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Multiple Instance Learning (MIL) is increasingly being used as a support tool within clinical settings for pathological diagnosis decisions, achieving high performance and removing the annotation burden. However, existing approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Sungrae Hong , Kyungeun Kim , Juhyeon Kim , Sol Lee , Jisu Shin , Chanjae Song , Mun Yong Yi

Parkinson's disease is a neurological condition that occurs in nearly 1% of the world's population. The disease is manifested by a drop in dopamine production, symptoms are cognitive and behavioural and include a wide range of personality…

Image and Video Processing · Electrical Eng. & Systems 2024-01-08 Maria Frasca , Davide La Torre , Gabriella Pravettoni , Ilaria Cutica

Background:Speech patterns have emerged as potential diagnostic markers for conditions with varying etiologies. Machine learning (ML) presents an opportunity to harness these patterns for accurate disease diagnosis. Objective: This review…

Computation and Language · Computer Science 2025-03-10 Birger Moell , Fredrik Sand Aronsson , Per Östberg , Jonas Beskow

An extensive library of symptom inventories has been developed over time to measure clinical symptoms, but this variety has led to several long standing issues. Most notably, results drawn from different settings and studies are not…

Computation and Language · Computer Science 2023-09-12 Eamonn Kennedy , Shashank Vadlamani , Hannah M Lindsey , Kelly S Peterson , Kristen Dams OConnor , Kenton Murray , Ronak Agarwal , Houshang H Amiri , Raeda K Andersen , Talin Babikian , David A Baron , Erin D Bigler , Karen Caeyenberghs , Lisa Delano-Wood , Seth G Disner , Ekaterina Dobryakova , Blessen C Eapen , Rachel M Edelstein , Carrie Esopenko , Helen M Genova , Elbert Geuze , Naomi J Goodrich-Hunsaker , Jordan Grafman , Asta K Haberg , Cooper B Hodges , Kristen R Hoskinson , Elizabeth S Hovenden , Andrei Irimia , Neda Jahanshad , Ruchira M Jha , Finian Keleher , Kimbra Kenney , Inga K Koerte , Spencer W Liebel , Abigail Livny , Marianne Lovstad , Sarah L Martindale , Jeffrey E Max , Andrew R Mayer , Timothy B Meier , Deleene S Menefee , Abdalla Z Mohamed , Stefania Mondello , Martin M Monti , Rajendra A Morey , Virginia Newcombe , Mary R Newsome , Alexander Olsen , Nicholas J Pastorek , Mary Jo Pugh , Adeel Razi , Jacob E Resch , Jared A Rowland , Kelly Russell , Nicholas P Ryan , Randall S Scheibel , Adam T Schmidt , Gershon Spitz , Jaclyn A Stephens , Assaf Tal , Leah D Talbert , Maria Carmela Tartaglia , Brian A Taylor , Sophia I Thomopoulos , Maya Troyanskaya , Eve M Valera , Harm Jan van der Horn , John D Van Horn , Ragini Verma , Benjamin SC Wade , Willian SC Walker , Ashley L Ware , J Kent Werner , Keith Owen Yeates , Ross D Zafonte , Michael M Zeineh , Brandon Zielinski , Paul M Thompson , Frank G Hillary , David F Tate , Elisabeth A Wilde , Emily L Dennis

Clinical notes are a rich source of information about patient state. However, using them to predict clinical events with machine learning models is challenging. They are very high dimensional, sparse and have complex structure. Furthermore,…

Machine Learning · Statistics 2018-08-20 Sebastien Dubois , Nathanael Romano , David C. Kale , Nigam Shah , Kenneth Jung

Differentiating between the two main subtypes of Inflammatory Bowel Disease (IBD): Crohns disease (CD) and ulcerative colitis (UC) is a persistent clinical challenge due to overlapping presentations. This study introduces a novel…

Genomics · Quantitative Biology 2026-01-14 Myles Joshua Toledo Tan , Maria Kapetanaki , Panayiotis V. Benos

An imbalance between bodily heat production and heat dissipation leads to heat stress in organisms. In addition to diminished animal well-being, heat stress is detrimental to the poultry industry as poultry entails fast growth and high…

Biological Physics · Physics 2024-05-27 Prateek Verma , Elizabeth Adeogun , Elizabeth S. Greene , Sami Dridi , Ukash Nakarmi , Karthik Nayani

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

Quantitative Methods · Quantitative Biology 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

Network Intrusion Detection Systems (IDS) have become increasingly important as networks become more vulnerable to new and sophisticated attacks. Machine Learning (ML)-based IDS are increasingly seen as the most effective approach to handle…

Cryptography and Security · Computer Science 2025-02-14 Shrihari Vasudevan , Ishan Chokshi , Raaghul Ranganathan , Nachiappan Sundaram

The spinal cord (SC), which conveys information between the brain and the peripheral nervous system, plays a key role in various neurological disorders such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), in which both…

Image and Video Processing · Electrical Eng. & Systems 2021-10-14 Nilser J. Laines Medina , Charley Gros , Julien Cohen-Adad , Virginie Callot , Arnaud Le Troter

Sepsis is a dangerous condition that is a leading cause of patient mortality. Treating sepsis is highly challenging, because individual patients respond very differently to medical interventions and there is no universally agreed-upon…

Machine Learning · Computer Science 2018-11-28 Aniruddh Raghu , Matthieu Komorowski , Sumeetpal Singh

Syndrome differentiation in Traditional Chinese Medicine (TCM) is the process of understanding and reasoning body condition, which is the essential step and premise of effective treatments. However, due to its complexity and lack of…

Machine Learning · Computer Science 2019-01-23 Zeyuan Wang , Josiah Poon , Shiding Sun , Simon Poon

Parkinson's disease (PD) is a highly heterogeneous disease, including which motor symptoms are dominating. Imaging biomarkers that support subtype stratification could also improve biological understanding and study design, and enable…

Parkinsons disease (PD) is a debilitating motor system disorder characterized by progressive loss of movement, tremors, and speech slurring. PD is due to the loss of dopamine-producing brain cells, and symptoms only worsen over time, making…

Neurons and Cognition · Quantitative Biology 2014-05-07 Pooja Chandrashekar

Clinical notes are an essential component of a health record. This paper evaluates how natural language processing (NLP) can be used to identify the risk of acute care use (ACU) in oncology patients, once chemotherapy starts. Risk…

Computation and Language · Computer Science 2023-06-28 Claudio Fanconi , Marieke van Buchem , Tina Hernandez-Boussard

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

In psychiatric diagnosis, a contemporary data-driven, manual-based method for mental disorders classification is the most popular technique; however, it has several inevitable flaws. Using the three-way decision as a framework, we propose a…

Artificial Intelligence · Computer Science 2023-04-11 Huidong Wang , Md Sakib Ullah Sourav , Mengdi Yang , Jiaping Zhang

The functions and elasticities of the cell are largely related to the structures of the cytoskeletons underlying the lipid bi-layer. Among various cell types, the Red Blood Cell (RBC) possesses a relatively simple cytoskeletal structure.…

Biological Physics · Physics 2016-01-20 Lipeng Lai , Xiaofeng Xu , Chwee Teck Lim , Jianshu Cao

Background: Extensive clinical evidence suggests that a preventive screening of coronary heart disease (CHD) at an earlier stage can greatly reduce the mortality rate. We use 64 two-dimensional speckle tracking echocardiography (2D-STE)…

Machine Learning · Statistics 2021-05-21 Jingyi Zhang , Huolan Zhu , Yongkai Chen , Chenguang Yang , Huimin Cheng , Yi Li , Wenxuan Zhong , Fang Wang

Pain is an inherent part of human existence, manifesting as both physical and emotional experiences, and can be categorized as either acute or chronic. Over the years, extensive research has been conducted to understand the causes of pain…

Computation and Language · Computer Science 2025-07-14 Ancita Maria Andrade , Tanvi Banerjee , Ramakrishna Mundugar