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Mediation analyses play important roles in making causal inference in biomedical research to examine causal pathways that may be mediated by one or more intermediate variables (i.e., mediators). Although mediation frameworks have been well…

Applications · Statistics 2023-01-25 Meilin Jiang , Seonjoo Lee , James O'Malley , Yaakov Stern , Zhigang Li

Propensity score plays a central role in causal inference, but its use is not limited to causal comparisons. As a covariate balancing tool, propensity score can be used for controlled descriptive comparisons between groups whose memberships…

Methodology · Statistics 2022-09-09 Fan Li , Fan Li

The goal of causal mediation analysis, often described within the potential outcomes framework, is to decompose the effect of an exposure on an outcome of interest along different causal pathways. Using the assumption of sequential…

Methodology · Statistics 2021-11-09 Lexi Rene , Antonio R. Linero , Elizabeth Slate

As post hoc explanation methods are increasingly being leveraged to explain complex models in high-stakes settings, it becomes critical to ensure that the quality of the resulting explanations is consistently high across various population…

Machine Learning · Computer Science 2022-07-05 Jessica Dai , Sohini Upadhyay , Ulrich Aivodji , Stephen H. Bach , Himabindu Lakkaraju

Since the rise of fair machine learning as a critical field of inquiry, many different notions on how to quantify and measure discrimination have been proposed in the literature. Some of these notions, however, were shown to be mutually…

Computers and Society · Computer Science 2023-12-25 Drago Plecko , Elias Bareinboim

Health care decisions are increasingly informed by clinical decision support algorithms, but these algorithms may perpetuate or increase racial and ethnic disparities in access to and quality of health care. Further complicating the…

Methodology · Statistics 2024-02-28 Solvejg Wastvedt , Joshua Snoke , Denis Agniel , Julie Lai , Marc N. Elliott , Steven C. Martino

Recent evidence shows that deep learning models trained on electronic health records from millions of patients can deliver substantially more accurate predictions of risk compared to their statistical counterparts. While this provides an…

Decomposition analysis is a critical tool for understanding the social and spatial dimensions of segregation and diversity. In this paper, I highlight the conceptual, mathematical, and empirical distinctions between segregation and…

Methodology · Statistics 2024-02-22 Elizabeth Roberto

Mediation analysis is concerned with the decomposition of the total effect of an exposure on an outcome into the indirect effect through a given mediator, and the remaining direct effect. This is ideally done using longitudinal measurements…

Statistics Theory · Mathematics 2019-12-04 Murthy N Mittinty , Stijn Vansteelandt

The conventional model for assessing insensitivity to hidden bias in paired observational studies constructs a worst-case distribution for treatment assignments subject to bounds on the maximal bias to which any given pair is subjected. In…

Methodology · Statistics 2019-04-25 Colin B. Fogarty , Raiden B. Hasegawa

Matching is one of the most widely used causal inference designs in observational studies, but post-matching confounding bias remains a critical concern. This bias includes overt bias from inexact matching on measured confounders and hidden…

Methodology · Statistics 2026-02-26 Siyu Heng , Yanxin Shen , Pengyun Wang

Conducting disparity assessments at regular time intervals is critical for surfacing potential biases in decision-making and improving outcomes across demographic groups. Because disparity assessments fundamentally depend on the…

Computers and Society · Computer Science 2025-06-17 Jennah Gosciak , Aparna Balagopalan , Derek Ouyang , Allison Koenecke , Marzyeh Ghassemi , Daniel E. Ho

Clinical decisions to treat and diagnose patients are affected by implicit biases formed by racism, ableism, sexism, and other stereotypes. These biases reflect broader systemic discrimination in healthcare and risk marginalizing already…

Machine Learning · Computer Science 2025-01-29 Kara Liu , Russ Altman , Vasilis Syrgkanis

Overlap, also known as positivity, is a key condition for causal treatment effect estimation. Many popular estimators suffer from high variance and become brittle when features differ strongly across treatment groups. This is especially…

Machine Learning · Statistics 2026-04-02 Oscar Clivio , Alexander D'Amour , Alexander Franks , David Bruns-Smith , Chris Holmes , Avi Feller

Matching is one of the simplest approaches for estimating causal effects from observational data. Matching techniques compare the observed outcomes across pairs of individuals with similar covariate values but different treatment statuses…

Artificial Intelligence · Computer Science 2024-09-23 Abhishek Dalvi , Neil Ashtekar , Vasant Honavar

Managers, employers, policymakers, and others often seek to understand whether decisions are biased against certain groups. One popular analytic strategy is to estimate disparities after adjusting for observed covariates, typically with a…

Applications · Statistics 2024-01-29 Jongbin Jung , Sam Corbett-Davies , Johann D. Gaebler , Ravi Shroff , Sharad Goel

One of the fundamental challenges in drawing causal inferences from observational studies is that the assumption of no unmeasured confounding is not testable from observed data. Therefore, assessing sensitivity to this assumption's…

Methodology · Statistics 2024-06-25 Md Abdul Basit , Mahbub A. H. M. Latif , Abdus S Wahed

Identifying causal treatment (or exposure) effects in observational studies requires the data to satisfy the unconfoundedness assumption which is not testable using the observed data. With sensitivity analysis, one can determine how the…

Methodology · Statistics 2023-01-31 Yang Ou , Lu Tang , Chung-Chou H. Chang

Biological sequencing data consist of read counts, e.g. of specified taxa and often exhibit sparsity (zero-count inflation) and overdispersion (extra-Poisson variability). As most sequencing techniques provide an arbitrary total count,…

Applications · Statistics 2024-07-01 Noora Kartiosuo , Jaakko Nevalainen , Olli Raitakari , Katja Pahkala , Kari Auranen

Complex systems research is becomingly increasingly data-driven, particularly in the social and biological domains. Many of the systems from which sample data are collected feature structural heterogeneity at the mesoscopic scale (i.e.…

Physics and Society · Physics 2009-11-13 Jukka-Pekka Onnela , Neil F. Johnson , Sean Gourley , Gesine Reinert , Michael Spagat