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Determining the interaction partners among protein/domain families poses hard computational problems, in particular in the presence of paralogous proteins. Available approaches aim to identify interaction partners among protein/domain…

Populations and Evolution · Quantitative Biology 2015-01-14 Iman Hajirasouliha , Alexander Schönhuth , David Juan , Alfonso Valencia , S. Cenk Sahinalp

Many methods have been developed for finding the commonalities between different organisms to study their phylogeny. The structure of metabolic networks also reveal valuable insights into metabolic capacity of species as well as into the…

Molecular Networks · Quantitative Biology 2016-04-08 Krishanu Deyasi , Anirban Banerjee , Bony Deb

We introduce a new class of tree-based models, P-Trees, for analyzing (unbalanced) panel of individual asset returns, generalizing high-dimensional sorting with economic guidance and interpretability. Under the mean-variance efficient…

Machine Learning · Computer Science 2025-02-05 Lin William Cong , Guanhao Feng , Jingyu He , Xin He

Fixed tree topologies are widely used in phylodynamic analyses to reduce computational burden, yet the consequences of this assumption remain insufficiently understood. Here, we systematically assess the impact of various fixed-topology…

Populations and Evolution · Quantitative Biology 2025-12-01 Mathieu Fourment , Jiansi Gao , Marc A Suchard , Frederick A Matsen

Classification of gene trees is an important task both in the analysis of multi-locus phylogenetic data, and assessment of the convergence of Markov Chain Monte Carlo (MCMC) analyses used in Bayesian phylogenetic tree reconstruction. The…

Combinatorics · Mathematics 2024-06-10 Georgios Aliatimis , Ruriko Yoshida , Burak Boyaci , James A. Grant

The statistical estimation of phylogenies is always associated with uncertainty, and accommodating this uncertainty is an important component of modern phylogenetic comparative analysis. The birth-death polytomy resolver is a method of…

Quantitative Methods · Quantitative Biology 2015-03-18 Daniel L. Rabosky

Randomized experiments have been critical tools of decision making for decades. However, subjects can show significant heterogeneity in response to treatments in many important applications. Therefore it is not enough to simply know which…

Machine Learning · Computer Science 2017-09-13 Yan Zhao , Xiao Fang , David Simchi-Levi

In this work we study the limit distribution of an appropriately normalized cophenetic index of the pure-birth tree conditioned on $n$ contemporary tips. We show that this normalized phylogenetic balance index is a submartingale that…

Populations and Evolution · Quantitative Biology 2020-11-23 Krzysztof Bartoszek

We derive tractable criteria for the consistency of Bayesian tree reconstruction procedures, which constitute a central class of algorithms for inferring common ancestry among DNA sequence samples in phylogenetics. Our results encompass…

Statistics Theory · Mathematics 2025-08-05 Alisa Kirichenko , Luke J. Kelly , Jere Koskela

Compatibility of unrooted phylogenetic trees is a well studied problem in phylogenetics. It asks to determine whether for a set of k input trees there exists a larger tree (called a supertree) that contains the topologies of all k input…

Discrete Mathematics · Computer Science 2014-03-03 Alexander Grigoriev , Steven Kelk , Nela Lekic

In this paper, we obtain the bounds of the extreme eigenvalues of a normalized and signless Laplacian matrices using by their traces. In addition, we determine the bounds for k-th eigenvalues of normalized and signless Laplacian matrices.

Combinatorics · Mathematics 2014-09-01 Şerife Büyükköse , Şehri Gülčiček Eski

There are several tools available to infer phylogenetic trees, which depict the evolutionary relationships among biological entities such as viral and bacterial strains in infectious outbreaks, or cancerous cells in tumor progression trees.…

Data Structures and Algorithms · Computer Science 2023-12-22 António Pedro Branco , Cátia Vaz , Alexandre P. Francisco

Exploratory data analysis is crucial for developing and understanding classification models from high-dimensional datasets. We explore the utility of a new unsupervised tree ensemble called uncharted forest for visualizing class…

Machine Learning · Statistics 2018-07-03 Casey Kneale , Steven D. Brown

There is a deep and interesting connection between the topological properties of a graph and the behaviour of the dynamical system defined on it. We analyse various kind of graphs, with different contrasting connectivity or degree…

Combinatorics · Mathematics 2017-05-01 Barbara Giunti , Vincenzo Perri

We propose a statistical method to test whether two phylogenetic trees with given alignments are significantly incongruent. Our method compares the two distributions of phylogenetic trees given by the input alignments, instead of comparing…

Populations and Evolution · Quantitative Biology 2010-04-14 Elissaveta Arnaoudova , David Haws , Peter Huggins , Jerzy W. Jaromczyk , Neil Moore , Chris Schardl , Ruriko Yoshida

Species tree estimation is a complex problem, due to the fact that different parts of the genome can have different evolutionary histories than the genome itself. One of the causes for this discord is incomplete lineage sorting (also called…

Populations and Evolution · Quantitative Biology 2019-04-09 Erin Molloy , Tandy Warnow

Evolutionary relationships between species are represented by phylogenetic trees, but these relationships are subject to uncertainty due to the random nature of evolution. A geometry for the space of phylogenetic trees is necessary in order…

Statistics Theory · Mathematics 2022-09-21 Jonas Lueg , Maryam K. Garba , Tom M. W. Nye , Stephan F. Huckemann

In this paper we investigate an extremal problem on binary phylogenetic trees. Given two such trees $T_1$ and $T_2$, both with leaf-set ${1,2,...,n}$, we are interested in the size of the largest subset $S \subseteq {1,2,...,n}$ of leaves…

Combinatorics · Mathematics 2013-02-21 Daniel M. Martin , Bhalchandra D. Thatte

In this paper, we give a linear algorithm for obtaining the Laplacian eigenvalues of a cograph. This approach is more efficient as there is no need to directly compute the eigenvalues of Laplacian matrix related to this class of graph. As…

Combinatorics · Mathematics 2024-09-16 Guantao Chen , Fernando C. Tura

Phylogenetic trees are leaf-labelled trees, where the leaves correspond to extant species (taxa), and the internal vertices represent ancestral species. The evolutionary history of a set of species can be explained by more than one…

Data Structures and Algorithms · Computer Science 2016-09-07 Asish Mukhopadhyay , Puspal Bhabak