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A two-stage adaptive optimal design is an attractive option for increasing the efficiency of clinical trials. In these designs, based on interim data, the locally optimal dose is chosen for further exploration, which induces dependencies…

Methodology · Statistics 2019-05-24 Zhantao Lin , Nancy Flournoy , William F. Rosenberger

The Multi-Reference Alignment (MRA) problem aims at the recovery of an unknown signal from repeated observations under the latent action of a group of cyclic isometries, in the presence of additive noise of high intensity $\sigma$. It is a…

Statistics Theory · Mathematics 2023-12-14 Subhro Ghosh , Soumendu Sundar Mukherjee , Jing Bin Pan

Stochastic resonance (SR), a phenomenon originally introduced in climate modeling, enhances signal detection by leveraging optimal noise levels within non-linear systems. Traditional SR techniques, mainly based on single-threshold…

Signal Processing · Electrical Eng. & Systems 2025-10-27 Dixon Vimalajeewa , Ursula U. Muller , Brani Vidakovic

As the maximum likelihood method is the most commonly used method for parameters estimation being unbiased, consistent, efficient, and asymptotically normal, MLE is used to fit the new distribution (MBUW). But in small to moderate sample…

Methodology · Statistics 2025-02-17 Iman Mohammed Attia

This paper describes how a priori information about the signal parameters can influence the accuracy of estimating the number of these signals. This study considers sinusoidal signals and it is supposed that the parameters (amplitudes,…

Signal Processing · Electrical Eng. & Systems 2020-09-03 Aleksandr Kharin , Oleg V. Chernoyarov

We study large deviation upper bounds and mean-squared error (MSE) guarantees of a general framework of nonlinear stochastic gradient methods in the online setting, in the presence of heavy-tailed noise. Unlike existing works that rely on…

Machine Learning · Computer Science 2025-03-25 Aleksandar Armacki , Shuhua Yu , Dragana Bajovic , Dusan Jakovetic , Soummya Kar

In this paper we describe a new methodology to calculate analytically the error for a maximum likelihood estimate (MLE) for physical parameters from Gravitational wave signals. All the existing litterature focuses on the usage of the Cramer…

General Relativity and Quantum Cosmology · Physics 2011-08-15 Michele Zanolin , Salvatore Vitale , Nicholas Makris

Several approximate inference algorithms have been proposed to minimize an alpha-divergence between an approximating distribution and a target distribution. Many of these algorithms introduce bias, the magnitude of which becomes problematic…

Machine Learning · Statistics 2021-10-27 Tomas Geffner , Justin Domke

State-space models (SSMs) are powerful probabilistic tools for modeling time-varying systems with latent dynamics. Inference in SSMs involves the estimation of latent states and parameters. In this work, we focus on parameter inference,…

Computation · Statistics 2026-05-22 Kostas Tsampourakis , Víctor Elvira

Neural likelihood estimation methods for simulation-based inference can suffer from performance degradation when the modeled data is very high-dimensional or lies along a lower-dimensional manifold, which is due to the inability of the…

Machine Learning · Statistics 2025-06-12 Simon Dirmeier , Carlo Albert , Fernando Perez-Cruz

We advocate for a practical Maximum Likelihood Estimation (MLE) approach towards designing loss functions for regression and forecasting, as an alternative to the typical approach of direct empirical risk minimization on a specific target…

Machine Learning · Statistics 2021-10-12 Pranjal Awasthi , Abhimanyu Das , Rajat Sen , Ananda Theertha Suresh

Mixed linear regression (MLR) model is among the most exemplary statistical tools for modeling non-linear distributions using a mixture of linear models. When the additive noise in MLR model is Gaussian, Expectation-Maximization (EM)…

Machine Learning · Statistics 2021-05-14 Babak Barazandeh , Ali Ghafelebashi , Meisam Razaviyayn , Ram Sriharsha

We propose a general approach to construct weighted likelihood estimating equations with the aim of obtaining robust parameter estimates. We modify the standard likelihood equations by incorporating a weight that reflects the statistical…

Statistics Theory · Mathematics 2025-07-24 Claudio Agostinelli , Ayanendranath Basu , Giulia Bertagnolli , Arun Kumar Kuchibhotla

We address the problem of signal denoising via transform-domain shrinkage based on a novel $\textit{risk}$ criterion called the minimum probability of error (MPE), which measures the probability that the estimated parameter lies outside an…

Applications · Statistics 2020-02-19 Jishnu Sadasivan , Subhadip Mukherjee , Chandra Sekhar Seelamantula

Objective evaluation of quantitative imaging (QI) methods using measurements directly obtained from patient images is highly desirable but hindered by the non-availability of gold standards. To address this issue, statistical techniques…

Methodology · Statistics 2020-06-04 Jinxin Liu , Ziping Liu , Joyce Mhlanga , Barry A. Siegel , Abhinav K. Jha

Much of the theory of estimation for exponential family models, which include exponential-family random graph models (ERGMs) as a special case, is well-established and maximum likelihood estimates in particular enjoy many desirable…

Computation · Statistics 2020-09-07 Christian S. Schmid , David R. Hunter

We consider the maximization of a submodular objective function $f:2^U\to\mathbb{R}_{\geq 0}$, where the objective $f$ is not accessed as a value oracle but instead subject to noisy queries. We introduce a versatile adaptive sampling…

Data Structures and Algorithms · Computer Science 2024-04-11 Wenjing Chen , Shuo Xing , Victoria G. Crawford

Weak lensing experiments are a powerful probe of cosmology through their measurement of the mass distribution of the universe. A challenge for this technique is to control systematic errors that occur when measuring the shapes of distant…

Cosmology and Nongalactic Astrophysics · Physics 2015-06-04 Alexandre Refregier , Tomasz Kacprzak , Adam Amara , Sarah Bridle , Barnaby Rowe

Estimating the clutter-plus-noise covariance matrix in high-dimensional STAP is challenging in the presence of Internal Clutter Motion (ICM) and a high noise floor. The problem becomes more difficult in low-sample regimes, where the Sample…

Signal Processing · Electrical Eng. & Systems 2025-05-13 Shashwat Jain , Vikram Krishnamurthy , Muralidhar Rangaswamy , Sandeep Gogineni , Bosung Kang , Sean M. O'Rourke

Lagrangian particle tracking is essential for characterizing turbulent flows, but inferring particle acceleration from inherently noisy position data remains a significant challenge. Fluid particles in turbulence experience extreme,…

Data Analysis, Statistics and Probability · Physics 2026-02-27 Griffin M Kearney , Kasey M Laurent , Makan Fardad
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