervised learning for multimodal image registration is the lack of ground-truth for voxel-level spatial correspondence. This work describes a method to infer voxel-level transformation from…

Brain tissue segmentation is essential for neuroscience and clinical studies. However, segmentation on longitudinal data is challenging due to dynamic brain changes across the lifespan. Previous researches mainly focus on self-supervision…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Yongheng Sun , Fan Wang , Jun Shu , Haifeng Wang , Li Wang. Deyu Meng , Chunfeng Lian

In this work, we propose a new paradigm of iterative model-based reconstruction algorithms for providing real-time solution for zooming-in and refining a region of interest in medical and clinical tomographic images. This algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Junqi Tang , Guixian Xu , Jinglai Li

Neural network-based approaches can achieve high accuracy in various medical image segmentation tasks. However, they generally require large labelled datasets for supervised learning. Acquiring and manually labelling a large medical dataset…

Image and Video Processing · Electrical Eng. & Systems 2020-06-25 Chen Chen , Chen Qin , Huaqi Qiu , Cheng Ouyang , Shuo Wang , Liang Chen , Giacomo Tarroni , Wenjia Bai , Daniel Rueckert

Clinically significant prostate cancer has a better chance to be sampled during ultrasound-guided biopsy procedures, if suspected lesions found in pre-operative magnetic resonance (MR) images are used as targets. However, the diagnostic…

Machine Learning · Computer Science 2022-07-25 Iani JMB Gayo , Shaheer U. Saeed , Dean C. Barratt , Matthew J. Clarkson , Yipeng Hu

Prostate cancer diagnosis through MR imaging have currently relied on radiologists' interpretation, whilst modern AI-based methods have been developed to detect clinically significant cancers independent of radiologists. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2026-01-09 Xiangcen Wu , Yipei Wang , Qianye Yang , Natasha Thorley , Shonit Punwani , Veeru Kasivisvanathan , Ester Bonmati , Yipeng Hu

Longitudinal analysis has great potential to reveal developmental trajectories and monitor disease progression in medical imaging. This process relies on consistent and robust joint 4D segmentation. Traditional techniques are dependent on…

Machine Learning · Computer Science 2019-06-19 Malav Bateriwala , Pierrick Bourgeat

A standard treatment protocol for breast cancer entails administering neoadjuvant therapy followed by surgical removal of the tumor and surrounding tissue. Pathologists typically rely on cabinet X-ray radiographs, known as Faxitron, to…

Image and Video Processing · Electrical Eng. & Systems 2024-01-19 Negar Golestani , Aihui Wang , Gregory R Bean , Mirabela Rusu

Image registration is an ill-posed inverse problem which often requires regularisation on the solution space. In contrast to most of the current approaches which impose explicit regularisation terms such as smoothness, in this paper we…

Image and Video Processing · Electrical Eng. & Systems 2020-07-09 Chen Qin , Shuo Wang , Chen Chen , Huaqi Qiu , Wenjia Bai , Daniel Rueckert

Deep learning has been widely used to analyze digitized hematoxylin and eosin (H&E)-stained histopathology whole slide images. Automated cancer segmentation using deep learning can be used to diagnose malignancy and to find novel…

Image and Video Processing · Electrical Eng. & Systems 2022-03-30 David Joon Ho , M. Herman Chui , Chad M. Vanderbilt , Jiwon Jung , Mark E. Robson , Chan-Sik Park , Jin Roh , Thomas J. Fuchs

With the wealth of medical image data, efficient curation is essential. Assigning the sequence type to magnetic resonance images is necessary for scientific studies and artificial intelligence-based analysis. However, incomplete or missing…

Image and Video Processing · Electrical Eng. & Systems 2024-08-01 Deepa Krishnaswamy , Bálint Kovács , Stefan Denner , Steve Pieper , David Clunie , Christopher P. Bridge , Tina Kapur , Klaus H. Maier-Hein , Andrey Fedorov

Image segmentation and registration are said to be challenging when applied to dynamic contrast enhanced MRI sequences (DCE-MRI). The contrast agent causes rapid changes in intensity in the region of interest and elsewhere, which can lead…

Image and Video Processing · Electrical Eng. & Systems 2023-06-23 Adam G. Tattersall , Keith A. Goatman , Lucy E. Kershaw , Scott I. K. Semple , Sonia Dahdouh

Multi-contrast image registration is a challenging task due to the complex intensity relationships between different imaging contrasts. Conventional image registration methods are typically based on iterative optimizations for each input…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Yinsong Wang , Siyi Du , Shaoming Zheng , Xinzhe Luo , Chen Qin

Spatially varying regularization accommodates the deformation variations that may be necessary for different anatomical regions during deformable image registration. Historically, optimization-based registration models have harnessed…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Junyu Chen , Shuwen Wei , Yihao Liu , Zhangxing Bian , Yufan He , Aaron Carass , Harrison Bai , Yong Du

Registration of images with pathologies is challenging due to tissue appearance changes and missing correspondences caused by the pathologies. Moreover, mass effects as observed for brain tumors may displace tissue, creating larger…

Image and Video Processing · Electrical Eng. & Systems 2020-08-19 Xu Han , Zhengyang Shen , Zhenlin Xu , Spyridon Bakas , Hamed Akbari , Michel Bilello , Christos Davatzikos , Marc Niethammer

Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Pawel Mlynarski , Hervé Delingette , Antonio Criminisi , Nicholas Ayache

The automatic analysis of subtle changes between longitudinal MR images is an important task as it is still a challenging issue in scope of the breast medical image processing. In this paper we propose an effective automatic change…

Image and Video Processing · Electrical Eng. & Systems 2021-10-22 Narges Norouzi , Reza Azmi , Nooshin Noshiri , Robab Anbiaee

Diffeomorphic image registration (DIR) is a fundamental task in 3D medical image analysis that seeks topology-preserving deformations between image pairs. To ensure diffeomorphism, a common approach is to model the deformation field as the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Mohammadjavad Matinkia , Nilanjan Ray

We present deformable unsupervised medical image registration using a randomly-initialized deep convolutional neural network (CNN) as regularization prior. Conventional registration methods predict a transformation by minimizing…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Max-Heinrich Laves , Sontje Ihler , Tobias Ortmaier

Registration is a fundamental task in medical image analysis which can be applied to several tasks including image segmentation, intra-operative tracking, multi-modal image alignment, and motion analysis. Popular registration tools such as…

Computer Vision and Pattern Recognition · Computer Science 2019-10-07 Wentao Zhu , Andriy Myronenko , Ziyue Xu , Wenqi Li , Holger Roth , Yufang Huang , Fausto Milletari , Daguang Xu