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Traditionally, for most machine learning settings, gaining some degree of explainability that tries to give users more insights into how and why the network arrives at its predictions, restricts the underlying model and hinders performance…

Machine Learning · Computer Science 2021-04-06 Robin M. Schmidt

How perception and reasoning arise from neuronal network activity is poorly understood. This is reflected in the fundamental limitations of connectionist artificial intelligence, typified by deep neural networks trained via gradient-based…

Artificial Intelligence · Computer Science 2020-02-27 Paul J. Blazek , Milo M. Lin

Complex biological networks are fundamental to biomedical science, capturing interactions among molecules, cells, genes, and tissues. Deciphering these networks is critical for understanding health and disease, yet their scale and…

Machine Learning · Computer Science 2025-12-09 Sakib Mostafa , Lei Xing , Md. Tauhidul Islam

Deep learning methods for classifying medical images have demonstrated impressive accuracy in a wide range of tasks but often these models are hard to interpret, limiting their applicability in clinical practice. In this work we introduce a…

Image and Video Processing · Electrical Eng. & Systems 2019-08-13 James R. Clough , Ilkay Oksuz , Esther Puyol-Anton , Bram Ruijsink , Andrew P. King , Julia A. Schnabel

Deep neural networks (DNNs) transform stimuli across multiple processing stages to produce representations that can be used to solve complex tasks, such as object recognition in images. However, a full understanding of how they achieve this…

Neurons and Cognition · Quantitative Biology 2018-11-01 David G. T. Barrett , Ari S. Morcos , Jakob H. Macke

Clinical adoption of deep learning models has been hindered, in part, because the black-box nature of neural networks leads to concerns regarding their trustworthiness and reliability. These concerns are particularly relevant in the field…

Image and Video Processing · Electrical Eng. & Systems 2024-06-27 Lindsay Munroe , Mariana da Silva , Faezeh Heidari , Irina Grigorescu , Simon Dahan , Emma C. Robinson , Maria Deprez , Po-Wah So

Despite substantial progress in applying neural networks (NN) to a wide variety of areas, they still largely suffer from a lack of transparency and interpretability. While recent developments in explainable artificial intelligence attempt…

Computer Vision and Pattern Recognition · Computer Science 2021-05-04 Yunhao Ge , Yao Xiao , Zhi Xu , Meng Zheng , Srikrishna Karanam , Terrence Chen , Laurent Itti , Ziyan Wu

Medical imaging is a cornerstone of therapy and diagnosis in modern medicine. However, the choice of imaging modality for a particular theranostic task typically involves trade-offs between the feasibility of using a particular modality…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Mayur Mallya , Ghassan Hamarneh

Concept-based explanation methods, such as Concept Activation Vectors, are potent means to quantify how abstract or high-level characteristics of input data influence the predictions of complex deep neural networks. However, applying them…

Machine Learning · Computer Science 2023-10-18 Thomas Decker , Michael Lebacher , Volker Tresp

MRI-based modeling of brain networks has been widely used to understand functional and structural interactions and connections among brain regions, and factors that affect them, such as brain development and disease. Graph mining on brain…

Machine Learning · Computer Science 2022-05-18 Haoteng Tang , Xiyao Fu , Lei Guo , Yalin Wang , Scott Mackin , Olusola Ajilore , Alex Leow , Paul Thompson , Heng Huang , Liang Zhan

The design of interpretable deep learning models working in relational domains poses an open challenge: interpretable deep learning methods, such as Concept Bottleneck Models (CBMs), are not designed to solve relational problems, while…

Machine Learning · Computer Science 2024-10-28 Pietro Barbiero , Francesco Giannini , Gabriele Ciravegna , Michelangelo Diligenti , Giuseppe Marra

The layered structure of deep neural networks hinders the use of numerous analysis tools and thus the development of its interpretability. Inspired by the success of functional brain networks, we propose a novel framework for…

Machine Learning · Computer Science 2022-05-25 Ben Zhang , Zhetong Dong , Junsong Zhang , Hongwei Lin

Deep neural networks are commonly used for medical purposes such as image generation, segmentation, or classification. Besides this, they are often criticized as black boxes as their decision process is often not human interpretable.…

Machine Learning · Computer Science 2022-03-22 Jana Fragemann , Lynton Ardizzone , Jan Egger , Jens Kleesiek

Recent data-driven approaches to scene interpretation predominantly pose inference as an end-to-end black-box mapping, commonly performed by a Convolutional Neural Network (CNN). However, decades of work on perceptual organization in both…

Computer Vision and Pattern Recognition · Computer Science 2018-07-23 Chi Li , M. Zeeshan Zia , Quoc-Huy Tran , Xiang Yu , Gregory D. Hager , Manmohan Chandraker

We propose a novel perspective to understand deep neural networks in an interpretable disentanglement form. For each semantic class, we extract a class-specific functional subnetwork from the original full model, with compressed structure…

Machine Learning · Computer Science 2019-10-08 Yulong Wang , Xiaolin Hu , Hang Su

The representations learned by deep neural networks are difficult to interpret in part due to their large parameter space and the complexities introduced by their multi-layer structure. We introduce a method for computing persistent…

Machine Learning · Computer Science 2019-05-31 Thomas Gebhart , Paul Schrater , Alan Hylton

Deep neural networks (DNN) have achieved unprecedented performance in computer-vision tasks almost ubiquitously in business, technology, and science. While substantial efforts are made to engineer highly accurate architectures and provide…

Image and Video Processing · Electrical Eng. & Systems 2022-09-08 Sumedha Singla

Deep learning-based image processing is capable of creating highly appealing results. However, it is still widely considered as a "blackbox" transformation. In medical imaging, this lack of comprehensibility of the results is a sensitive…

Image and Video Processing · Electrical Eng. & Systems 2020-05-29 Bernhard Stimpel , Christopher Syben , Franziska Schirrmacher , Philipp Hoelter , Arnd Dörfler , Andreas Maier

To date, most discoveries of network subcomponents that implement human-interpretable computations in deep vision models have involved close study of single units and large amounts of human labor. We explore scalable methods for extracting…

Computer Vision and Pattern Recognition · Computer Science 2024-04-23 Achyuta Rajaram , Neil Chowdhury , Antonio Torralba , Jacob Andreas , Sarah Schwettmann

Surgical phase recognition plays a crucial role in surgical workflow analysis, enabling various applications such as surgical monitoring, skill assessment, and workflow optimization. Despite significant advancements in deep learning-based…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Ka Young Kim , Hyeon Bae Kim , Seong Tae Kim