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This study examines the application of Bayesian approach in the context of clinical trials, emphasizing their increasing importance in contemporary biomedical research. While conventional frequentist approach provides a foundational basis…

Methodology · Statistics 2026-01-16 Paramahansa Pramanik , Arnab Kumar Maity , Anjan Mandal , Haley Kate Robinson

For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints are widely chosen as the primary endpoint. Despite being commonly used, composite endpoints entail…

Methodology · Statistics 2022-09-27 Marta Bofill Roig , Guadalupe Gómez Melis , Martin Posch , Franz Koenig

The Brier score is a widely used metric evaluating overall performance of probabilistic predictions for binary outcomes in clinical research. However, its interpretation can be complex, as it does not align with commonly taught concepts in…

Applications · Statistics 2025-07-08 Linard Hoessly

Deploying deep learning models in real-world certified systems requires the ability to provide confidence estimates that accurately reflect their uncertainty. In this paper, we demonstrate the use of the conformal prediction framework to…

Machine Learning · Computer Science 2023-08-21 Léo Andéol , Thomas Fel , Florence De Grancey , Luca Mossina

Neural collaborative filtering is the state of art field in the recommender systems area; it provides some models that obtain accurate predictions and recommendations. These models are regression-based, and they just return rating…

Information Retrieval · Computer Science 2024-10-28 Jesús Bobadilla , Abraham Gutiérrez , Santiago Alonso , Ángel González-Prieto

Binary code similarity approaches compare two or more pieces of binary code to identify their similarities and differences. The ability to compare binary code enables many real-world applications on scenarios where source code may not be…

Cryptography and Security · Computer Science 2019-09-26 Irfan Ul Haq , Juan Caballero

This paper summarises the current state-of-the art in the study of compositionality in distributional semantics, and major challenges for this area. We single out generalised quantifiers and intensional semantics as areas on which to focus…

Computation and Language · Computer Science 2012-07-11 Daoud Clarke

Conformal inference has played a pivotal role in providing uncertainty quantification for black-box ML prediction algorithms with finite sample guarantees. Traditionally, conformal prediction inference requires a data-independent…

Methodology · Statistics 2023-07-04 Siddhaarth Sarkar , Arun Kumar Kuchibhotla

Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical and efficient. These benefits are achieved while preserving the integrity and validity of the…

Gibbs random fields play an important role in statistics, for example the autologistic model is commonly used to model the spatial distribution of binary variables defined on a lattice. However they are complicated to work with due to an…

Computation · Statistics 2012-07-25 Nial Friel

Cognitive diagnosis models have been popularly used in fields such as education, psychology, and social sciences. While parametric likelihood estimation is a prevailing method for fitting cognitive diagnosis models, nonparametric…

Statistics Theory · Mathematics 2025-10-01 Chengyu Cui , Yanlong Liu , Gongjun Xu

Bidirectional causal relationships arising from mutual interactions between variables are commonly observed within biomedical, econometrical, and social science contexts. When such relationships are further complicated by unobserved…

Methodology · Statistics 2026-01-27 Yafang Deng , Kang Shuai , Shanshan Luo

The awareness and mitigation of biases are of fundamental importance for the fair and transparent use of contextual language models, yet they crucially depend on the accurate detection of biases as a precursor. Consequently, numerous bias…

Computation and Language · Computer Science 2022-11-17 Silke Husse , Andreas Spitz

Causal discovery aims to learn causal relationships between variables from targeted data, making it a fundamental task in machine learning. However, causal discovery algorithms often rely on unverifiable causal assumptions, which are…

Machine Learning · Computer Science 2025-10-15 Huiyang Yi , Yanyan He , Duxin Chen , Mingyu Kang , He Wang , Wenwu Yu

We develop methods for forming prediction sets in an online setting where the data generating distribution is allowed to vary over time in an unknown fashion. Our framework builds on ideas from conformal inference to provide a general…

Methodology · Statistics 2021-12-10 Isaac Gibbs , Emmanuel Candès

Making binary decisions is a common data analytical task in scientific research and industrial applications. In data sciences, there are two related but distinct strategies: hypothesis testing and binary classification. In practice, how to…

Applications · Statistics 2021-12-01 Jingyi Jessica Li , Xin Tong

The minimization of specific cases in binary classification, such as false negatives or false positives, grows increasingly important as humans begin to implement more machine learning into current products. While there are a few methods to…

Machine Learning · Computer Science 2022-04-07 Sanskriti Singh

In this paper we study approaches for dealing with treatment when developing a clinical prediction model. Analogous to the estimand framework recently proposed by the European Medicines Agency for clinical trials, we propose a…

Probabilistic classifiers output a probability distribution on target classes rather than just a class prediction. Besides providing a clear separation of prediction and decision making, the main advantage of probabilistic models is their…

Machine Learning · Computer Science 2019-02-20 Juozas Vaicenavicius , David Widmann , Carl Andersson , Fredrik Lindsten , Jacob Roll , Thomas B. Schön

Algorithms are commonly used to predict outcomes under a particular decision or intervention, such as predicting whether an offender will succeed on parole if placed under minimal supervision. Generally, to learn such counterfactual…

Machine Learning · Statistics 2021-04-19 Amanda Coston , Edward H. Kennedy , Alexandra Chouldechova