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Systems with two species of active molecular motors moving on (cytoskeletal) filaments into opposite directions are studied theoretically using driven lattice gas models. The motors can unbind from and rebind to the filaments. Two motors…

Statistical Mechanics · Physics 2007-05-23 Stefan Klumpp , Reinhard Lipowsky

On the basis of the transport features and experimental phenomena observed in studies of molecular motors, we proposea double-temperature ratchet model of coupled motors to reveal the dynamical mechanism of cooperative transport of motors…

Classical Physics · Physics 2017-02-24 Chen-pu Li , Hong-bin Chen , Zhi-gang Zheng

We report transport properties and particle current rectification operation in a double-stranded tight-binding ladder network within non-equilibrium Green's function (NEGF) formalism that can easily be generalized in multi-stranded systems.…

Mesoscale and Nanoscale Physics · Physics 2019-09-05 Madhumita Saha , Santanu K. Maiti

The transport of molecules in confined media is subject to entropic barriers. So theoretically, asymmetry of the confinement length may lead to molecular ratchets with entropy as the only driving force for the biased transport. We address…

Soft Condensed Matter · Physics 2016-12-20 D. Lairez , M. -C. Clochard , J. -E. Wegrowe

The cystic fibrosis transmembrane conductance regulator (CFTR) is an important membrane protein in vertebrates. The function of CFTR is to transport chloride ions across the cell membrane, which is known to require adenosine triphosphate…

Several important biological processes are initiated by the binding of a protein to a specific site on the DNA. The strategy adopted by a protein, called transcription factor (TF), for searching its specific binding site on the DNA has been…

Biological Physics · Physics 2018-10-17 Soumendu Ghosh , Bhavya Mishra , Anatoly B. Kolomeisky , Debashish Chowdhury

Intramolecular symmetry-adapted perturbation theory (ISAPT) is a method to compute and decompose the noncovalent interaction energy between two molecular fragments A and B connected via a linker C. The existing ISAPT algorithm displays…

Chemical Physics · Physics 2022-09-13 Du Luu , Konrad Patkowski

Fluorescence molecular tomography (FMT) is an emerging powerful tool for biomedical research. There are two factors that influence FMT reconstruction most effectively. The first one is the regularization techniques. Traditional methods such…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Yan Liu , Wuwei Ren , Habib Ammari

Transport properties of asymmetric molecular structure are studied within the kinetic equation approach, taking into consideration the electron interaction in the self-consistent manner (SCF procedure). The device is made of a molecule…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 Kamil Walczak

Kinesins are processive motor proteins that move along microtubules in a stepwise manner, and their motion is powered by the hydrolysis of ATP. Recent experiments have investigated the coupling between the individual steps of single kinesin…

Soft Condensed Matter · Physics 2009-11-10 Anatoly B. Kolomeisky , Evgeny B. Stukalin , Alex A. Popov

Recent advances in computational power and simulation programs finally delivered the first examples of reversible folding for small proteins with an all-atom description. But having at hand the atomistic details of the process did not lead…

Biological Physics · Physics 2013-04-23 Ganna Berezovska , Diego Prada-Gracia , Francesco Rao

We model an overdamped Brownian particle that is subject to resetting facilitated by a ratchet potential on a spatially periodic domain. This asymmetric potential switches on with a constant rate, but switches off again only upon the…

Statistical Mechanics · Physics 2024-07-25 Connor Roberts , Emir Sezik , Eloise Lardet

We study the traffic of two types of molecular motors using the two-species symmetric simple exclusion process (ASEP) with periodic boundary conditions and with attachment and detachment of particles. We determine characteristic properties…

Biological Physics · Physics 2009-11-26 Yan Chai , Stefan Klumpp , Melanie J. I. Muller , Reinhard Lipowsky

Despite the broad use of fixed-point iterations throughout applied mathematics, the optimal convergence rate of general fixed-point problems with nonexpansive nonlinear operators has not been established. This work presents an acceleration…

Optimization and Control · Mathematics 2022-06-28 Jisun Park , Ernest K. Ryu

Achieving high-fidelity control in the presence of strong non-Markovian noise is critical for the optimization of emergent solid-state quantum devices. We present a highly efficient optimization framework that combines automatic…

Adenosine triphosphate (ATP) is a high-energy phosphate compound and the most direct energy source in organisms. ATP is an essential biomarker for evaluating cell viability in biology. Researchers often use ATP bioluminescence to measure…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Xuesheng Bian , Cheng Wang , Shuting Chen , Weiquan Liu , Sen Xu , Jinxin Zhu , Rugang Wang , Zexin Chen , Min Huang , Gang Li

In this paper we report, clarify and broaden various recent efforts to complement the chemistry-centered models of force generation in muscles by mechanics-centered models. The physical mechanisms of interest can be grouped into two…

Biological Physics · Physics 2018-06-26 Matthieu Caruel , Lev Truskinovsky

We aim to identify the control principles governing the adaptable formation of non-equilibrium structures in actomyosin networks. We build a phenomenological model and predict that biasing the energy dissipated by molecular motors should…

Cells control the size and organization of biomolecular condensates formed by liquid-liquid phase separation (LLPS), but multiple mechanisms likely contribute to this control and remain to be fully elucidated. Here we propose a…

Biological Physics · Physics 2026-04-10 Le Qiao , Peter Gispert , Lukas S. Stelzl , Friederike Schmid

In the classical context, it is well known that, sometimes, if the search does not find its target, it is better to start the process anew again, known as resetting. The quantum counterpart of resetting also indicates speeding up the…

Quantum Physics · Physics 2024-10-01 Pallabi Chatterjee , S. Aravinda , Ranjan Modak