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The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age", which can be compared to an age norm to reflect the deviation from normal aging process. Here, we develop…

Determining if the brain is developing normally is a key component of pediatric neuroradiology and neurology. Brain magnetic resonance imaging (MRI) of infants demonstrates a specific pattern of development beyond simply myelination. While…

Image and Video Processing · Electrical Eng. & Systems 2021-12-28 Mahdieh Shabanian , Markus Wenzel , John P. DeVincenzo

Predicting future brain state from a baseline magnetic resonance image (MRI) is a central challenge in neuroimaging and has important implications for studying neurodegenerative diseases such as Alzheimer's disease (AD). Most existing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Ali Farki , Elaheh Moradi , Deepika Koundal , Jussi Tohka

Brain age prediction using neuroimaging data has shown great potential as an indicator of overall brain health and successful aging, as well as a disease biomarker. Deep learning models have been established as reliable and efficient brain…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Bruno Machado Pacheco , Victor Hugo Rocha de Oliveira , Augusto Braga Fernandes Antunes , Saulo Domingos de Souza Pedro , Danilo Silva

Deep learning techniques have demonstrated great potential for accurately estimating brain age by analyzing Magnetic Resonance Imaging (MRI) data from healthy individuals. However, current methods for brain age estimation often directly…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Fanzhe Yan , Gang Yang , Yu Li , Aiping Liu , Xun Chen

Brain age prediction based on neuroimaging data could help characterize both the typical brain development and neuropsychiatric disorders. Pattern recognition models built upon functional connectivity (FC) measures derived from resting…

Computer Vision and Pattern Recognition · Computer Science 2018-01-15 Hongming Li , Theodore D. Satterthwaite , Yong Fan

Brain aging, and more specifically the difference between the chronological and the biological age of a person, may be a promising biomarker for identifying neurodegenerative diseases. For this purpose accurate prediction is important but…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Alexander Hammers , Daniel Rueckert

In computational neuroscience, there has been an increased interest in developing machine learning algorithms that leverage brain imaging data to provide estimates of "brain age" for an individual. Importantly, the discordance between brain…

Quantitative Methods · Quantitative Biology 2023-10-30 Saurabh Sihag , Gonzalo Mateos , Corey McMillan , Alejandro Ribeiro

Brain age estimation based on magnetic resonance imaging (MRI) is an active research area in early diagnosis of some neurodegenerative diseases (e.g. Alzheimer, Parkinson, Huntington, etc.) for elderly people or brain underdevelopment for…

Image and Video Processing · Electrical Eng. & Systems 2021-08-04 Ruizhe Li , Matteo Bastiani , Dorothee Auer , Christian Wagner , Xin Chen

Human brain development is rapid during infancy and early childhood. Many disease processes impair this development. Therefore, brain developmental age estimation (BDAE) is essential for all diseases affecting cognitive development. Brain…

Image and Video Processing · Electrical Eng. & Systems 2019-11-06 Mahdieh Shabanian , Eugene C. Eckstein , Hao Chen , John P. DeVincenzo

Neurodegeneration, characterized by the progressive loss of neuronal structure or function, is commonly assessed in clinical practice through reductions in cortical thickness or brain volume, as visualized by structural MRI. While…

Signal Processing · Electrical Eng. & Systems 2025-10-15 Saurabh Sihag , Gonzalo Mateos , Alejandro Ribeiro

The accurate quantification of brain age from MRI has emerged as an important biomarker of brain health. However, existing approaches are often restricted to narrow age ranges and single-modality MRI data, limiting their capacity to capture…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Dingyi Zhang , Ruiying Liu , Yun Wang

The identification of Alzheimer's disease (AD) and its early stages using structural magnetic resonance imaging (MRI) has been attracting the attention of researchers. Various data-driven approaches have been introduced to capture subtle…

Artificial Intelligence · Computer Science 2021-08-11 Changhyun Park , Heung-Il Suk

Age is one of the major known risk factors for Alzheimer's Disease (AD). Detecting AD early is crucial for effective treatment and preventing irreversible brain damage. Brain age, a measure derived from brain imaging reflecting structural…

Image and Video Processing · Electrical Eng. & Systems 2024-05-07 Jay Shah , Md Mahfuzur Rahman Siddiquee , Yi Su , Teresa Wu , Baoxin Li

Brain aging is a complex and dynamic process, leading to functional and structural changes in the brain. These changes could lead to the increased risk of neurodegenerative diseases and cognitive decline. Accurate brain-age estimation…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Saadat Behzadi , Danial Sharifrazi , Roohallah Alizadehsani , Mojtaba Lotfaliany , Mohammadreza Mohebbi

Analyzing and predicting brain aging is essential for early prognosis and accurate diagnosis of cognitive diseases. The technique of neuroimaging, such as Magnetic Resonance Imaging (MRI), provides a noninvasive means of observing the aging…

Image and Video Processing · Electrical Eng. & Systems 2022-12-06 Jingru Fu , Antonios Tzortzakakis , José Barroso , Eric Westman , Daniel Ferreira , Rodrigo Moreno

Brain aging is a regional phenomenon, a facet that remains relatively under-explored within the realm of brain age prediction research using machine learning methods. Voxel-level predictions can provide localized brain age estimates that…

Computer Vision and Pattern Recognition · Computer Science 2024-04-26 Neha Gianchandani , Mahsa Dibaji , Johanna Ospel , Fernando Vega , Mariana Bento , M. Ethan MacDonald , Roberto Souza

Structural magnetic resonance imaging (sMRI) can identify subtle brain changes due to its high contrast for soft tissues and high spatial resolution. It has been widely used in diagnosing neurological brain diseases, such as Alzheimer…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Xin Zhang , Liangxiu Han , Lianghao Han , Haoming Chen , Darren Dancey , Daoqiang Zhang

We propose an interpretable 3D Grid-Attention deep neural network that can accurately predict a person's age and whether they have Alzheimer's disease (AD) from a structural brain MRI scan. Building on a 3D convolutional neural network, we…

Tissues and Organs · Quantitative Biology 2020-11-19 Pradeep Lam , Alyssa H. Zhu , Iyad Ba Gari , Neda Jahanshad , Paul M. Thompson

Deep learning algorithms for predicting neuroimaging data have shown considerable promise in various applications. Prior work has demonstrated that deep learning models that take advantage of the data's 3D structure can outperform standard…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Yuda Bi , Anees Abrol , Zening Fu , Jiayu Chen , Jingyu Liu , Vince Calhoun